Dialysis system

Patent metadata

Field	Value
Publication number	US-10668201-B2
Application number	US-201815865547-A
Country	US
Kind code	B2
Filing date	Jan 9, 2018
Priority date	Jun 7, 2010
Publication date	Jun 2, 2020
Grant date	Jun 2, 2020

Abstract

A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream.

First claim

We claim:

1. A dialysis system, comprising:
a water purification system comprising a microfluidic channel, flow field, or both, the water purification system capable of processing a household water stream in a non-batch process to produce a pasteurized water stream, the water purification system comprising a heat exchange system comprising
a fluid pathway having a water inlet and a water outlet, the fluid pathway further comprising
a first region where water flows in a first direction at a first temperature;
a heater region downstream of the first region, the water flowing into the heater region at the first temperature and the heater region comprising at least one heater that transfers heat into the water flowing through the heater region to increase the temperature to a second temperature greater than the first temperature; and
a second region downstream of the heater region where water flows in a second direction at a temperature greater than the first temperature, wherein water flowing in the second region thermally communicates with water flowing in the first region such that heat transfers from water flowing in the second region to water flowing in the first region resulting in a temperature reduction in the water as it flows through the second region, wherein water flows out of the fluid pathway through the water outlet at a temperature less than the second temperature;

a dialysate preparation system capable of mixing the pasteurized water stream with dialysate components to produce a dialysate stream; and
a dialyzer capable of being fluidly coupled to the dialysate stream and a blood stream.

2. The system of claim 1 , further comprising:
a plurality of pumps capable of pumping the dialysate stream through the dialyzer; and
a controller operatively coupled to the plurality of pumps, the controller capable of controlling a flow rate of the dialysate stream through one or more of the plurality of pumps so as to perform one or both of the processes of ultrafiltration and hemodiafiltration on the blood stream while the blood stream is undergoing dialysis.

3. The system of claim 1 , further comprising:
a flow balancer system that regulates dialysate flow to and from the dialyzer, the flow balance system comprising a first pump coupled to a fluid inlet pathway to the dialyzer and configured to pump dialysate through the fluid inlet pathway toward the dialyzer; and
a second pump coupled to a fluid outlet pathway from the dialyzer and configured to pump the fluid through the fluid outlet pathway away from the dialyzer.

4. The system of claim 3 , wherein the flow balancer system further comprises a third pump coupled to the fluid outlet pathway, the third pump configured to work in cooperation with the second pump to achieve a desired flow rate of fluid to or from the dialyzer.

5. The system of claim 4 , wherein the outlet pathway bifurcates into a main outlet pathway and a secondary outlet pathway, and wherein the second pump is coupled to the main outlet pathway and the third pump is coupled to the secondary outlet pathway.

6. The system of claim 1 , wherein the fluid pathway further comprises a dwell chamber downstream of the heater region and upstream of the second region, wherein the water is within the dwell chamber at or above the second temperature for at least a predetermined amount of time relative to a fluid flow rate through the dwell chamber, prior to flowing into the second region.

7. The system of claim 6 , wherein the first region, heater region, dwell chamber and second region are contained within a single laminar body.

8. The system of claim 6 , wherein the predetermined amount of time is based on a volume of the dwell chamber and the fluid flow rate.

9. The system of claim 1 , wherein the second temperature is at least 138° Celsius.

10. The system of claim 1 , further comprising a closed loop control arrangement for maintaining water in the fluid pathway above a saturation pressure such that the water does not change state at any point while present in the system.

Assignees

• Univ Oregon State
• Outset Medical Inc

Inventors

• Wrazel Julie S
• Curtis James R
• Nonn Ladislaus
• Peterson Richard B
• Wang Hailei
• Ingram-Goble Robbie
• Fisher Luke W
• Garrison Anna E
• Drost M Kevin
• Jovanovic Goran
• Miller Richard Todd
• Johnson Bruce W
• Anderson Alana
• Anderson Eric K

Classifications

• B01D2313/08

  Flow guidance means within the module or the apparatus · CPC title

• A61M1/1662

  with heat exchange between fresh and used dialysate · CPC title

• A61M1/1686 Primary

  by heat · CPC title

• F28D7/12

  the surrounding tube being closed at one end, e.g. return type (F28D7/14 takes precedence) · CPC title

• F28F3/08

  Elements constructed for building-up into stacks, e.g. capable of being taken apart for cleaning · CPC title