Methods and kits of removing calculus

Patent metadata

Field	Value
Publication number	US-10653594-B2
Application number	US-201515535556-A
Country	US
Kind code	B2
Filing date	Dec 2, 2015
Priority date	Dec 15, 2014
Publication date	May 19, 2020
Grant date	May 19, 2020

Abstract

Methods and kits for removing calculus from a tooth. The method includes applying a component A comprising hydrogen peroxide or a precursor thereto to the tooth; applying a component B comprising a catalase to the tooth, thereby generating oxygen; and removing at least a part of the calculus from the tooth; wherein the component A is applied before or after the component B is applied.

First claim

What is claimed is:

1. A method of removing calculus from a tooth comprising:
applying a component A to the tooth surface, wherein the component A comprises at least 0.1 wt-% hydrogen peroxide or a precursor thereto providing at least 0.1 wt-% hydrogen peroxide;
applying a component B to the tooth surface, thereby generating oxygen, wherein the component B comprises at least 30 units/mL catalase; and
removing at least a part of the calculus from the tooth surface;
wherein the component A is applied to the tooth surface before or after the component B is applied to the tooth surface;
wherein after the component B is applied to the tooth surface, the concentration of catalase inside the oral cavity increases above the natural concentration of catalase present inside the oral cavity prior to the application of the component B.

2. The method of claim 1 , wherein the component A comprises at least 1 wt-% or a precursor thereto providing at least 1 wt-% hydrogen peroxide.

3. The method of claim 1 , wherein the component B comprises at least 300 units/mL catalase.

4. The method of claim 3 , wherein the component B comprises 300 units/mL to 300,000 units/mL catalase.

5. The method of claim 1 , wherein the component A is applied for a period less than about 1 hour.

6. The method of claim 1 , wherein the component B is applied for a period of less than about 1 hour.

7. The method of claim 1 , wherein the component A is applied to the tooth surface at least 30 seconds before or after the component B is applied to the tooth surface.

8. The method of claim 1 , wherein removing step occurs within 1 day after the applying steps.

9. The method of claim 1 , wherein the applying steps and removing step are all completed in less than about 1 day.

10. The method of claim 1 , wherein the hydrogen peroxide is a hydrogen peroxide adduct.

11. The method of claim 10 , wherein the hydrogen peroxide adduct is selected from the group consisting of carbamide peroxide, percarbonate salts or acids, polyvinylpyrrolidone (PVP) peroxide and combinations thereof.

12. The method of claim 1 , wherein the hydrogen peroxide precursor is selected from the group consisting of perborate salts or acids, metal peroxides, organic peroxide, inorganic peroxyacids or salts and combinations thereof.

13. The method of claim 12 , wherein the precursor is an organic peroxide, and wherein the organic peroxide is a peracetate salt or acid.

14. The method of claim 1 , wherein the hydrogen peroxide is generated by a peroxide generating enzyme.

15. The method of claim 1 , wherein the at least a part of the calculus is removed by mechanical means.

16. The method of claim 15 , wherein the at least a part of the calculus is removed by mechanical means other than toothbrushing.

17. The method of claim 16 , wherein the at least a part of the calculus is removed by a dental scaler.

18. The method of claim 1 , wherein the component A comprises at least 0.1 wt-% to 35 wt-% hydrogen peroxide or a precursor thereto providing 0.1 wt-% to 35 wt-% hydrogen peroxide.

19. The method of claim 2 , wherein the component A comprises 1 wt-% to 30 wt-% hydrogen peroxide or a precursor thereto providing 1 wt-% to 30 wt-% hydrogen peroxide.

20. The method of claim 19 , wherein the component A comprises 1 wt-% to 10 wt-% hydrogen peroxide or a precursor thereto providing 1 wt-% to 10 wt-% hydrogen peroxide.

21. The method of claim 1 , wherein the component B comprises 30 units/mL to 300,000 units/mL catalase.

22. The method of claim 4 , wherein the component B comprises 300 units/mL to 30,000 units/mL catalase.

23. A method of removing calculus from a tooth comprising:
applying a component A to the tooth surface, wherein the component A comprises 1 wt-% to 10 wt-% hydrogen peroxide or a precursor thereto providing 1 to 10 wt-% wt-% hydrogen peroxide;
applying a component B to the tooth surface, thereby generating oxygen, wherein the component B comprises at least 300 units/mL to 30,000 units/mL catalase; and
removing at least a part of the calculus from the tooth surface;
wherein the component A is applied to the tooth surface before or after the component B is applied to the tooth surface;
wherein after the component B is applied to the tooth surface, the concentration of catalase inside the oral cavity increases above the natural concentration of catalase present inside the oral cavity prior to the application of the component B.

Assignees

• 3M Innovative Properties Co

Inventors

• Haeberlein Ingo R
• Hajime Evan Koon Lun Yuuji
• Kohler Riedi Petra L
• Cao Chuntao
• Oxman Joel D
• Swanson Steven P
• Guggenberger Rainer A

Classifications

• A61K8/66

  Enzymes · CPC title

• A61K8/38

  Percompounds, e.g. peracids · CPC title

• A61K2800/884

  Sequential application · CPC title

• A61K8/8176

  Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers · CPC title

• A61K8/22 Primary

  Peroxides; Oxygen; Ozone · CPC title