Continuous sample delivery peristaltic pump

Patent metadata

Field	Value
Publication number	US-10648465-B2
Application number	US-201615345462-A
Country	US
Kind code	B2
Filing date	Nov 7, 2016
Priority date	Nov 7, 2016
Publication date	May 12, 2020
Grant date	May 12, 2020

Abstract

Methods and systems for pumping fluid through tubing are provided. Methods include orbiting one or more first rollers at multiple angular speeds around the periphery of a substantially circular first disk having a first radius with each first roller travelling at the same angular speed as the other first rollers, orbiting second rollers at a second angular speed around a substantially circular second disk having substantially the first radius, and increasing the pressure of fluid in tubing between one first roller and one second roller by causing the one or more first rollers to orbit at a first angular speed greater than the second angular speed so the one first roller moves along and fully compresses the tubing in a first section of the first disk, and simultaneously causing the one second roller to move along and fully compress the tubing in a first section of the second disk.

First claim

What is claimed is:

1. A method of pumping a fluid through a tubing that is positioned partially around a periphery of a first disk of a peristaltic pump and partially around a periphery of a second disk of the peristaltic pump, the method comprising:
orbiting one or more first rollers around the periphery of the first disk such that the one or more first rollers are pressed into contact with the periphery of the first disk, the tubing, or the periphery of the first disk and the tubing, wherein the first disk is substantially circular and has a first radius and wherein each first roller travels at the same angular speed as any other first roller at any given point in time;
orbiting a plurality of second rollers at a second angular speed around the entire periphery of the second disk such that the second rollers are pressed into contact with the periphery of the second disk, the tubing, or the periphery of the second disk and the tubing, wherein the second disk is substantially circular and has a second radius that is substantially the same as the first radius;
increasing a pressure of a portion of the fluid in the tubing between one first roller of the one or more first rollers and one second roller of the plurality of second rollers by causing the one or more first rollers to orbit at a first angular speed so that the one first roller moves along and fully compresses the tubing in a first section of the periphery of the first disk, and by simultaneously causing the one second roller to move along and fully compress the tubing in a first section of the periphery of the second disk, wherein the first angular speed is greater than the second angular speed; and
moving, after increasing the pressure of the portion of the fluid, the portion of the fluid through the tubing at a constant pressure towards an output of the tubing by causing the one or more first rollers to orbit at the second angular speed while the one first roller moves along and is fully compressing the tubing in a second section of the periphery of the first disk, and by simultaneously causing the one second roller to fully compress the tubing.

2. The method of claim 1 , further comprising reducing, after increasing the pressure of the portion of the fluid and before moving the portion of the fluid through the tubing at the constant pressure towards the output of the tubing, the angular speed of the one or more first rollers from the first angular speed to the second angular speed.

3. The method of claim 1 , further comprising reducing, after moving the portion of the fluid through a part of the tubing at the constant pressure towards the output of the tubing, the angular speed of the one or more first rollers to a third angular speed that is less than the second angular speed.

4. The method of claim 3 , wherein the third angular speed is zero.

5. The method of claim 3 , wherein the one or more first rollers move at the third angular speed while each of the first rollers is not fully compressing the tubing.

6. The method of claim 3 , wherein the one or more first rollers further comprise two or more first rollers, the method further comprising:
increasing, after reducing the angular speed of the two or more first rollers to the third angular speed, the pressure of another portion of the fluid in the tubing between another first roller of the two or more first rollers and another second roller of the plurality of second rollers by causing the two or more first rollers to orbit at the first angular speed while the another first roller moves along and fully compresses the tubing in the first section of the periphery of the first disk, and by simultaneously causing the another second roller to move along and fully compress the tubing in the first section of the periphery of the second disk, wherein the first angular speed is greater than the second angular speed.

7. The method of claim 6 , wherein:
the third angular speed is zero, and
the method further comprising orbiting, after stopping the movement of the two or more first rollers and before increasing the pressure of the another portion of the fluid in the tubing between the another first roller and the other second roller, the two or more first rollers at an angular speed less than or equal to the second angular speed.

8. The method of claim 3 , wherein:
the one or more first rollers comprise two or more first rollers,
the third angular speed is zero, and the method further comprising:
increasing, after stopping the movement of the two or more first rollers, the pressure of another portion of the fluid in the tubing between another first roller of the two or more first rollers and another second roller of the plurality of second rollers by causing the two or more first rollers to orbit at the first angular speed while the another first roller moves along and fully compresses the tubing in a third section of the periphery of the first disk, and by simultaneously causing the another second roller to move along and fully compress the tubing in a third section of the periphery of the second disk, wherein the first angular speed is greater than the second angular speed.

9. The method of claim 3 , wherein:
the one or more first rollers comprise two or more first rollers,
the third angular speed is zero, and
the method further comprising:
increasing, after stopping the movement of the two or more first rollers, the pressure of another portion of the fluid in the tubing between another first roller of the two or more first rollers and another second roller of the plurality of second rollers by causing the two or more first rollers to orbit at a fourth angular speed while the another first roller moves along and fully compresses the tubing in the first section of the periphery of the first disk, and by simultaneously causing the another second roller to move along and fully compress the tubing in the first section of the periphery of the second disk, wherein the fourth angular speed is greater than the second angular speed.

10. The method of claim 3 , wherein:
the one or more first rollers comprise two or more first rollers,
the third angular speed is zero, and
the method further comprising:
increasing, after stopping the movement of the two or more first rollers, the pressure of another portion of the fluid in the tubing between another first roller of the two or more first rollers and another second roller of the plurality of second rollers by causing the two or more first rollers to orbit at a fifth angular speed while the another first roller moves along and fully compresses the tubing in a fourth section of the periphery of the first disk, and by simultaneously causing the another second roller to move along and fully compress the tubing in a fourth section of the periphery of the second disk, wherein the fifth angular speed is different than the first angular speed and is greater than the second angular speed.

11. The method of claim 1 , wherein increasing the pressure of the portion of the fluid in the tubing between the one first roller and the one second roller accounts for air bubbles in the tubing between the one first roller and the one second roller by causing the one first roller to move to decrease the volume of the tubing between the one first roller and the one second roller.

12. The method of claim 11 , further comprising identifying intervals with a heightened probability of having the air bubbles in the tubing, wherein the identifying is based, at least in part, on data selected from the group consisting of: (a) data on the incremental movements of the one or more first rollers that move fluid from an uptake probe to the tubing while the uptak

Assignees

• Bio Rad Laboratories

Inventors

• Gaskill-Fox Nathan Michael
• Fox Daniel Nelson

Classifications

• F04B49/20 Primary

  by changing the driving speed · CPC title

• F04B23/06

  the pumps being all of reciprocating positive-displacement type · CPC title

• F04B2205/04

  Pressure in the outlet chamber · CPC title

• F04B51/00

  Testing machines, pumps, or pumping installations · CPC title

• F04B43/1261

  the rollers being placed at the outside of the tubular flexible member · CPC title