Heterocyclic compounds and uses thereof

Patent metadata

Field	Value
Publication number	US-10647716-B2
Application number	US-201916441610-A
Country	US
Kind code	B2
Filing date	Jun 14, 2019
Priority date	Sep 21, 2015
Publication date	May 12, 2020
Grant date	May 12, 2020

Abstract

Provided herein are heterocyclic compounds of Formula (I), pharmaceutical compositions containing such a compound and their therapeutic uses, methods for their preparation, intermediate compounds, pharmaceutical compositions containing such a compound, and their therapeutic uses.

First claim

What is claimed is:

1. A process of making compound 13:

said process comprising contacting compound 12:

with potassium tert-butoxide and iodomethane under conditions sufficient to form compound 13.

2. A process of making compound P-002:

said process comprising contacting compound 13:

with compound 13b:

in the presence of [1,1′-Bis(diphenyl-phosphino)ferrocene]dichloropalladium(II) under conditions sufficient to form compound P-002.

3. A process of making a compound P-001:

said process comprising contacting compound P-002:

with lithium hydroxide under conditions sufficient to form compound P-001.

4. A compound of formula:

5. A method for treating acute myeloid leukemia comprising administering to a subject in need thereof an effective amount of a compound of formula:

or a pharmaceutically acceptable salt thereof, and azacitidine.

6. A method for treating ovarian cancer comprising administering to a subject in need thereof an effective amount of a compound of formula:

or a pharmaceutically acceptable salt thereof, and carboplatin.

Assignees

• Plexxikon Inc

Inventors

• Ibrahim Prabha N
• Spevak Wayne
• Zhang Jiazhong
• Shi Songyuan
• Powell Ben
• Ma Yan

Classifications

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P13/02

  of urine or of the urinary tract, e.g. urine acidifiers · CPC title

• A61P21/04

  for myasthenia gravis · CPC title

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title