System and method for performing a chromatography injection sequence using a single injection valve
US-2017336369-A1 · Nov 23, 2017 · US
Controllable injector sample dilution for a liquid chromatography system
US10670568B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10670568-B2 |
| Application number | US-201715782267-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 12, 2017 |
| Priority date | Sep 8, 2014 |
| Publication date | Jun 2, 2020 |
| Grant date | Jun 2, 2020 |
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Abstract
Official abstract text for this publication.
Described are a method and a system for injecting a sample into a flow of a liquid chromatography system. The method includes combining a flow of a sample and a flow of a mobile phase to create a diluted sample in the system flow. The volumetric flow rate of the sample is controlled to be at a value that yields a desired dilution ratio for the diluted sample. The particular value at which the volumetric flow rate is maintained can be determined from the desired value of the dilution ratio and the volumetric flow rate of the mobile phase. System embodiments include a syringe that can be used to provide a sample solution at a controllable volumetric flow rate for combination with a high pressure mobile phase.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for injecting a sample into a flow of a liquid chromatography system, the method comprising: providing a flow of a mobile phase at a first volumetric flow rate through a valve to a chromatographic column, the valve being operable in at least two states; and combining a flow of a sample at a second volumetric flow rate and the flow of the mobile phase in the valve, wherein the combined flows create a diluted sample in the valve that has a dilution ratio that is responsive to the first and second volumetric flow rates and wherein the second volumetric flow rate is controlled to a value so that the dilution ratio has a predetermined value. 2. The method of claim 1 wherein the sample includes a sample diluent. 3. The method of claim 2 wherein the dilution ratio is responsive to a dilution of the sample by the sample diluent and a dilution of the sample by the mobile phase. 4. The method of claim 2 wherein the sample diluent comprises a solvent that is capable of dissolving a greater quantity of the sample than the mobile phase. 5. The method of claim 1 wherein the mobile phase is a gradient mobile phase. 6. The method of claim 1 wherein the combining of the flow of the sample and the flow of the mobile phase occurs for a predetermined duration. 7. The method of claim 1 further comprising acquiring the sample from a sample source prior to combining the flow of the sample and the flow of the mobile phase. 8. A computer program product for injecting a sample into a flow of a liquid chromatography system, the computer program product comprising: a non-transitory computer readable storage medium having computer readable program code embodied therewith, the computer readable program code comprising: computer readable program code configured to provide a flow of a mobile phase at a first volumetric flow rate through a valve to a chromatographic column, the valve being operable in at least two states; and computer readable program code configured to combine a flow of a sample at a second volumetric flow rate and the flow of the mobile phase in the valve, wherein the combined flows create a diluted sample in the valve that has a dilution ratio that is responsive to the first and second volumetric flow rates and wherein the second volumetric flow rate is controlled to a value so that the dilution ratio has a predetermined value. 9. The computer program product of claim 8 wherein the computer readable program code further comprises computer readable program code configured to acquire the sample from a sample source prior to combining the flow of the sample and the flow of the mobile phase.
Assignees
Inventors
Classifications
- G01N30/20Primary
using a sampling valve · CPC title
rotary valves · CPC title
Preparation · CPC title
Liquid chromatography · CPC title
multiport valves, i.e. having more than two ports · CPC title
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Frequently asked questions
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- What does patent US10670568B2 cover?
- Described are a method and a system for injecting a sample into a flow of a liquid chromatography system. The method includes combining a flow of a sample and a flow of a mobile phase to create a diluted sample in the system flow. The volumetric flow rate of the sample is controlled to be at a value that yields a desired dilution ratio for the diluted sample. The particular value at which the v…
- Who is the assignee on this patent?
- Waters Technologies Corp
- What technology area does this patent fall under?
- Primary CPC classification G01N30/20. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).