Sheet packs and methods for treating skin

Patent metadata

Field	Value
Publication number	US-10631616-B2
Application number	US-201715730904-A
Country	US
Kind code	B2
Filing date	Nov 15, 2017
Priority date	Jul 28, 2015
Publication date	Apr 28, 2020
Grant date	Apr 28, 2020

Abstract

A sheet pack comprising an absorbent layer impregnated with a treatment composition containing at least one ingredient that when topically applied to skin stimulates a gene that is variably expressed over a 24 hour period in native untreated skin cells; the sheet pack contained in a package with user instructions to topically apply the sheet pack to the skin at a time when the gene that is stimulated by the ingredient is being maximally expressed in native untreated skin cells; and methods for treating skin and methods for making a sheet pack.

First claim

The invention claimed is:

1. A sheet pack in the form of a laminate having a thickness of 0.2 to 1.5 mm comprising a skin penetration enhancing impermeable layer comprised of metallic foil having a thickness ranging from 2 to 15 microns permanently bonded to an absorbent layer comprised of cotton pulp with a heat activated bonding agent which is a thermoplastic material having a melting point ranging from 200 to 300° C., where the absorbent layer is impregnated with an aqueous based treatment composition having a viscosity of 2 to 1,000 centipoise at 25° C., containing an ingredient selected from the group consisting of (a) a CLOCK gene activator, (b) a PER gene activator, (c) a BMAL gene activator, (d) a CRY gene activator, or (e) combinations thereof; wherein the absorbent layer side of the sheet pack laminate is topically applied to the skin for a period of 1 to 60 minutes wherein the skin penetration of the treatment composition is improved compared to a sheet pack containing the same absorbent layer but having no impermeable layer permanently bonded to the absorbent layer.

2. The sheet pack of claim 1 wherein the sheet pack contained in a package with user instructions.

3. The sheet pack of claim 1 wherein the absorbent layer has one or more of the following specifications:
(a) absorbs water from 0.03 to 2.5 ml/gram after 5 seconds per 1 gram measured by the Larose method;
(b) a thickness ranging from 0.1 to 1.0 mm;
(c) a bending resistance of 1.0 to 2.0 mm.m 2 /gram;
(d) a drape co-efficient ranging from 1 to 70%;
(e) a KES bending rigidity B value of less than or equal to 0.20 gf/cm 2 /cm; and
(f) a co-efficient of friction of less than 0.45 MIU.

4. The sheet pack of claim 1 wherein the absorbent layer is bonded to the impermeable layer by a bonding agent that is a synthetic polymer having melting point ranging from 221 to 248° C. and a specific gravity of 915 to 935 kg/m 3 .

5. The sheet pack of claim 4 wherein the impermeable layer has one or more of the following specifications:
(a) from 98 to 100% aluminum;
(b) a melting point of greater than 650° C.; and
(c) a specific gravity of 2.5 to 3.0.

6. The sheet pack of claim 1 wherein the impermeable layer causes the treatment composition to show at least a 10% improvement in skin penetration of the treatment composition into the treatment surface when compared to the skin penetration of the treatment composition into the treatment surface with a sheet pack containing the same absorbent layer but with no impermeable layer being bonded to the absorbent layer.

7. The sheet pack of claim 1 wherein the absorbent layer is bonded to the impermeable layer by a bonding agent which is low density polyethylene.

8. The sheet pack of claim 1 wherein the skin treatment composition comprises a PER gene activator and is applied to skin when the PER gene is being maximally expressed in skin cells.

9. The sheet pack of claim 1 wherein the skin treatment composition comprises a BMAL or CRY gene activator and is applied to skin when the BMAL or CRY gene respectively is being maximally expressed in skin cells.

10. The sheet pack of claim 1 where the activator of CLOCK, PER, CRY, or BMAL is one or more of:
Cichoric acid;
Echinacea extract;
Tripeptide-32;
Tetrapeptide-26; or
an Autophagy activator.

11. The sheet pack of claim 1 wherein the additional skin treatment active is:
(a) a DNA repair enzyme selected from an enzyme that repairs 8-oxo-guanine base damage, an enzyme that repairs T-T-dimers, an enzyme that repairs 6-methyl guanine base damage, T4 endonuclease, Base Excision Repair enzymes, Mismatch Excision Repair enzymes, Nucleotide Excision Repair enzymes, DNA Polymerases, DNA Helicases, and combinations thereof;
(b) a probiotic microorganism selected from Bifidobacteriales, Saccharomyces or Lactobacillales genera;
(c) a proteasome activator selected from algin, alginates, hydrolyzed algin, molasses extract, Trametes extracts, Oleo Europa fruit extract, Acacia Senegal extract, plankton extract, arginine ferulate and combinations thereof;
(d) or combinations thereof.

12. The sheet pack of claim 1 for treating facial or body skin.

13. The sheet pack of claim 2 wherein the user instructions are to apply the sheet pack to the skin at a time ranging from 18:00 to 24:00 hours.

14. The sheet pack of claim 2 wherein the user instructions are to apply the sheet pack to the skin at a time ranging from 20:00 to 24:00 hours.

15. The sheet pack of claim 2 wherein the user instructions are to apply the sheet pack to the skin at a time ranging from 18:00 to 24:00 hours for 1 to 60 minutes.

16. A method for making a sheet pack comprising the steps of:
(i) identifying a gene selected from the group consisting of (a) a CLOCK gene, (b) a PER gene, (c) a BMAL gene, (d) a CRY gene, or (e) combinations thereof that is variably expressed over a 24 hour period in skin cells;
(ii) forming the sheet pack in the form of a laminate having a thickness of 0.2 to 1.5 mm comprised of skin penetration enhancing impermeable metallic foil layer having a thickness ranging from 2 to 15 microns permanently bonded to a fabric absorbent layer comprising cotton pulp with a heat activated bonding agent which is a thermoplastic material having a melting point ranging from 200 to 300° C.; and
(iii) impregnating the absorbent layer with an aqueous based skin treatment composition having a viscosity of 2 to 1,000 centipoise at 25° C. containing an ingredient selected from the group consisting of (a) a CLOCK gene activator, (b) a PER gene activator, (c) a BMAL gene activator, (d) CRY gene activator, or (e) combinations thereof wherein the skin penetration of the treatment composition is improved compared to a sheet pack containing the same absorbent layer but having no impermeable layer permanently bonded to the absorbent layer when topically applied to skin for a period of 1 to 60 minutes.

17. The method of claim 16 wherein the gene that is variably expressed over a 24 hour period is maximally expressed at times ranging from 18:00 to 24:00 hours and is one or more of PER, CLOCK, BMAL, or CRY.

Assignees

• Elc Man Llc

Inventors

• Carullo Anne
• Palmer Quintano Jennifer
• Kassouf Joyce
• Pernodet Nadine
• Collins Donald
• Layman Dawn
• Hafkin Allan
• Fontanet Osvaldo

Classifications

• A61L2300/25

  Peptides having up to 20 amino acids in a defined sequence · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61K36/28 Primary

  Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea · CPC title

• A61K8/362

  Polycarboxylic acids · CPC title

• A45D44/22

  Face shaping devices, e.g. chin straps; Wrinkle removers, e.g. stretching the skin (skin stretchers for shaving A45D27/38) · CPC title