Coupling a body conduit to tissue

Patent metadata

Field	Value
Publication number	US-10639400-B2
Application number	US-201715840218-A
Country	US
Kind code	B2
Filing date	Dec 13, 2017
Priority date	Sep 15, 2014
Publication date	May 5, 2020
Grant date	May 5, 2020

Abstract

A method for coupling a body conduit to tissue includes engaging an implant about an outer surface of a catheter. The implant receives a bioactive agent having tissue growth properties. The method involves inserting the catheter through the body conduit and into a tissue opening across a resected area, positioning the implant in the resected area, inflating a balloon to anchor the catheter within the tissue opening such that the implant bridges the body conduit and the tissue opening across the resected area, and maintaining the catheter and the implant in vivo to enable the bioactive agent to secure the implant in the resected area to permanently bridge the body conduit and the tissue opening.

First claim

The invention claimed is:

1. A method for coupling a body conduit to tissue, the method comprising:
seeding a collagen-based scaffold with cells;
mounting the collagen-based scaffold on a catheter;
positioning the collagen-based scaffold within a body to provide a bridge between a conduit and a tissue opening each defined in the body; and
maintaining the catheter and the collagen-based scaffold in the body while the collagen-based scaffold forms a permanent connection with the conduit and the tissue opening,
wherein the collagen-based scaffold maintains the conduit and the tissue opening spaced from one another as the permanent connection is formed.

2. The method according to claim 1 , wherein the cells are human stem cells, the method further comprising changing a morphology of the human stem cells to render the collagen-based scaffold suitable for implantation within the body.

3. The method according to claim 2 , further comprising forming the collagen-based scaffold from a decellularized xenograft.

4. The method according to claim 3 , further comprising harvesting the xenograft from porcine tissue.

5. The method according to claim 4 , wherein the porcine tissue is a porcine urethra.

6. The method according to claim 2 , wherein changing the morphology of the human stem cells includes effecting a differentiation of the human stem cells.

7. The method according to claim 6 , wherein the differentiation of the human stem cells occurs ex vivo.

8. The method according to claim 1 , further comprising embedding the collagen-based scaffold with a bioactive agent having tissue growth properties, wherein the bioactive agent facilitates securing the collagen-based scaffold to the conduit and the tissue opening.

9. A method for coupling a body conduit to tissue, the method comprising:
positioning a collagen-based scaffold about a catheter;
inserting the catheter through a body conduit of a human body and into a tissue opening defined in the human body, thereby positioning the collagen-based scaffold in a resected area defined between the tissue opening and the body conduit, the tissue opening spaced from the body conduit to define the resected area;
maintaining the catheter and the collagen-based scaffold in the human body while the collagen-based scaffold forms a connection with the body conduit and the tissue opening, wherein the collagen-based scaffold maintains the body conduit and the tissue opening spaced from one another for a time sufficient to enable new tissue growth to form between the collagen-based scaffold and the body conduit and the collagen-based scaffold and the tissue opening; and
seeding the collagen-based scaffold with human stem cells.

10. The method according to claim 9 , further comprising changing a morphology of the human stem cells to render the collagen-based scaffold suitable for implantation within the human body.

11. The method according to claim 10 , further comprising forming the collagen-based scaffold from a decellularized xenograft.

12. The method according to claim 11 , further comprising harvesting the xenograft from porcine tissue.

13. The method according to claim 12 , wherein the porcine tissue is a porcine urethra.

14. The method according to claim 10 , wherein changing the morphology of the human stem cells includes effecting a differentiation of the human stem cells.

15. The method according to claim 14 , wherein the differentiation of the human stem cells occurs ex vivo.

16. The method according to claim 9 , further comprising embedding the collagen-based scaffold with a bioactive agent having tissue growth properties, wherein the bioactive agent facilitates securing the collagen-based scaffold to the body conduit and the tissue opening.

17. The method according to claim 9 , further comprising inflating a balloon of the catheter to anchor the catheter within the tissue opening such that the collagen-based scaffold bridges the body conduit and the tissue opening across the resected area.

Assignees

• Covidien Lp

Inventors

• Sartor Joe D
• Ross Anthony B
• Wohlert Stephen

Classifications

• A61L2300/414

  Growth factors · CPC title

• A61F2/958

  Inflatable balloons for placing stents or stent-grafts · CPC title

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61B2017/1135

  End-to-side connections, e.g. T- or Y-connections · CPC title

• A61B2017/00292

  mounted on or guided by flexible, e.g. catheter-like, means · CPC title