Use of electrochemical impedance spectroscopy (EIS) in intelligent diagnostics

Patent metadata

Field	Value
Publication number	US-10638947-B2
Application number	US-201414466177-A
Country	US
Kind code	B2
Filing date	Aug 22, 2014
Priority date	Dec 16, 2013
Publication date	May 5, 2020
Grant date	May 5, 2020

Abstract

Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

First claim

What is claimed is:

1. A method of differentiating between a first glucose sensor and a second glucose sensor, said first glucose sensor having a configuration that is different from said second glucose sensor, the method comprising:
performing a respective electrochemical impedance spectroscopy (EIS) procedure for each of said first and second glucose sensors;
generating, by a microprocessor, a respective Nyquist plot based on the output of each said respective EIS procedure;
based on said respective Nyquist plots, identifying, by said microprocessor, each of said first glucose sensor and said second glucose sensor;
based on said identification, selecting, by said microprocessor, a first one of a variety of initialization sequences to be applied to said first glucose sensor and a second one of said variety of initialization sequences to be applied to said second glucose sensor; and
applying said first one of said variety of initialization sequences to said first glucose sensor and applying said second one of said variety of initialization sequences to said second glucose sensor, wherein said identification is made based on the lower-frequency Nyquist slope length.

2. The method of claim 1 , wherein said length is calculated as the Cartesian distance between EIS at 0.105 Hz and 1 Hz.

Assignees

• Medtronic Minimed Inc

Inventors

• Varsavsky Andrea
• Miller Michael E
• Liang Bradley C

Classifications

• A61B5/1473

  invasive, e.g. introduced into the body by a catheter · CPC title

• A61M2005/1726

  the body parameters being measured at, or proximate to, the infusion site · CPC title

• A61B5/14865

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title

• A61M5/14244

  adapted to be carried by the patient, e.g. portable on the body · CPC title

• A61M5/14276

  specially adapted for implantation · CPC title