Pictet-spengler ligation for protein chemical modification
US-2015291699-A1 · Oct 15, 2015 · US
US10660966B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10660966-B2 |
| Application number | US-201515532938-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 4, 2015 |
| Priority date | Dec 4, 2014 |
| Publication date | May 26, 2020 |
| Grant date | May 26, 2020 |
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A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
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The invention claimed is: 1. A method for quantifying, removing or controlling acetaldehyde formation in a pharmaceutical formulation comprising the step of combining an aldehyde scavenger with a pharmaceutical formulation, wherein the pharmaceutical formulation comprises a radioactive pharmaceutical and a pharmaceutically acceptable solvent, wherein the aldehyde scavenger has the following structure: 2. The method according to claim 1 , wherein the radioactive pharmaceutical is a positron emission tomography (PET) tracer. 3. The method according to claim 1 , wherein the radioactive pharmaceutical is a 18 F PET tracer. 4. The method according to claim 1 , wherein the radioactive pharmaceutical is elected from the group of compounds comprising: 5. The method according to claim 1 , wherein the solvent comprises an alcohol. 6. The method according to claim 5 , wherein said alcohol is selected from ethanol, isopropanol or a bioalcohol. 7. The method according to claim 6 , wherein said alcohol is ethanol.
Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy (radiotherapy per se A61N5/10) · CPC title
the peptide being a RGD-containing peptide · CPC title
having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole · CPC title
Peptides, e.g. proteins {, carriers being peptides, polyamino acids, proteins} · CPC title
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein (oligopeptides having up to five amino acids {A61K47/183}; polyamino acids A61K47/34) · CPC title
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