Drive mechanism for a drug delivery device

Patent metadata

Field	Value
Publication number	US-10632262-B2
Application number	US-201414782664-A
Country	US
Kind code	B2
Filing date	Apr 8, 2014
Priority date	Apr 10, 2013
Publication date	Apr 28, 2020
Grant date	Apr 28, 2020

Abstract

This disclosure relates to a drive mechanism for a drug delivery device and to a respective drug delivery device. The drive mechanism includes an elongated housing extending in an axial direction, an actuation member rotatably supported on the housing for setting of the dose. The drive mechanism further includes a last dose sleeve directly rotatably engaged with the actuation member and having at least one stop and a last dose member threadedly engaged with the last dose sleeve. The last dose member is further rotatably fixed to the housing and is operable to engage with the at least one stop to limit a rotation of the last dose sleeve.

First claim

The invention claimed is:

1. A drive mechanism for a drug delivery device for dispensing of a dose of a medicament, the drive mechanism comprising:
an elongate housing configured to extend along a longitudinal axis of the drug delivery device,
an actuation member rotatably supported on the housing for setting of the dose,
a last dose sleeve directly rotatably engaged with the actuation member and having a stop, the last dose sleeve further comprising a radially outwardly extending flange, and
a last dose member threadedly engaged with the last dose sleeve, the last dose member further being rotatably fixed to the housing and being operable to engage with the stop to limit rotation of the last dose sleeve relative to the last dose member,
wherein the last dose sleeve comprises an external thread mating with an internal thread of the last dose member, the internal thread of the last dose member at least partially surrounding a circumference of the last dose sleeve, and
wherein the stop extends radially outwardly at a distal end or a proximal end of the external thread of the last dose sleeve, and wherein the stop protrudes axially from an axial face of the flange, wherein the axial face faces towards and adjoins the external thread.

2. The drive mechanism of claim 1 , wherein:
the stop is a first stop,
the last dose sleeve comprises a second stop extending radially outwardly at a proximal end of the external thread, and
the last dose member is engageable with the first stop in a first circumferential direction and is engageable with the second stop in a second circumferential direction.

3. The drive mechanism according to claim 1 , wherein the last dose member comprises a radially outwardly extending protrusion engaged with an axially extending groove of the housing to limit rotation of the last dose member relative to the housing.

4. The drive mechanism according to claim 1 , wherein the last dose member is arc-shaped such that the last dose member engages a circumferential portion of the last dose sleeve, the last dose member comprising an edge to engage with the stop of the last dose sleeve in a circumferential direction.

5. The drive mechanism according to claim 1 , wherein the last dose sleeve and the last dose member are located in a receptacle at a proximal end of the housing.

6. The drive mechanism according to claim 5 , wherein the actuation member is rotatably supported on the proximal end of the housing.

7. The drive mechanism according to claim 5 , wherein the actuation member closes the receptacle of the housing.

8. The drive mechanism according to claim 1 , wherein the actuation member is displaceable along the longitudinal axis of the drug delivery device in a distal direction relative to the housing against a force of a spring element from a dose setting position to a dose dispensing position.

9. The drive mechanism according to claim 8 , wherein, when the actuation member is displaced into the dose dispensing position, the actuation member seals a proximal end of the housing.

10. The drive mechanism according to claim 8 , wherein the spring element is helically shaped and is configured to extend in a proximal direction along the longitudinal axis of the drug delivery device from a proximal end of the last dose sleeve, the spring element abuts against an inner proximal end face of the actuation member to bias the actuation member in the proximal direction.

11. The drive mechanism according to claim 1 , wherein the last dose sleeve comprises an axial recess to receive a correspondingly shaped distally extending journal of the actuation member such that the last dose sleeve and the actuation member are rotatably coupled.

12. The drive mechanism according to claim 1 , wherein the last dose sleeve comprises a radially extending flange portion at a distal end of the last dose sleeve to axially abut with a radially inwardly extending socket portion of the housing such that the last dose sleeve is radially confined in the housing.

13. The drive mechanism according to claim 1 , wherein the last dose sleeve is rotatably supported on a clutch at least partially extending into an interior of the last dose sleeve.

14. The drive mechanism according to claim 13 , wherein the last dose sleeve comprises a toothed surface at a distal end of a radially inwardly facing side wall of the last dose sleeve to selectively engage with correspondingly shaped radially outwardly extending teeth of the clutch.

15. The drive mechanism according to claim 13 , wherein the stop is a dose setting stop, and the clutch comprises a dose limiting stop being operable to engage with a corresponding stop on a dose limiting member to limit a rotation of the clutch relative to the dose limiting member.

16. The drive mechanism according to claim 1 , wherein a circumferential edge of the last dose member is operable to engage with the stop of the last dose sleeve.

17. The drive mechanism according to claim 1 , wherein the last dose member comprises a leading edge and a trailing edge in a circumferential direction with respect to a sense of rotation of the last dose sleeve relative to the last dose member, and wherein at least one of the leading edge or the trailing edge of the last dose member is configured to abut in the circumferential direction with the stop when the last dose member reaches a last dose limiting configuration.

18. A drug delivery device for dispensing of a dose of a medicament, the drug delivery device comprising:
a drive mechanism comprising
an elongate housing extending in an axial direction,
an actuation member rotatably supported on the housing for setting of the dose,
a last dose sleeve directly rotatably engaged with the actuation member and having a stop, the last dose sleeve further comprising a radially outwardly extending flange, and
a last dose member threadedly engaged with the last dose sleeve, further being rotatably fixed to the housing and being operable to engage with the stop to limit a rotation of the last dose sleeve relative to the last dose member,
wherein the last dose sleeve comprises an external thread mating with an internal thread of the last dose member, the internal thread of the last dose member at least partially surrounding a circumference of the last dose sleeve, and
wherein the stop extends radially outwardly at a distal end or a proximal end of the external thread of the last dose sleeve, and wherein the stop protrudes axially from an axial face of the flange, wherein the axial face faces towards and adjoins the external thread; and

a cartridge at least partially filled with the medicament and being engaged to the drive mechanism, the cartridge being arranged in the housing or being arranged in a cartridge holder fixed to the housing.

19. A method of dispensing a dose of a medicament using an injection device comprising an actuation member, the method comprising:
rotating the actuation member to rotate a last dose sleeve of the last dose mechanism relative to a last dose member of the last dose mechanism to set a dose, an external thread of the last dose sleeve mating with an internal thread of the last dose member at least partially surrounding a circumference of the last dose sleeve, the actuation member being directly rotatably engaged with the last dose mechanism such that a stop of the last dose sleeve of the last dose mechanism limits a rotation of the actuation member, the stop extending radially outwardly at a distal end or a proximal end of an external thread of the last dose sleeve, the stop pr

Assignees

• Sanofi Sa

Inventors

• Bayer Stefan
• Berning Daniel
• Blank Philippe
• Pelzer Wolfgang
• Pfoser Michael
• Wilden Björn

Classifications

• A61M5/31511

  Piston or piston-rod constructions, e.g. connection of piston with piston-rod (A61M5/5066 takes precedence) · CPC title

• A61M5/31583

  based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod · CPC title

• A61M5/31541

  Means preventing setting of a dose beyond the amount remaining in the cartridge · CPC title

• A61M5/31553

  without axial movement of dose setting member · CPC title

• A61M2205/582

  by tactile feedback · CPC title