Thin molecules for the treatment of obesity and type II diabetes

Patent metadata

Field	Value
Publication number	US-10662153-B2
Application number	US-201716078254-A
Country	US
Kind code	B2
Filing date	Feb 27, 2017
Priority date	Feb 29, 2016
Publication date	May 26, 2020
Grant date	May 26, 2020

Abstract

Thin molecules, compounds producible by cleaving bilirubin at its methylene site in the center of the molecule, methods of making the same, and methods of using the same, are described.

First claim

What is claimed is:

1. A compound comprising Formula A or Formula B:

wherein R is selected from the group consisting of hydrogen and substituted or unsubstituted C 1 -C 6 alkyl; except when R is methyl;
and salts, stereoisomers, racemates, prodrugs, solvates, and hydrates thereof.

2. The compound of claim 1 , wherein R is one of ethyl, propyl, butyl, or pentyl.

3. The compound of claim 1 , comprising a mixture of Formula A and Formula B.

4. A pharmaceutical composition comprising:
an effective amount of a compound of claim 1 ; and
a pharmaceutically acceptable carrier, diluent, or adjuvant.

Assignees

• Univ Toledo

Inventors

• Hinds Jr Terry D
• Stec David E
• Trabbic Christopher J

Classifications

• A61P3/04

  Anorexiants; Antiobesity agents · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• C07D207/44 Primary

  having three double bonds between ring members or between ring members and non-ring members · CPC title