Ethynylbenzene derivatives
US-9738604-B2 · Aug 22, 2017 · US
Substituted hydroxamic acid compounds
US10647664B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10647664-B2 |
| Application number | US-201414912134-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 18, 2014 |
| Priority date | Aug 16, 2013 |
| Publication date | May 12, 2020 |
| Grant date | May 12, 2020 |
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Abstract
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Disclosed are compounds of formulae: (I), and (II) and pharmaceutically acceptable salts thereof, wherein the variables, R, R 1 , R 2 , R 3 , R 21 , R 22 , R 23 , R 34 , R 37 , R 33 , R 39 , D, Q, Y, X, X 1 , X 3 , and X 4 are defined herein. These compounds are useful for treating Gram-negative bacteria infections.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound that is: 4-((4-aminophenyl)buta-1,3-diynyl)-N-(3-hydroxy-1-(hydroxyamino)-2-methyl-1-oxobutan-2-yl)benzamide; or pharmaceutically acceptable salts thereof. 2. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier, solvent, adjuvant or diluent. 3. A method of treating Gram-negative bacterial infections, the method comprising administering to a subject in need of such treatment an effective amount of one or more compounds according to claim 1 . 4. A method of treating Gram-negative bacterial infections, the method comprising administering to a subject in need of such treatment an effective amount of one or more pharmaceutical composition according to claim 2 .
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Classifications
having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton · CPC title
- C07C259/06Primary
having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms · CPC title
attached in position 2 or 6 · CPC title
1,4-Oxazines, e.g. morpholine · CPC title
with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings · CPC title
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- What does patent US10647664B2 cover?
- Disclosed are compounds of formulae: (I), and (II) and pharmaceutically acceptable salts thereof, wherein the variables, R, R 1 , R 2 , R 3 , R 21 , R 22 , R 23 , R 34 , R 37 , R 33 , R 39 , D, Q, Y, X, X 1 , X 3 , and X 4 are defined herein. These compounds are useful for treating Gram-negative bacteria infections.
- Who is the assignee on this patent?
- Univ Duke, Univ Of North Carolina
- What technology area does this patent fall under?
- Primary CPC classification C07C259/06. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 12 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).