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Production method for 1-amino cyclopropane carboxylic acid nonhydrate
US10654793B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10654793-B2 |
| Application number | US-201816611577-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 2, 2018 |
| Priority date | May 8, 2017 |
| Publication date | May 19, 2020 |
| Grant date | May 19, 2020 |
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- Title
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Abstract
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1-Aminocyclopropanecarboxylic acid non-hydrate can be obtained by treating 1-aminocyclopropanecarboxylic acid hydrochloride with a tertiary amine in the presence of a C 3 -C 4 alcohol and water, keeping the reaction mixture at 50° C. or below, collecting the precipitated crystal of 1-aminocyclopropanecarboxylic acid 0.5 hydrate by filtration, and heating the obtained crystal to 80 to 245° C.
First claim
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The invention claimed is: 1. A method of producing 1-aminocyclopropanecarboxylic acid non-hydrate, which comprises treating 1-aminocyclopropanecarboxylic acid hydrochloride with a tertiary amine in the presence of a C 3 -C 4 alcohol and water, keeping the reaction mixture at 50° C. or below, collecting the precipitated crystal of 1-aminocyclopropanecarboxylic acid 0.5 hydrate by filtration, and heating the obtained crystal to 80 to 245° C. 2. The method according to claim 1 , wherein the tertiary amine is triethylamine. 3. The method according to claim 1 , wherein the temperature for heating the crystal of 1-aminocyclopropanecarboxylic acid 0.5 hydrate is 80 to 150° C. 4. The method according to claim 1 , wherein the C 3 -C 4 alcohol is 2-propanol. 5. The method according to claim 1 , which further comprises a step of subjecting a C 1 -C 4 alkyl 1-acetylaminocyclopropanecarboxylate to hydrolysis using hydrochloric acid to obtain 1-aminocyclopropanecarboxylic acid hydrochloride.
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having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton · CPC title
with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring · CPC title
- C07C227/16Primary
by reactions not involving the amino or carboxyl groups · CPC title
Crystallisation · CPC title
Separation; Purification; Stabilisation; Use of additives (separation of optical isomers C07C227/34) · CPC title
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- What does patent US10654793B2 cover?
- 1-Aminocyclopropanecarboxylic acid non-hydrate can be obtained by treating 1-aminocyclopropanecarboxylic acid hydrochloride with a tertiary amine in the presence of a C 3 -C 4 alcohol and water, keeping the reaction mixture at 50° C. or below, collecting the precipitated crystal of 1-aminocyclopropanecarboxylic acid 0.5 hydrate by filtration, and heating the obtained cr…
- Who is the assignee on this patent?
- Sumitomo Chemical Co
- What technology area does this patent fall under?
- Primary CPC classification C07C227/16. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 19 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).