Hemolysis detection device, system and method

Patent metadata

Field	Value
Publication number	US-10670614-B2
Application number	US-201916514304-A
Country	US
Kind code	B2
Filing date	Jul 17, 2019
Priority date	Sep 30, 2014
Publication date	Jun 2, 2020
Grant date	Jun 2, 2020

Abstract

Aspects of the present invention are directed to devices, systems and methods that enable the quick and reliable detection of hemolysis in a sample such that a sample which exhibits an unacceptable level of hemolysis can be flagged or disregarded in an associated diagnostic test.

First claim

The invention claimed is:

1. A device for determining an amount of hemoglobin in a plasma fraction wherein the device comprises:
a body with an upper portion and lower portion formed from a liquid impermeable material that is also inert to at least hemoglobin;
an opening defined in the upper portion of the body for introduction of a blood sample;
a plasma separation membrane disposed between the upper portion and the lower portion, the plasma separation membrane positioned to receive the blood sample from the opening;
a second membrane having a first portion positioned adjacent to and below the plasma separation membrane so as to receive a plasma fraction from the plasma separation membrane that was separated from the blood sample by the plasma separation membrane; and
a slit defined in the lower portion of the body and defining a pathway for energy to be applied to the second membrane, the slit overlapping a lower surface of the second membrane in a second portion of the second membrane that is not underneath the plasma separation membrane.

2. The device of claim 1 , wherein the plasma separation membrane comprises an asymmetric polysulfone material.

3. The device of claim 1 , wherein the second membrane is constructed of a porous or non-porous material that is inert to at least hemoglobin.

4. The device of claim 1 , wherein the second membrane is constructed of a cellulosic material, a glass fiber material, a porous polymeric material, or combinations thereof.

Assignees

• Siemens Healthcare Diagnostics Inc

Inventors

• Baxter Andrew John
• Cotton Paul William

Classifications

• G01N33/72

  involving blood pigments, e.g. haemoglobin, bilirubin {or other porphyrins; involving occult blood} · CPC title

• A61M1/34

  Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration · CPC title

• G01N33/483

  Physical analysis of biological material · CPC title

• G01N33/726

  Devices · CPC title

• Y10T436/255

  including use of a solid sorbent, semipermeable membrane, or liquid extraction · CPC title