Modulators of ATP-binding cassette transporters

Patent metadata

Field	Value
Publication number	US-10626111-B2
Application number	US-201816197732-A
Country	US
Kind code	B2
Filing date	Nov 21, 2018
Priority date	Jan 30, 2004
Publication date	Apr 21, 2020
Grant date	Apr 21, 2020

Abstract

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

First claim

What is claimed is:

1. A compound having the chemical structure:

Assignees

• Vertex Pharma

Inventors

• Hadida Ruah Sara S
• Hamilton Matthew M
• Miller Mark
• Grootenhuis Peter D J

Classifications

• A61P19/08

  for bone diseases, e.g. rachitism, Paget's disease · CPC title

• A61P21/02

  Muscle relaxants, e.g. for tetanus or cramps · CPC title

• A61P5/16

  for decreasing, blocking or antagonising the activity of the thyroid hormones · CPC title

• C07D405/12 Primary

  linked by a chain containing hetero atoms as chain links · CPC title

• A61K31/4525

  containing a five-membered ring with oxygen as a ring hetero atom · CPC title