System, device and method for preparing tracers and transferring materials during radiosynthesis

Patent metadata

Field	Value
Publication number	US-10639608-B2
Application number	US-201213445147-A
Country	US
Kind code	B2
Filing date	Apr 12, 2012
Priority date	Apr 8, 2010
Publication date	May 5, 2020
Grant date	May 5, 2020

Abstract

A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container and the secondary container. The first line facilitates the flow of gas and/or liquid between the primary container and the secondary container. A valve located upstream of the secondary container and downstream of the primary container regulates flow within the first line; a second line in communication with the secondary container. For synthesizing a tracer, the system includes a source of a solution having a radionuclide. A first container has a tracer precursor and is in communication with the source of solution.

First claim

We claim:

1. A system for transferring chemical solutions, the system comprising:
a primary container;
a secondary container; where the primary container and the secondary container are reaction pots in which a reaction is conducted;
a third container in communication with the primary container, wherein the third container is disposed upstream of the primary container and configured to separate a radionuclide from the solution;
a first line in communication with the primary container and the secondary container, the first line configured to facilitate the flow of gas and/or liquid between the primary container and the secondary container;
a valve upstream of the secondary container and downstream of the primary container, the valve configured to regulate flow within the first line;
a second line in communication with the secondary container; and
a pressure source in communication with the primary container, the pressure source configured to drive gas and/or liquid to the secondary container via the first line; wherein the first line and the second line are configured to move within the secondary container; and wherein the first line and the second line are configured to move independently toward and away from a chemical solution when the chemical solution is in the secondary container; and
a radioactivity detector that is configured to measure radioactivity in the first container.

2. The system of claim 1 , wherein the secondary container is in communication with an HPLC load vial via the second line.

3. The system of claim 1 , wherein the system is configured to synthesize radiolabeled tracers.

4. A method of transferring chemical solutions, the method comprising:
providing a source of chemical reagents, reaction intermediates and/or products; where the chemical reagents, reaction intermediates and/or products are radioactive;
providing a container; where the container is a reaction pot in which a reaction is conducted; where the container is sealed;
providing a pressure source configured to move chemical reagents, reaction intermediates and/or products into the container;
providing a first line in communication with the source of chemical reagents, reaction intermediates and/or products and the container;
providing a second line in communication with the container, wherein the first line and the second line are configured to move relative to the container,
positioning the first line so that it interacts with chemical reagents, reaction intermediates and/or products when the chemical reagents, reaction intermediates, and/or products are introduced into the container;
positioning the second line so that it is excluded from interacting with the chemical reagents, reaction intermediates and/or products when the chemical reagents, reaction intermediates, and/or products are introduced into the container;
transferring the chemical reagents, reaction intermediates and/or products to the container through the first line, via pressure from the pressure source, such that the first line is in contact with the chemical reagents, reaction intermediates and/or products and the second line is out of contact with the chemical reagents, reaction intermediates and/or products;
moving the first line out of contact with the chemical reagents, reaction intermediates and/or products; and
moving the second line independent of the first line in contact with the chemical reagents, reaction intermediates or products; and where the first line and second line each contain needles that puncture the sealed container; and
detecting radioactivity via a radioactivity detector.

5. The method of claim 4 , further comprising closing the valve after the transferring step.

6. A system for synthesizing a tracer, the system comprising:
a source of a solution comprising a radionuclide;
a first container comprising a tracer precursor, the first container in communication with the source of solution comprising radionuclide;
a second container in communication with the first container, the second container configured to store the tracer; where the second container is sealed;
a first line in communication with the first container and the second container, the first line being configured to facilitate the flow of gas and/or liquid between the first container and the second container;
a second line in communication with the second container; wherein the first line and the second line are configured to move independently toward and away from a chemical solution when the chemical solution is in the secondary container; where the first line and second line each contain needles that puncture the sealed container;
a valve downstream of the source of solution comprising radionuclide and upstream of the first container; and
a radioactivity detector configured to measure radioactivity in the container.

7. The system of claim 6 , further comprising an apparatus configured to separate the radionuclide from the solution, wherein the apparatus is disposed downstream of the source of solution comprising a radionuclide and upstream of the first container.

8. The system of claim 7 , further comprising a third container in communication with the first container, wherein the third container is disposed upstream of the apparatus configured to separate the radionuclide from the solution.

9. The system of claim 8 , wherein the third container is configured to comprise an eluting solvent configured to elute radionuclide from the apparatus configured to separate the radionuclide from the solution.

10. The system of claim 6 , further comprising a gas source in communication with the third container, wherein the gas source is configured to push contents in the three containers toward the first container.

11. The system of claim 6 , further comprising an apparatus for transferring chemical solutions, the apparatus comprising: a first line in communication with the first container, the first line configured to deliver chemical reagents, reaction intermediates and/or reaction products to the first container; and a second line in communication with the first container, wherein the first line and second line are configured to move toward and away from the bottom of the first container.

12. The system of claim 6 , wherein at least one component is disposable.

13. A system for synthesizing a tracer, the system comprising:
a source of a solution comprising a radionuclide;
a first container comprising a tracer precursor, the first container in communication with the source of solution comprising radionuclide; where the first container is sealed;
an apparatus configured to separate the radionuclide from the solution, the apparatus being disposed downstream of the source of solution comprising radionuclide and upstream of the first container;
an apparatus for transferring chemical solution, the apparatus comprising: a first line in communication with the first container, the first line configured to deliver chemical reagents, reaction intermediates and/or reaction products to the first container; and a second line in communication with the first container, wherein the first line and second line are configured to independently move toward and away from the bottom of the first container; where the first line and second line each contain needles that puncture the sealed container;
a source of eluting solvent configured to elute radionuclide separated by the apparatus configured to separate the radionuclide from the solution; and
a radioactivity detector configured to measure radioactivity in the first container.

14. The system of claim 13 , wherein the first container comprises a trac

Assignees

• Gangadharmath Umesh B
• Walsh Joseph C
• Kolb Hartmuth C
• Rodriguez Ricardo
• Elizarov Arkadij M
• Ball Carroll Edward
• Siemens Medical Solutions Usa Inc

Inventors

• Gangadharmath Umesh B
• Walsh Joseph C
• Kolb Hartmuth C
• Rodriguez Ricardo
• Elizarov Arkadij M
• Ball Carroll Edward

Classifications

• C07B59/00

  Introduction of isotopes of elements into organic compounds {; Labelled organic compounds per se} · CPC title

• Y10T137/86035

  Combined with fluid receiver · CPC title

• B01J19/004 Primary

  Multifunctional apparatus for automatic manufacturing of various chemical products (sequential reactions B01J19/0046) · CPC title

• A61K51/08

  Peptides, e.g. proteins {, carriers being peptides, polyamino acids, proteins} · CPC title

• B01J4/008

  Feed or outlet control devices · CPC title