Method of making injectable cements

Patent metadata

Field	Value
Publication number	US-10632227-B2
Application number	US-201615548389-A
Country	US
Kind code	B2
Filing date	Feb 8, 2016
Priority date	Feb 9, 2015
Publication date	Apr 28, 2020
Grant date	Apr 28, 2020

Abstract

A discovery of the conversion of amorphous calcium polyphosphate (ACPP) or/and other polyphosphate salts with various type of calcium phosphate to new calcium phosphate product (i.e. dicalcium phosphate dihydrate (DCPD)) in a liquid environment. The discovery includes mixing a various type of calcium phosphate with an aqueous ACPP or/and other polyphosphate salts gel, which is fast setting and possessing strong mechanical strength, and can be gradually converted to DCPD/hydroxyapatites in physiological condition. This injectable past can be applied as alternative of conventional CPC bone cement that is suitable for bone void repair due to its excellent properties in osteoconductivity and osseointegration. It can also be applied as drug delivery device in tissue engineering for its strong bonding to drug molecules.

First claim

The invention claimed is:

1. A cement comprising:
a hydrogel including a polyphosphate selected from the group consisting of sodium polyphosphate, potassium polyphosphate, calcium polyphosphate, strontium polyphosphate, magnesium polyphosphate, aluminum polyphosphate, zinc polyphosphate, copper polyphosphate, cadmium polyphosphate, manganese polyphosphate, and ammonium polyphosphate, and
tetracalcium phosphate,
wherein a ratio of the hydrogel to tetracalcium phosphate is 1:0.1 to 1:10 by weight,
wherein the cement is injectable and has a mechanical strength for a bone repair application.

2. The cement of claim 1 , wherein the cement has a setting mechanism comprising reaction of dehydration of the hydrogel.

3. The cement of claim 1 wherein the polyphosphate has a degree of polymerization of at least about 2.

4. The cement of claim 1 wherein the mechanical strength comprises a compressive strength of between about 5 megapascal and about 200 megapascal.

5. The cement of claim 1 further comprising at least one of an inorganic filler and an organic filler.

6. The cement of claim 5 wherein the inorganic filler comprises at least one of a bioglass, a silica ceramic, an oxide ceramic, a carbon fiber, a metal, and a metal alloy.

7. The cement of claim 5 wherein the inorganic filler comprises a powder having a particle size of about 1 nanometer to about 1000 micrometers.

8. The cement of claim 5 comprising at least one of a polycarboxylate, a polysulfate, polysulfonates, a polyphosphate, a polyamine, a polyurea, a polyamide, a polyalkylene oxide diol, a polyalkylene oxide diamine, a polycarbonate, a polylactone, a polyethersulfone, a polyvinyl, a polypeptide, a polysaccharide, a polyurethane, a polysulfone, a polyester, polyethylene, polypropylene, polystyrene, polysilicone, poly(acrylonitrile-butadienestyrene), polybutadiene, polyisoprene, polymethylmethacrylate, polyvinylacetate, polyacrylonitrile, polyvinyl chloride, polyethylene terephtalate, cellulose, a polysilicone, a polyolefin, a polyvinyl derivative, a polypeptide derivative, poly(lactic-co-glycolic acid), and a polysaccharide derivative.

9. The cement of claim 5 , comprising at least one of a carboxylate, a sulfate, a sulfonate, a phosphate, an amine, urea, an amide, an alkylene oxide diol, an alkylene oxide diamine, a carbonate, a lactone, an ethersulfone, a vinyl, a peptide, a dimethacrylate, a saccharide, a urethane, a sulfone, an ester, an ethylene, propylene, a styrene, silicone, acrylonitrile-butadienestyrene, butadiene, an isoprene, methylmethacrylate, vinylacetate, acrylonitrile, vinyl chloride, ethylene terephtalate, an olefin, a vinyl derivative, bisphenol A, a bisphenol A derivative, an oligosaccharide, a peptide derivative, lactic acid, glycolic acid, cyanoacrylate, a cyanoacrylate derivative, and a saccharide derivative.

10. The cement of claim 1 having a setting time from 1 minute to about 30 minutes.

11. The cement of claim 1 having a ratio of calcium to phosphate of about 1:10 to about 10:1.

12. The cement of claim 1 , wherein the polyphosphate is an amorphous polyphosphate.

13. The cement of claim 12 , comprising amorphous calcium polyphosphate.

14. The cement of claim 1 , wherein the ratio is 1:0.15 to 1:1.

15. A method of making an injectable bone cement, the method comprising:
gelating a polyphosphate compound in aqueous solution to form a hydrogel, the polyphosphate compound being selected from the group consisting of sodium polyphosphate, potassium polyphosphate, calcium polyphosphate, strontium polyphosphate, magnesium polyphosphate, aluminum polyphosphate, zinc polyphosphate, copper polyphosphate, cadmium polyphosphate, manganese polyphosphate, ammonium polyphosphate; and
reacting the hydrogel with tetracalcium phosphate wherein the ratio of the hydrogel to tetracalcium phosphate is 1:0.1 to 1:10 by weight, to form the injectable bone cement.

16. The method of claim 15 further comprising mixing a filler material with the polyphosphate compound, the filler material comprising at least one of an inorganic material and an organic material.

17. The method of claim 15 , wherein the first polyphosphate compound comprises amorphous calcium polyphosphate.

18. The method of claim 15 , comprising at least one of a polycarboxylate, a polysulfate, polysulfonates, a polyphosphate, a polyamine, a polyurea, a polyamide, a polyalkylene oxide diol, a polyalkylene oxide diamine, a polycarbonate, a polylactone, a polyethersulfone, a polyvinyl, a polypeptide, a polysaccharide, a polyurethane, a polysulfone, a polyester, polyethylene, polypropylene, polystyrene, polysilicone, poly(acrylonitrile-butadienestyrene), polybutadiene, polyisoprene, polymethylmethacrylate, polyvinylacetate, polyacrylonitrile, polyvinyl chloride, polyethylene terephtalate, cellulose, a polysilicone, a polyolefin, a polyvinyl derivative, a polypeptide derivative, poly(lactic-co-glycolic acid), and a polysaccharide derivative.

19. The method of claim 15 , comprising at least one of a carboxylate, a sulfate, a sulfonate, a phosphate, an amine, urea, an amide, an alkylene oxide diol, an alkylene oxide diamine, a carbonate, a lactone, an ethersulfone, a vinyl, a peptide, a dimethacrylate, a saccharide, a urethane, a sulfone, an ester, an ethylene, propylene, a styrene, silicone, acrylonitrile-butadienestyrene, butadiene, an isoprene, methylmethacrylate, vinylacetate, acrylonitrile, vinyl chloride, ethylene terephtalate, an olefin, a vinyl derivative, bisphenol A, a bisphenol A derivative, an oligosaccharide, a peptide derivative, lactic acid, glycolic acid, cyanoacrylate, a cyanoacrylate derivative, and a saccharide derivative.

20. The method of claim 15 , wherein the ratio is1:0.15 to 1:1.

Assignees

• Univ Wayne State

Inventors

• Ren Weiping
• Song Wei

Classifications

• A61L24/0063 Primary

  Phosphorus containing materials, e.g. apatite · CPC title

• C04B28/34

  containing cold phosphate binders · CPC title

• A61L2400/06

  Flowable or injectable implant compositions · CPC title

• A61L24/0052

  with an inorganic matrix · CPC title

• A61L24/02

  containing inorganic materials · CPC title