Method and apparatus for image-directed nerve growth

Patent metadata

Field	Value
Publication number	US-10627461-B2
Application number	US-201514874857-A
Country	US
Kind code	B2
Filing date	Oct 5, 2015
Priority date	Oct 3, 2014
Publication date	Apr 21, 2020
Grant date	Apr 21, 2020

Abstract

Disclosed embodiments are directed to promoting nerve growth through one or more mechanisms using an apparatus to rapidly change magnetic fields.

First claim

We claim:

1. A method of guiding growth of at least one nerve in a body part, the method comprising:
sequentially moving at least one particle in order to continue to direct said growth in the direction of the particle,
wherein motion of the at least one particle is caused by application of magnetic gradients,
wherein the at least one particle is located and sequentially moved external to the at least one nerve.

2. The method of claim 1 , further comprising generating at least one magnetic gradient using at least one coil under control of a control unit, so as to control the at least one coil to generate and transmit radio frequency energy into the body part to apply the magnetic gradients;
detecting radio frequency energy received from the body part to obtain imaging data regarding the body part so as to perform magnetic resonance imaging of at least one nerve end in the body part;
controlling the sequential movement of the at least one particle based on the obtained imaging data.

3. The method of claim 1 , wherein the body part is the brain.

4. The method of claim 1 , wherein the body part is the spinal cord.

5. The method of claim 1 , wherein the body part is a peripheral nerve.

6. The method of claim 1 , in which one or more of the applied magnetic gradients arises or falls in less than 10 microseconds so as not to cause discomfort.

7. The method of claim 1 , wherein the at least one particle elutes at least one chemical that affects nerve growth.

8. The method of claim 1 , wherein the application of magnetic gradients to move and/or concentrate the at least one particle is interleaved with the application of magnetic fields to visualize nerves or collections of nerves.

9. A method of guiding growth of at least one nerve in a body part, the method comprising:
sequentially moving at least one particle in order to direct said growth,
wherein motion of the at least one particle is caused by application of magnetic gradients,
wherein the at least one particle generates an electric field in the vicinity of a nerve in order to affect nerve growth.

10. The method of claim 9 , where the electric field is generated through a fuel-cell in the particle.

11. The method of claim 9 , wherein the electric field is generated through motion of a piezoelectric generator that is actuated by application of a magnetic field external to the body part.

12. A method of guiding growth of at least one nerve in a body part, the method comprising:
sequentially moving at least one particle in order to direct said growth,
wherein motion of the at least one particle is caused by application of magnetic gradients,
wherein the electric field is generated through motion of one or more portions of a tribological generator that is actuated by application of a magnetic field external to the body part.

13. The method of claim 12 , further comprising generating at least one magnetic gradient using at least one coil under control of a control unit, so as to control the at least one coil to generate and transmit radio frequency energy into the body part to apply the magnetic gradients;
detecting radio frequency energy received from the body part to obtain imaging data regarding the body part so as to perform magnetic resonance imaging of at least one nerve end in the body part;
controlling the sequential movement of the at least one particle based on the obtained imaging data.

14. The method of claim 12 , wherein the body part is the brain.

15. The method of claim 12 , wherein the body part is the spinal cord.

16. The method of claim 12 , wherein the body part is a peripheral nerve.

17. The method of claim 12 , in which one or more of the applied magnetic gradients arises or falls in less than 10 microseconds so as not to cause discomfort.

18. The method of claim 12 , wherein the at least one particle elutes at least one chemical that affects nerve growth.

19. The method of claim 12 , wherein the application of magnetic gradients to move and/or concentrate the at least one particle is interleaved with the application of magnetic fields to visualize nerves or collections of nerves.

Assignees

• Weinberg Medical Physics Llc
• Weinberg Medical Physics Inc

Inventors

• Weinberg Irving N
• Mair Lamar Odell
• Nudo Randolph

Classifications

• A61N2/00

  Magnetotherapy · CPC title

• A61N1/40

  Applying electric fields by inductive or capacitive coupling (microwave apparatus A61N5/00); {Applying radio-frequency signals} · CPC title

• G01R33/288 Primary

  Provisions within MR facilities for enhancing safety during MR, e.g. reduction of the specific absorption rate [SAR], detection of ferromagnetic objects in the scanner room · CPC title