Binder powders

Patent metadata

Field	Value
Publication number	US-10653632-B2
Application number	US-201214001775-A
Country	US
Kind code	B2
Filing date	Feb 28, 2012
Priority date	Feb 28, 2011
Publication date	May 19, 2020
Grant date	May 19, 2020

Abstract

The present disclosure relates generally to binder powders for use in powder material processing and processes for their preparation. The disclosure further relates to binder powders for use in making solid powder compact forms, solid powder compact forms containing said binder powders and methods for making solid powder compact forms.

First claim

The invention claimed is:

1. A binder powder comprising:
spray-dried coated binder particles comprising core binder particles that are water soluble or wettable and a surface coating of L-leucine, isoleucine or trileucine covering a surface of each core binder particle, the L-leucine, isoleucine or trileucine provided in an effective amount of up to 20% by weight of the core binder particles to form a non-cohesive layer having an average layer thickness of about 1 μm or less on each of the core binder particles; and
wherein at least 80% by mass of the spray-dried coated binder particles have a volume equivalent spherical diameter of about 20 μm or less.

2. The binder powder according to claim 1 , wherein the core binder particles are selected from the group consisting of sugars, gelatine, dibasic calcium phosphate, corn (maize); starch, pregelatinized starch, acacia, xanthan gum, tragacanth, gelatine, alginic acid, polyethylene glycol, polyvinyl alcohols, polyvinylcaprolactam, polymethacrylates, polyvinylpyrrolidone (PVP), polyvinylpyrrolidone-vinyl acetate (PVP-V A), polyvinylcaprolactam-polyvinyl acetate-polyethylene glycol, methacrylic acid-ethylacrylate, polyvinylpyrrolidone and polyvinyl acetate, hydroxypropyl methylcellulose (HPMC), methyl cellulose, ethyl cellulose, hydroxyl propyl cellulose (HPC), hydroxyethylcellulose (HEC), and sodium carboxy methyl cellulose.

3. The binder powder according to claim 1 , wherein the core binder particles are a polymer, a co-polymer, or a mixture of polymers.

4. The binder powder according to claim 3 , wherein the core binder particles are polyvinylpyrrolidone (PVP).

5. The binder powder according to claim 1 , wherein the effective amount of the L-leucine, isoleucine or trileucine is about 2.5% to 15% by weight of the core binder particles.

6. The binder powder according to claim 1 wherein the volume equivalent spherical diameter of the coated binder particles is about 10 μm or less.

7. The binder powder according to claim 1 , wherein the volume equivalent spherical diameter of the coated binder particles is about 5 μm or less.

8. The binder powder according to claim 1 , wherein the non-cohesive layer of L-leucine, isoleucine or trileucine covers at least 40 percent of a total area of the surface of each core binder particle.

9. A binder powder comprising:
spray-dried binder particles including core binder particles that are water soluble or wettable and a non-cohesive surface coating agent of L-leucine, isoleucine or trileucine coated on a surface of each individual core binder particle, wherein the core binder particles are a polymer, a co-polymer, or a mixture of polymers;
the L-leucine, isoleucine or trileucine provided in an effective amount of about 2.5% to 15% by weight of the core binder particles to provide a non-cohesive surface layer having an average layer thickness of about 1 μm or less on each of the core binder particles; and
wherein at least 80% by mass of the spray-dried binder particles have a volume equivalent spherical diameter of about 20 μm or less.

10. The binder powder according to claim 9 , wherein the volume equivalent spherical diameter of the at least 80% by mass of the spray-dried binder particles is about 10 μm or less.

11. The binder powder according to claim 9 , wherein the core binder particles comprise polyvinylpyrrolidone (PVP).

12. The binder powder according to claim 9 , wherein at least one of the effective amount of the L-leucine, isoleucine or trileucine is about 7.5% to 10% by weight of the core binder particles, and the non-cohesive surface layer of L-leucine, isoleucine or trileucine covers on average at least 50% of the surface of each of the core binder particles.

13. The binder power according to claim 1 , wherein the spray-dried coated binder particles further comprise one or more active or functional ingredients.

14. The binder power according to claim 13 , wherein the one or more active or functional ingredients comprise an antimicrobial, analgesic, anti-depressant, anti-psychotic, anti-inflammatory, anti-arrhythmic, anti-coagulant, anti-cholesterol, anticonvulsant, anti-spasmodic, anti-arthritic, anti-ulcer agent, anti-hypertensive, anti-diabetic, diuretic, sedative or tranquilizer, amino acid, mineral, or vitamin.

15. A dry powder blend comprising a binder powder according to claim 1 together with at least one of a carrier and an active or functional ingredient.

16. A method of preparing coated binder particles, comprising:
spray-drying a liquid mixture of a binder that is water soluble or wettable and L-leucine, isoleucine or trileucine in an effective amount of up to 20% by weight of the binder to form fine spray-dried coated binder particles each with a binder core and a non-cohesive coating layer of L-leucine, isoleucine or trileucine having an average layer thickness about 1 μm or less on a surface of the binder core of the fine spray-dried coated binder particles;
wherein at least 80% by mass of the fine spray-dried coated binder particles have a volume equivalent spherical diameter of about 20 μm or less.

17. The method according to claim 16 , wherein the liquid mixture further includes one or more active or functional ingredients such that on spray-drying the fine spray-dried coated binder particles are formed with the binder core and the non-cohesive coating layer of L-leucine, isoleucine or trileucine together with the one or more active or functional ingredients.

18. The method according to claim 16 , wherein the binder is a polymer, a co-polymer, or a mixture of polymers.

19. The method according to claim 18 , wherein the binder is polyvinylpyrrolidone (PVP).

20. The method according to claim 16 , wherein the effective amount of the L-leucine, isoleucine or trileucine is about 2.5% to 15% by weight of the binder.

Assignees

• Morton David
• Orlando Laurence
• Zhou Tony Qi
• HO Louise Chia Hua
• Univ Monash

Inventors

• Morton David
• Orlando Laurence
• Zhou Tony Qi
• Ho Louise Chia-Hua

Classifications

• A61K31/405

  Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin · CPC title

• A61K9/2027

  obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates · CPC title

• A61K9/5089

  Processes · CPC title

• A61K9/5015 Primary

  Organic compounds, e.g. fats, sugars · CPC title

• A61K9/2013

  Organic compounds, e.g. phospholipids, fats · CPC title