Azetidine-substituted pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2
US-12180196-B2 · Dec 31, 2024 · US
US10632202B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10632202-B2 |
| Application number | US-201715442152-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 24, 2017 |
| Priority date | Mar 4, 2016 |
| Publication date | Apr 28, 2020 |
| Grant date | Apr 28, 2020 |
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The present invention relates to compositions providing improved preservative efficacy. The present invention further relates to polyquaternium compound containing compositions having improved the antifungal activity. In certain embodiments, the present invention relates to ophthalmic compositions comprising a polyquaternium compound, a polyol or combination of polyols, borate compound, and an antimicrobial mixture comprising electrolytes and nutrients.
Opening claim text (preview).
What is claimed is: 1. A composition, comprising a formulation selected from: INGRED- A B C D IENT % w/w % w/w % w/w % w/w Tetrahydro- About 0.05 About 0.05 About 0.05 — zoline Hydrochloride Polyethylene — About 1.12 About 1.12 About 1.12 Glycol 400 Glycerin About 0.50 About 0.25 About 0.25 About 0.25 Hypromellose — About 0.20 — About 0.20 E3 2910 Hypromellose — — About 0.36 — E4M 2910 Boric Acid About 0.52 About 0.52 About 0.52 About 0.52 Sodium Borate About 0.06 About 0.06 About 0.06 About 0.06 Disodium About 0.027 About 0.027 About 0.027 About 0.027 Phosphate Sodium About About About About Citrate 0.0009 0.0009 0.0009 0.0009 Dihydrate Potassium About 0.18 About 0.18 About 0.18 About 0.18 Chloride Sodium About 0.15 About 0.12 About 0.12 About 0.12 Chloride 50% Aqueous About 0.057 About 0.056 About 0.056 About 0.056 Solution of Sodium Lactate Magnesium About 0.013 About 0.013 About 0.013 About 0.013 Chloride Glucose About 0.004 About 0.004 About 0.004 About 0.004 Glycine About About About About 0.00002 0.00002 0.00002 0.00002 Ascorbic Acid About About About About 0.00001 0.00001 0.00001 0.00001 Poly- About 0.003 About 0.003 About 0.003 About 0.003 quaternium 42 Purified Water QS QS QS QS total 100.00% 100.00% 100.00% 100.00%. 2. A composition, comprising a formulation selected from: A B INGREDIENT % w/w % w/w Tetrahydrozoline Hydrochloride 0.05 0.05 Polyethylene Glycol 400 0.40 — Polysorbate 80 — 1.0
Boron compounds · CPC title
with oxygen as the ring hetero atom · CPC title
containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids · CPC title
Quaternary ammonium compounds · CPC title
Acyclic compounds · CPC title
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