A series of pyrrole derivatives and their preparation method and therapeutic use
US-2024327423-A1 · Oct 3, 2024 · US
US10662201B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10662201-B2 |
| Application number | US-201816167590-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 23, 2018 |
| Priority date | Dec 15, 2017 |
| Publication date | May 26, 2020 |
| Grant date | May 26, 2020 |
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A compound of chemical formula I: or chemical formula II: or a pharmaceutical acceptable salt thereof is disclosed. R 1 , R 2 , R 3 , and R 4 are independently H, halogen, nitro, hydroxyl, cyano, benzyloxy, C 1 -C 8 straight or branched alkyl, C1-C8 straight or branched haloalkyl, C 1 -C 8 straight or branched alkoxy.
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What is claimed is: 1. A compound of chemical formula I or II: or a pharmaceutical acceptable salt thereof, wherein R 1 , R 2 , R 3 , and R 4 are independently H, halogen, nitro, hydroxyl, cyano, benzyloxy, C 1 -C 8 straight or branched alkyl, C 1 -C 8 straight or branched haloalkyl, C 1 -C 8 straight or branched alkoxy. 2. The compound of claim 1 , wherein R 1 is H, R 2 is F, R 3 is H, and R 4 is H. 3. The compound of claim 1 , wherein R 1 is H, R 2 is H, R 3 is F, and R 4 is H. 4. The compound of claim 1 , wherein R 1 is H, R 2 is H, R 3 is CF 3 , and R 4 is H. 5. The compound of claim 1 , wherein R 1 is H, R 2 is H, R 3 is CN, and R 4 is H. 6. The compound of claim 1 , wherein R 1 is F, R 2 is H, R 3 is CN, and R 4 is H. 7. The compound of claim 1 , wherein R 1 is H, R 2 is NO 2 , R 3 is F, and R 4 is H. 8. The compound of claim 1 , wherein R 1 is H, R 2 is CN, R 3 is H, and R 4 is F.
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