Coherent optical imaging for detecting neural signatures and medical imaging applications using common-path coherent optical techniques

Patent metadata

Field	Value
Publication number	US-10667692-B2
Application number	US-201615348604-A
Country	US
Kind code	B2
Filing date	Nov 10, 2016
Priority date	Nov 12, 2015
Publication date	Jun 2, 2020
Grant date	Jun 2, 2020

Abstract

Example apparatuses and methods relating to imaging systems are provided. An example imaging system may include an optical source configured to generate an optical beam, a beam splitter configured to split the optical beam into a reference beam and an object beam, and a beam combiner configured to route a combined beam with reference beam and object beam components along a common path into a target medium. In this regard, the target medium may act upon the combined beam to form a common path interference beam. The example imaging system may further include an imaging sensor configured to receive the common path interference beam and generate common path interference beam data associated with the common path interference beam, and an image data processor configured to analyze the common path interference beam data to generate image data describing the target medium.

First claim

That which is claimed:

1. An imaging system comprising:
an optical source configured to generate an optical beam;
a beam splitter configured to split the optical beam into a reference beam and an object beam, wherein the reference beam and the object beam are output from the beam splitter such that a reference beam polarization of the reference beam is different from an object beam polarization of the object beam;
a frequency shifter configured to shift a frequency of one of the reference beam or the object beam;
a beam combiner positioned to receive the reference beam and the object beam, combine the reference beam with the object beam to form a combined beam, and route the combined beam having a reference beam component and an object beam component directed along a common path into a target medium, the target medium acting upon the combined beam to form a common path interference beam;
a polarizer configured to polarize the combined beam or the common path interference beam;
an imaging sensor disposed downstream from the polarizer, the image sensor being configured to receive the common path interference beam and generate common path interference beam data associated with the common path interference beam; and
an image data processor configured to analyze the common path interference beam data to generate image data describing the target medium.

2. The imaging system of claim 1 wherein the polarizer is positioned to polarize the combined beam prior to interaction with the target medium.

3. The imaging system of claim 1 wherein the polarizer is positioned to polarize the common path interference beam after interaction with the target medium.

4. The imaging system of claim 3 wherein the image data processor is further configured to perform in-phase and quadrature demodulation on the common path interference beam data.

5. The imaging system of claim 1 wherein the image data processor is further configured to extract data for an amplitude modulated signal from the common path interference beam data using heterodyne detection.

6. The imaging system of claim 1 wherein the optical source comprises a short coherence length laser, and the optical source is configured to generate the optical beam in the form of a pulsed beam.

7. The imaging system of claim 1 further comprising a mount, wherein the optical source and the imaging sensor are affixed to the mount; and wherein the imaging sensor is configured to receive the common path interference beam after interaction with the target medium comprising neural tissue.

8. The imaging system of claim 1 further comprising an optical fiber operably connected to the optical source, wherein the optical fiber is configured to transmit the optical beam.

9. The imaging system of claim 1 further comprising a plurality of imaging sensors including the imaging sensor, wherein each imaging sensor generates respective common path interference beam data to be provided to the image data processor.

10. The imaging system of claim 1 wherein the image data processor is configured to analyze the common path interference beam data to generate image data describing the target medium in the form of a Fresnel zone pattern.

11. A method comprising:
generating an optical beam by an optical source;
splitting the optical beam by a beam splitter into a reference beam and an object beam, wherein the reference beam and the object beam are output from the beam splitter such that a reference beam polarization of the reference beam is different from an object beam polarization of the object beam;
frequency shifting one of the reference beam or the object beam;
combining the reference beam with the object beam to form a combined beam;
routing the combined beam along a common path into a target medium, the target medium acting upon the combined beam to form a common path interference beam;
polarizing, by a polarizer, the combined beam or the common path interference beam;
receiving the common path interference beam at an imaging sensor disposed downstream from the polarizer;
generating common path interference beam data associated with the common path interference beam; and
analyzing the common path interference beam data, by an image data processor, to generate image data describing the target medium, wherein analyzing the common path interference beam data includes coherently mixing the common path interference beam data for the object beam and the common path interference beam data for the reference beam.

12. The method of claim 11 further comprising polarizing the combined beam prior to entering the target medium.

13. The method of claim 11 further comprising polarizing the common path interference beam after interaction with the target medium.

14. The method of claim 13 wherein the analyzing further comprises performing in-phase and quadrature demodulation on the common path interference beam data.

15. The method of claim 11 further comprising extracting data for an amplitude modulated signal from the common path interference beam using heterodyne detection.

16. The method of claim 11 wherein generating the optical beam comprises generating the optical beam in the form of a pulsed beam by a short coherence length laser.

17. An apparatus comprising:
a mount comprising a transmit slot and a receiver slot;
an optical source configured to generate an optical beam;
a beam splitter configured to split the optical beam into a reference beam and an object beam, wherein the reference beam and the object beam are output from the beam splitter such that a reference beam polarization of the reference beam is different from an object beam polarization of the object beam;
a frequency shifter configured to shift a frequency of one of the reference beam or the object beam;
a beam combiner positioned to receive the reference beam and the object beam, combine the reference beam with the object beam to form a combined beam, and route the combined beam having a reference beam component and an object beam component directed along a common path via the transmit slot into a target medium, the target medium acting upon the combined beam to form a common path interference beam;
a polarizer configured to polarize the combined beam or the common path interference beam; and
an imaging sensor disposed downstream from the polarizer, the imaging sensor being configured to receive the common path interference beam via the receiver slot and generate common path interference beam data associated with the common path interference beam.

18. The apparatus of claim 17 , wherein the transmit slot extends in a transmit direction and the receiver slot extends in a receive direction, the transmit direction and the receive direction intersecting at a measurement depth point within the target medium and defining a first angle between the transmit direction and the receive direction.

19. The apparatus of claim 18 , further comprising a second imaging sensor;
wherein the mount further comprises a second receiver slot associated with the second imaging sensor;
wherein the second receiver slot extends in a second receive direction, the transmit direction and the second receive direction intersecting at a second measurement depth point within the target medium and defining a second angle between the transmit direction and the second receive direction; wherein the first angle is different from the second angle.

Assignees

• Univ Johns Hopkins

Inventors

• Blodgett David W
• Chevillet Mark A
• Hendrickson Scott M
• Mcloughlin Michael P

Classifications

• G02F2/00

  Demodulating light; Transferring the modulation of modulated light; Frequency-changing of light (G02F1/35 takes precedence) · CPC title

• A61B5/4064

  Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369) · CPC title

• G03H2001/0469

  Object light being reflected by the object · CPC title

• A61B5/0073

  by tomography, i.e. reconstruction of 3D images from 2D projections (A61B5/0066 takes precedence) · CPC title

• G01B9/02091

  Tomographic interferometers, e.g. based on optical coherence · CPC title