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Devices and methods using modified paper electrodes for the detection of hemoglobin A1C and glucose
US10640801B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10640801-B2 |
| Application number | US-201615276408-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 26, 2016 |
| Priority date | Sep 25, 2015 |
| Publication date | May 5, 2020 |
| Grant date | May 5, 2020 |
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Abstract
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Certain embodiments are directed to sensors that enable the use of optimized biocompatible materials such as pre-anodized paper printed electrode transducer to detect binding of a target agent, wherein the surface is modified or functionalized through zero length cross-linker so that it interacts with or specifically binds a target such as sugars (glucose) or glycated proteins (HgbA1c).
First claim
Opening claim text (preview).
The invention claimed is: 1. A glycated hemoglobin sensor comprising a conductive carbon ink printed electrode on a paper support having a functionalized surface coupled to a sugar reactive moiety, wherein the sugar reactive moiety binds glycated hemoglobin and is 3-AminoPhenyl-Boronic Acid (APBA) and wherein the conductive carbon contains surface carbonyl functionalities on edge plane sites. 2. A diagnostic device comprising the sensor of claim 1 . 3. A method of detecting glycated hemoglobin comprising (i) contacting a sensor of claim 1 with a sample to form an exposed sensor, and (ii) contacting the exposed sensor with a glycated hemoglobin detection reagent that produces a detectable signal in the presence of hemoglobin. 4. The method of claim 3 , wherein the detection reagent is H 2 O 2 . 5. The method of claim 3 , wherein the detectable signal is an electric signal. 6. The method of claim 5 , wherein the signal is generated by direct electron transfer. 7. The method of claim 3 , wherein the sample is blood or a blood fraction.
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Classifications
Functionalisation · CPC title
Glycosylated haemoglobin · CPC title
Boronic and borinic acid compounds · CPC title
Measurement method of reaction-produced change in sensor · CPC title
- C12Q1/006Primary
for glucose · CPC title
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- What does patent US10640801B2 cover?
- Certain embodiments are directed to sensors that enable the use of optimized biocompatible materials such as pre-anodized paper printed electrode transducer to detect binding of a target agent, wherein the surface is modified or functionalized through zero length cross-linker so that it interacts with or specifically binds a target such as sugars (glucose) or glycated proteins (HgbA1c).
- Who is the assignee on this patent?
- Li Xiujun, Henao Pabon Gilberto, Univ Texas
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/006. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 05 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).