Injection device having variable dosing

Patent metadata

Field	Value
Publication number	US-10661014-B2
Application number	US-201615545358-A
Country	US
Kind code	B2
Filing date	Jan 21, 2016
Priority date	Jan 21, 2015
Publication date	May 26, 2020
Grant date	May 26, 2020

Abstract

An injection device for injecting medicament in a patient comprises a housing configured to house a fluid reservoir that has one of a plurality of volumes of medicament. An injection conduit fluidly coupled to the fluid reservoir defines a fluid pathway from the fluid reservoir to the patient. A firing mechanism is coupled to the fluid reservoir and is configured to expel the medicament from the fluid reservoir through the injection conduit. A volume setting mechanism is coupled to the firing mechanism and is configured to select the one of the plurality of volumes of medicament for the firing mechanism to expel. A dose setting mechanism is configured to select all or a fraction of the one of the plurality of volumes of medicament that is injected from the injection conduit when the firing mechanism is actuated.

First claim

We claim:

1. An injection device for injecting medicament in a patient comprising:
a housing configured to house a fluid reservoir having one of a plurality of volumes of medicament;
an injection conduit fluidly coupled to the fluid reservoir defining a fluid pathway from the fluid reservoir to the patient;
a firing mechanism coupled to the fluid reservoir and configured to expel the medicament from the fluid reservoir through the injection conduit;
a volume setting mechanism coupled to the firing mechanism and configured to be adjusted to select the one of the plurality of volumes of medicament for the firing mechanism to expel;
a dose setting mechanism configured to be adjusted to select a fraction of the one of the plurality of volumes of medicament that is injected from the injection conduit when the firing mechanism is actuated, and
wherein the volume setting mechanism includes a nut and the firing mechanism includes a ram and a biasing member, the nut being threadably coupled to the ram, the nut being releaseably retained against a force of the biasing member in an initial position by a latch.

2. The injection device of claim 1 , wherein the nut includes a plurality of indentations each configured to engage with a projection of the latch.

3. The injection device of claim 2 , wherein each of the plurality of indentations includes a ring shaped groove extending circumferentially around the nut.

4. The injection device of claim 1 further comprising a guard that is slideably coupled to the housing, wherein the guard is configured to release the latch from the nut.

5. The injection device of claim 4 further comprising a second biasing member coupled to the guard and configured to bias the guard toward a distal end of the injection device, the guard configured to extend axially past the injection conduit.

6. The injection device of claim 5 , wherein the guard extends further distally in a locked position than in an initial position.

7. The injection device of claim 1 , wherein the nut is rotatable relative to the latch.

8. The injection device of claim 1 , wherein the nut is configured to couple to the latch in one of a plurality of positions along an axial length of the nut, each of the plurality of positions along the axial length of the nut corresponding to one of the plurality of volumes of medicament for the firing mechanism to expel.

9. The injection device of claim 1 , wherein the volume setting mechanism includes a ram extension threadably coupled to the ram, the ram extension configured to extend the length of the ram to one of a plurality of positions corresponding to one of the plurality of volumes of medicament for the firing mechanism to expel.

10. The injection device of claim 1 , wherein the ram is rotatably fixed and axially moveable relative to the dose setting mechanism.

11. The injection device of claim 1 , wherein the latch includes a latch arm releaseably retaining the nut in the initial position and a stop engaging the nut in a fired position, a distance between the latch arm and the stop being fixed.

12. The injection device of claim 1 , wherein the firing mechanism includes a spring and the position of the spring being independent from the position of the dose setting mechanism.

13. The injection device of claim 1 , wherein the dose setting mechanism includes a knob rotatably coupled to the housing.

14. The injection device of claim 1 further comprising a guard slideably coupled to the housing and configured to extend axially past the injection conduit and lock relative to the housing after removing the injection conduit from the patient.

15. The injection device of claim 1 , wherein the injection conduit comprises a needle.

16. The injection device of claim 15 further comprising a syringe containing the fluid reservoir, wherein the needle is fixed to the syringe.

17. The injection device of claim 1 , wherein the injection device is configured to prevent resetting after the firing mechanism is actuated so as to prevent a subsequent injection of the medicament by the injection device, thereby configuring the injection device as a single-use injector.

18. The injection device of claim 1 , further comprising a safety cap coupled to the distal end of the housing, the safety cap being coupled to the firing mechanism such that decoupling the safety cap from the housing allows the firing mechanism to advance a predetermined distance relative to the fluid reservoir to prime the fluid reservoir.

19. The injection device of any of claim 1 , wherein the firing mechanism is configured to deliver each of the selected fraction of the one of the plurality of volumes of medicament over a generally equal amount of time as compared to one another.

20. The injection device of claim 1 , wherein the fraction is only greater than or equal to 0.5.

21. The injection device of any of claim 1 , wherein the selected fraction results in a residual volume remaining in the fluid reservoir after delivery of 0.18 ml or less.

22. An injection device for injecting medicament in a patient comprising:
a housing configured to house a fluid reservoir having one of a plurality of volumes of medicament;
an injection conduit fluidly coupled to the fluid reservoir defining a fluid pathway from the fluid reservoir to the patient;
a firing mechanism coupled to the fluid reservoir and configured to expel the medicament from the fluid reservoir through the injection conduit;
a volume setting mechanism coupled to the firing mechanism and configured to be adjusted to select the one of the plurality of volumes of medicament for the firing mechanism to expel;
a dose setting mechanism configured to be adjusted to select a fraction of the one of the plurality of volumes of medicament that is injected from the injection conduit when the firing mechanism is actuated, and
wherein actuating the dose setting mechanism advances the firing mechanism a predetermined distance relative to the fluid reservoir to prime the fluid reservoir.

23. The injection device of claim 22 , wherein the volume setting mechanism includes a nut and the firing mechanism includes a ram and a biasing member, the nut being threadably coupled to the ram, the nut being releaseably retained against a force of the biasing member in an initial position by a latch.

24. The injection device of claim 22 , wherein the nut includes a plurality of indentations each configured to engage with a projection of the latch.

25. The injection device of claim 24 , wherein each of the plurality of indentations includes a ring shaped groove extending circumferentially around the nut.

26. The injection device of claim 22 further comprising a guard that is slideably coupled to the housing, wherein the guard is configured to release the latch from the nut.

27. The injection device of claim 26 further comprising a second biasing member coupled to the guard and configured to bias the guard toward a distal end of the injection device, the guard configured to extend axially past the injection conduit.

28. The injection device of claim 27 , wherein the guard extends further distally in a locked position than in an initial position.

29. The injection device of claim 22 , wherein the nut is rotatable relative to the latch.

30. The injection device of claim 22 , wherein the nut is configured to cou

Assignees

• Antares Pharma Inc

Inventors

• Sarkinen Bryan James
• Travanty Michael
• Madsen Patrick
• Mork Andrew Charles

Classifications

• A61M2005/2013

  triggering of discharging means by contact of injector with patient body · CPC title

• A61M2005/2073

  preventing premature release, e.g. by making use of a safety lock · CPC title

• A61M5/31536

  Blocking means to immobilize a selected dose, e.g. to administer equal doses · CPC title

• A61M5/3204

  Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices · CPC title

• A61M5/2053

  Media being expelled from injector by pressurised fluid or vacuum (for infusion A61M5/145, A61M5/155) · CPC title