Peptides for targeting gastric cancer, and medical use tehreof

Patent metadata

Field	Value
Publication number	US-10627402-B2
Application number	US-201816149142-A
Country	US
Kind code	B2
Filing date	Oct 2, 2018
Priority date	Nov 18, 2014
Publication date	Apr 21, 2020
Grant date	Apr 21, 2020

Abstract

Provided is a peptide for targeting gastric cancer, a composition for diagnosing radioresponsiveness-dependent gastric cancer using the peptide, and a drug delivery use of the peptide, wherein a functional peptide capable of targeting cancer has been discovered so as to implement personalized diagnosis and treatment for individual patients having cancer, consideration of problems occurring during treatment in which treatment cases of respective patients differ due to different therapeutic responses resulting from genetic differences in the individual patients.

First claim

What is claimed is:

1. A method for diagnosing radio-sensitive gastric cancer, comprising:
irradiating radiation to a patient having a gastric cancer;
applying a composition comprising a peptide consisting of amino acid sequence selected from the group consisting of SEQ ID NOs: 1 to 3 to the patient having the gastric cancer;
detecting the peptide specific to an irradiated gastric cancer tissue; and
diagnosing the patient as having the radio-sensitive gastric cancer if the peptide being specific to the irradiated gastric cancer tissue is detected.

2. The method of claim 1 , wherein the peptide is labeled with one selected from the group consisting of a chromogenic enzyme, a radioactive isotope, a chromopore, and a luminescent or fluorescent material.

3. A method for diagnosing radio-sensitive gastric cancer, comprising:
obtaining a gastric cancer tissue sample from a patient;
transplanting the gastric cancer tissue sample into an experimental animal;
irradiating radiation to the transplanted experimental animal;
applying a composition comprising a peptide consisting of amino acid sequence selected from the group consisting of SEQ ID NOs: 1 to 3 to the irradiated experimental animal;
detecting the peptide specific to an irradiated gastric cancer tissue; and
diagnosing the patient as having the radio-sensitive gastric cancer if the peptide being specific to the irradiated gastric cancer tissue is detected.

Assignees

• Univ Ulsan Found Ind Coop

Inventors

• Choi Eun Kyung
• Jeong Seong-Yun
• Song Si Yeol
• Lee Kyoung Jin
• Shin Seol Hwa
• Ju Eun Jin

Classifications

• A61K49/00

  Preparations for testing in vivo · CPC title

• A61K49/0008

  Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure · CPC title

• G01N33/58

  involving labelled substances (G01N33/53 takes precedence) · CPC title

• G01N33/00

  Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00 · CPC title

• C07K7/08

  having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title