Compositions and methods for improving Rebaudioside X solubility

Patent metadata

Field	Value
Publication number	US-10626136-B2
Application number	US-201615171400-A
Country	US
Kind code	B2
Filing date	Jun 2, 2016
Priority date	Dec 19, 2012
Publication date	Apr 21, 2020
Grant date	Apr 21, 2020

Abstract

Polymorphic and amorphous forms of Rebaudioside X and methods for preparing the same are provided herein. Also provided herein are Rebaudioside X complexes and methods for preparing the same. Sweetener compositions and sweetened compositions comprising Rebaudioside X forms and Rebaudioside X complexes are described, as well as and methods of their preparation. Methods of improving the flavor and/or temporal profile of sweetenable compositions, such as beverages, are also provided herein.

First claim

What Is Claimed Is:

1. A method for preparing amorphous Rebaudioside X comprising:
(i) heating a mixture consisting of water and a steviol glycoside mixture comprising Rebaudioside X in an amount greater than about 80% by weight on a dry basis, wherein the Rebaudioside X is in substantially pure crystalline form, to a temperature between about 100° C. to about 130° C.;
(ii) cooling the mixture; and
(iii) removing the water from the mixture to provide a steviol glycoside mixture comprising Rebaudioside X in an amount greater than about 80% by weight on a dry basis, wherein the Rebaudioside X is in substantially pure amorphous form.

2. The method of claim 1 , wherein the Rebaudioside X in (i) is Form A Rebaudioside X.

3. The method of claim 1 , wherein the mixture is heated to a temperature from about 120° C. to about 125° C.

4. The method of claim 1 , wherein the mixture in (ii) is cooled to room temperature such that crash precipitation does not occur.

5. The method of claim 4 , wherein the mixture is cooled at a rate of about 1° C. per minute.

6. The method of claim 1 , wherein the water is removed by a process selected from the group consisting of decantation, centrifugation, filtration, evaporation, vacuum, spray-drying and a combination thereof.

7. The method of claim 6 , wherein the water is removed by spray-drying.

8. The method of claim 1 , wherein the amorphous Rebaudioside X has a solubility of about 0.3% or greater.

9. The method of claim 1 , wherein the amorphous Rebaudioside X has a solubility of about 1.0% or greater.

10. A method for preparing amorphous Rebaudioside X comprising:
(i) heating a mixture consisting of ethanol and a steviol glycoside mixture comprising Rebaudioside X in an amount greater than about 80% by weight on a dry basis, wherein the Rebaudioside X is in substantially pure crystalline form, to a temperature between about 70 ° C. to about 120 ° C.;
(ii) cooling the mixture; and
(iii) removing the ethanol from the mixture to provide a steviol glycoside mixture comprising Rebaudioside X in an amount greater than about 80% by weight on a dry basis wherein the Rebaudioside X is in substantially pure amorphous form.

11. The method of claim 10 , wherein the Rebaudioside X in (i) is Form A Rebaudioside X.

12. The method of claim 10 , wherein the mixture is heated to a temperature between about 80° C. and about 85° C.

13. The method of claim 10 , wherein the mixture in (ii) is cooled to about room temperature such that crash precipitation does not occur.

14. The method of claim 10 , wherein the ethanol is removed by a process selected from the group consisting of decantation, centrifugation, filtration, evaporation, vacuum, spray-drying and a combination thereof.

15. The method of claim 14 , wherein the ethanol is removed by vacuum.

16. The method of claim 10 , wherein the amorphous Rebaudioside X has a solubility of about 0.3% or greater.

17. The method of claim 10 , wherein the amorphous Rebaudioside X has a solubility of about 1.0% or greater.

Assignees

• Coca Cola Co
• Purecircle Sdn Bhd

Inventors

• Prakash Indra
• Markosyan Avetik
• Chaturvedula Venkata Sai Prakash
• Ma Gil

Classifications

• C07H15/24

  Condensed ring systems having three or more rings · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• C07H15/256 Primary

  Polyterpene radicals · CPC title

• C07C31/24

  Tetrahydroxylic alcohols, e.g. pentaerythritol · CPC title

• C08B37/0015

  Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes · CPC title