Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury

Patent metadata

Field	Value
Publication number	US-10626071-B2
Application number	US-201815961085-A
Country	US
Kind code	B2
Filing date	Apr 24, 2018
Priority date	Feb 10, 2011
Publication date	Apr 21, 2020
Grant date	Apr 21, 2020

Abstract

Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.

First claim

What is claimed is:

1. A composition comprising:
a compound having the formula:

wherein
R is S;
R1 is —OR5 where R5 is H or CH 3 ;
R2 is phenyl; and
R3 is 3 methylene groups,
or a pharmaceutically acceptable salt thereof, in an amount effective to increase renal progenitor cell production in a kidney of a patient; and

a pharmaceutically-acceptable excipient.

2. The composition of claim 1 , wherein the compound has the formula:

or a pharmaceutically acceptable salt thereof.

3. The composition of claim 1 , comprising a cyclodextrin complexed with the compound.

4. The composition of claim 1 , wherein the compound is 4-(phenylthio)butanoic acid.

5. A method, comprising administering the composition of claim 1 to a subject.

6. A method, comprising administering the composition of claim 2 to a subject.

7. A method, comprising administering the composition of claim 3 to a subject.

8. A method, comprising administering the composition of claim 4 to a subject.

9. A method of increasing renal progenitor cell production in a kidney of a patient, the method comprising administering the composition of claim 1 to the patient.

10. A method of increasing renal progenitor cell production in a kidney of a patient, the method comprising administering the composition of claim 2 to the patient.

11. A method of increasing renal progenitor cell production in a kidney of a patient, the method comprising administering the composition of claim 3 to the patient.

12. A method of increasing renal progenitor cell production in a kidney of a patient, the method comprising administering the composition of claim 4 to the patient.

Assignees

• Univ Of Pittsburgh—Of The Commonwealth System Of Higher Education

Inventors

• Day Billy W
• Hukriede Neil

Classifications

• C07C323/56

  the carbon skeleton containing six-membered aromatic rings · CPC title

• C07C317/44

  having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton · CPC title

• A61P13/12

  of the kidneys · CPC title

• B01D15/1821 Primary

  Simulated moving beds · CPC title

• C07C229/18

  the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings · CPC title