Cell processing system and method with centralized data management, monitoring and/or control

Patent metadata

Field	Value
Publication number	US-10654000-B2
Application number	US-201715456907-A
Country	US
Kind code	B2
Filing date	Mar 13, 2017
Priority date	Jul 13, 2016
Publication date	May 19, 2020
Grant date	May 19, 2020

Abstract

A network of cell processing systems including a plurality of cell processing instruments and a server computer. Each cell processing instrument includes a control circuit configured to operate the cell processing instrument according to a modifiable process parameter, a component of the cell processing instrument and a sensor configured to measure a characteristic of the component. The server computer is disposed remotely from the cell processing instruments, and is configured to transmit a request message for a value measured by the sensor, receive a response message based on the request message, and generate a notification message based on the response message.

First claim

The invention claimed is:

1. A system with centralized control, the system comprising:
at least one cell processing system, the cell processing system comprising:
a processor configured to receive a biological fluid to be processed,
the processor comprising a spinning separation device and a circuit including at least two containers in fluid communication with the spinning separation device, the at least two containers comprising a waste container and a product container; and
a controller coupled to the processor, the controller configured to operate the processor according to a process comprising at least one process parameter,
wherein the controller is configured to operate the processor to perform a priming step wherein fluid is passed through the circuit, at least one separation step wherein the spinning separation device produces at least two streams, one of the at least two streams being directed into the waste container, and at least one rinsing step wherein fluid is passed through the circuit after the at least one separation step, and
wherein the process includes the priming step, the at least one separation step, and the at least one rinsing step; and

a server in communication with the controller of the at least one cell processing system, the server configured to:
receive the process comprising at least one process parameter via an input;
calculate at least one in-process condition based on the at least one process parameter;
compare the at least one calculated in-process condition with at least one in-process condition control; and
transmit the process to the controller of the at least one cell processing system only if the at least one calculated in-process condition matches the at least one in-process condition control, the controller of the at least one cell processing system operating the processor according to the at least one process parameter of the process transmitted.

2. The system with centralized control according to claim 1 , wherein the server is configured to:
receive an identifier via an input coupled to the server;
determine if the identifier is associated with an administrator authorization; and
receive the process and transmit the process only if the identifier is associated with an administrator authorization.

3. The system with centralized control according to claim 1 , the spinning separation device comprising a spinning membrane separation device configured to separate the biological fluid into at least two streams according to the process.

4. The system with centralized control according to claim 1 , wherein the processor comprises the circuit and reusable hardware.

5. The system with centralized control according to claim 4 , wherein the circuit comprises a spinning membrane separation device that defines the spinning separation device, the at least two containers, and tubing connecting the spinning membrane and the at least two containers.

6. A system with centralized control, the system comprising:
at least one cell processing system, the cell processing system comprising:
a processor configured to receive a biological fluid to be processed,
the processor comprising a spinning separation device and a circuit including at least two containers in fluid communication with the spinning separation device, the at least two containers comprising a waste container and a product container; and
a controller coupled to the processor, the controller configured to operate the processor according to a process comprising at least one process parameter,
wherein the controller is configured to operate the processor to perform a priming step wherein fluid is passed through the circuit, at least one separation step wherein the spinning separation device produces at least two streams, one of the at least two streams being directed into the waste container, and at least one rinsing step wherein fluid is passed through the circuit after the at least one separation step, and
wherein the process includes the priming step, the at least one separation step, and the at least one rinsing step; and

a server in communication with the controller of the at least one cell processing system, the server configured to:
receive the process comprising at least one process parameter via an input;
calculate a plurality of in-process conditions corresponding to each step that defines the process;
compare a set of the plurality of calculated in-process conditions with a set of in-process condition controls; and
transmit the process to the controller of the at least one cell processing system only if the set of the plurality of calculated in-process conditions matches the set of in-process condition controls, the controller of the at least one cell processing system operating the processor according to the at least one process parameter of the process transmitted.

7. The system with centralized control according to claim 6 , the spinning separation device comprising a spinning membrane separation device configured to separate the biological fluid into at least two streams according to the process.

8. The system with centralized control according to claim 6 , wherein the processor comprises the circuit and reusable hardware.

9. The system with centralized control according to claim 8 , wherein the circuit comprises a spinning membrane separation device that defines the spinning separation device, the at least two containers, and tubing connecting the spinning membrane and the at least two containers.

Assignees

• Fenwal Inc

Inventors

• Binninger Steven C
• Olson Bret M
• Schlinker Alaina
• Wegener Christopher J

Classifications

• B01D63/16

  Rotary, reciprocated or vibrated modules · CPC title

• G16H40/67

  for remote operation · CPC title

• B01D2317/00

  Membrane module arrangements within a plant or an apparatus · CPC title

• C12M47/04

  Cell isolation or sorting (purging biological preparations of unwanted cells C12N5/0081, determining the presence or kind of microorganism C12Q1/04) · CPC title

• B01D61/22 Primary

  Controlling or regulating · CPC title