4-((6-bromopyridin-3-yl)oxy)benzonitrile and processes of preparation

US10669237B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-10669237-B2
Application numberUS-201716462208-A
CountryUS
Kind codeB2
Filing dateNov 17, 2017
Priority dateNov 18, 2016
Publication dateJun 2, 2020
Grant dateJun 2, 2020

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

Provided herein is a process for the preparation of 4-((6-bromopyridin-3-yl)oxy)benzonitrile.

First claim

Opening claim text (preview).

What is claimed is: 1. A method of making a compound of Formula I comprising the step of contacting a compound of Formula II with a dehydrative brominating reagent. 2. The method of claim 1 , further comprising a solvent selected from the group including acetonitrile, toluene, DMF, DCM, and dioxane. 3. The method of claim 1 wherein the dehydrative brominating reagent may be selected from the group including POBr 3 , PBr 3 , PBr 5 , P 2 O 5 combined with tetrabutylammonium bromide, triphenylphosphine combined with N-bromosuccinimide, and mixtures thereof. 4. The method of claim 1 wherein the dehydrative brominating reagent may be selected from POBr 3 , PBr 5 , and mixtures thereof. 5. The method of claim 1 , wherein the contacting is carried out between about 50° C. and about 200° C. 6. The method of claim 1 , further comprising the step of: contacting a compound of Formula III with a compound of Formula IV and a base to prepare the compound of Formula II. 7. The method of claim 6 wherein the base is selected from the group including cesium carbonate, potassium carbonate, sodium hydride, potassium hydride, sodium hydroxide, and potassium hydroxide. 8. The method of claim 6 further comprising a solvent selected from the group including dimethylsulfoxide, N,N-dimethylacetamide, N,N-dimethylformamide, sulfolane, and N-methyl-2-pyrrolidone. 9. The method of claim 6 wherein the contacting is carried out between about 50° C. and about 200° C. 10. A compound consisting of:

Assignees

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Classifications

  • Two or more oxygen atoms · CPC title

  • C07D213/65Primary

    attached in position 3 or 5 · CPC title

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Frequently asked questions

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What does patent US10669237B2 cover?
Provided herein is a process for the preparation of 4-((6-bromopyridin-3-yl)oxy)benzonitrile.
Who is the assignee on this patent?
Dow Agrosciences Llc
What technology area does this patent fall under?
Primary CPC classification C07D213/65. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Jun 02 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).