Amphiphilic graft copolymers

Patent metadata

Field	Value
Publication number	US-10654979-B2
Application number	US-201816058366-A
Country	US
Kind code	B2
Filing date	Aug 8, 2018
Priority date	Aug 18, 2017
Publication date	May 19, 2020
Grant date	May 19, 2020

Abstract

Amphiphilic graft copolymers comprise a polypropylene backbone and polyoxyalkylene side-chains (PPMA-g-PEO-PPO). These copolymers are suitable as additives to base polymeric formulations for medical devices for improving bond strength, paintability, dyeability, and printablity.

First claim

What is claimed is:

1. A medical device formed from a blend comprising:
a base polymeric formulation comprising at least a polymer or co-polymer of propylene; and
an additive comprising a polypropylene-poly(ethylene oxide)-poly(propylene oxide) amphiphilic graft copolymer (PPMA-g-PEO-PPO);
the PPMA-g-PEO-PPO being present in the blend in an amount in the range of about 0.01 to about 5.0% by weight of the blend;
wherein the PPMA-g-PEO-PPO is according to Formula (I):

wherein Me is CH 3 ; the molar value of m is in the range from 5 to 25 mole percent; and
the molar value of n is in the range from 75 to 95 mole percent; the molar value of x is in the range from >0 to 40 propylene oxide units; and the molar value of y is in the range from >0 to 80 ethylene oxide units, and
wherein the medical device is in the form of tubing.

2. The medical device of claim 1 , wherein the base polymeric formulation comprises polypropylene, a polyethylene-polypropylene co-polymer, a polypropylene-containing thermoplastic elastomer (TPE), or combinations thereof.

3. The medical device of claim 1 , wherein the PPMA-g-PEO-PPO is a product of polymerization of a maleated polypropylene and a polymeramine having monoamine functionality.

4. The medical device of claim 1 , wherein the PPMA-g-PEO-PPO has a weight average molecular weight (Mw) in the range of about 5,000 to about 300,000 g/mol.

5. The medical device of claim 1 , wherein the PPMA-g-PEO-PPO has a molar ratio of EO:PO of 2:1 or greater.

6. The medical device of claim 1 , wherein the PPMA-g-PEO-PPO has a dispersity index in the range of 1.5 to 9.

Assignees

• Becton Dickinson Co

Inventors

• Hermel-Davidock Theresa
• Zhang Jianbin
• Datashvili Tea

Classifications

• A61L29/049

  Mixtures of macromolecular compounds · CPC title

• A61M39/10

  Tube connectors; Tube couplings {(A61M39/02 takes precedence; connecting needles to syringes or hubs A61M5/34; connecting catheter tubes to hubs A61M25/0014)} · CPC title

• A61M5/14

  Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor · CPC title

• A61M25/00

  Catheters; Hollow probes (dilators A61M29/00; {peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00} ; for measuring or testing A61B; {materials for catheters A61L29/00}) · CPC title

• C08L23/10

  Homopolymers or copolymers of propene · CPC title