Cationic Lipid Compound and Composition for Delivery of Nucleic Acids and Use Thereof
US-2024360072-A1 · Oct 31, 2024 · US
US10640452B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10640452-B2 |
| Application number | US-201916243237-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 9, 2019 |
| Priority date | Jan 12, 2018 |
| Publication date | May 5, 2020 |
| Grant date | May 5, 2020 |
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The surfactants which can be produced from the trialkylamine intermediates include the quaternary ammonium compounds of formula:
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We claim: 1. A quaternary ammonium compound of the formula: wherein R8 is methyl, ethyl, butyl, or benzyl, and X is a halide or alkosulfate, wherein R5 and R6 are independently selected from the group consisting of C 3 H 7 , C 2 H 5 , and CH 3 ; and wherein R7 is selected from the group consisting of C 3 H 7 , C 2 H 5 , CH 3 and H. 2. The quaternary ammonium compound of claim 1 wherein R6 is C2H5. 3. The quaternary ammonium compound of claim 1 wherein R5 and R6 independently are C2H5. 4. The quaternary ammonium compound of claim 1 wherein R5 is CH 3 . 5. The quaternary ammonium compound of claim 4 wherein R5 is CH3 and R6 is C2H5. 6. The quaternary ammonium compound of claim 1 wherein R8 is benzyl or butyl. 7. The quaternary ammonium compound of claim 6 wherein X— is halide. 8. The quaternary ammonium compound of claim 6 selected from N-benzyl-2,4-diethyl-N,N-dimethyloctan-1-aminium chloride or N-butyl-2,4-diethyl-N,N-dimethyloctan-1-aminium bromide. 9. A composition comprising the quaternary ammonium compound of claim 1 . 10. A composition comprising the quaternary ammonium compound of claim 9 wherein the composition does not contain combinations with other quaternary ammonium compounds. 11. The quaternary ammonium compound of claim 1 which is a disinfecting agent. 12. The quaternary ammonium compound of claim 11 having a minimum lethal concentration against at least one microbe selected from gram-positive bacteria, gram-negative bacteria, or yeast, when used at concentrations of less than 200 ppm. 13. The quaternary ammonium compound of claim 12 having a minimum lethal concentration against E. coli, S. aureus and C - albicans when used at concentrations of less than 200 ppm.
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