Contrast agent for photoacoustic imaging
US-2015290345-A1 · Oct 15, 2015 · US
Near-infrared dye-bound transferrin, and contrast agent for photoacoustic imaging, including the near-infrared dye-bound transferrin
US10646596B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10646596-B2 |
| Application number | US-201615070405-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 15, 2016 |
| Priority date | Mar 23, 2015 |
| Publication date | May 12, 2020 |
| Grant date | May 12, 2020 |
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Abstract
Official abstract text for this publication.
A novel near-infrared dye-bound transferrin exhibiting a high absorption coefficient in the near-infrared wavelength region, a high tumor accumulation property, a high tumor/blood ratio and a high imaging contrast, and a contrast agent for photoacoustic imaging, including the same are provided. A compound is provided in which transferrin and an organic dye having a specified structure that absorbs light in the near-infrared wavelength region are covalently bound.
First claim
Opening claim text (preview).
What is claimed is: 1. A contrast agent comprising a compound represented by formula (I-1): TF−(D)n (I-1), wherein, in the formula (I-1), TF represents transferrin, n is 4.8 to 7.0, and D represents formula (d5) or formula (d6): wherein, in the formulae (d5) and (d6), * represents a binding bond bound to the transferrin, and wherein, in the formula (d6), Y − represents a halogen ion or an organic acid ion. 2. A contrast agent comprising a compound represented by formula (I-1): TF−(D)n (I-1), wherein, in the formula (I-1), TF represents transferrin, D represents a near-infrared dye of formula (d5), and n is 4.8 to 7.0: wherein, in the formula (d5), * represents a binding bond bound to an amino group in the transferrin. 3. The contrast agent according to claim 1 , wherein the transferrin is any of human transferrin, a variant of human transferrin, a fragment of human transferrin, and a fragment of the variant of human transferrin. 4. The contrast agent according to claim 1 , further comprising a capturing molecule. 5. The contrast agent according to claim 1 , further comprising a dispersion medium, wherein the contrast agent is suitable for photoacoustic imaging. 6. The contrast agent according to claim 5 , further comprising an additive.
Assignees
Inventors
Classifications
Peptides, proteins, polyamino acids · CPC title
- A61K49/221Primary
characterised by the targeting agent or modifying agent linked to the acoustically-active agent · CPC title
Fluorescein, used in vivo · CPC title
- A61K49/0034Primary
Indocyanine green, i.e. ICG, cardiogreen · CPC title
Hybrid peptides {, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes} · CPC title
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- What does patent US10646596B2 cover?
- A novel near-infrared dye-bound transferrin exhibiting a high absorption coefficient in the near-infrared wavelength region, a high tumor accumulation property, a high tumor/blood ratio and a high imaging contrast, and a contrast agent for photoacoustic imaging, including the same are provided. A compound is provided in which transferrin and an organic dye having a specified structure that abso…
- Who is the assignee on this patent?
- Canon Kk
- What technology area does this patent fall under?
- Primary CPC classification A61K49/221. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 12 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 5 related publications on this page (citations in our corpus or others sharing the same primary CPC).