Bioresorbable nonwoven fabric made of gelatin

Patent metadata

Field	Value
Publication number	US-10624985-B2
Application number	US-67821908-A
Country	US
Kind code	B2
Filing date	Sep 17, 2008
Priority date	Sep 18, 2007
Publication date	Apr 21, 2020
Grant date	Apr 21, 2020

Abstract

A nonwoven fabric includes fibers of a fiber raw material including gelatin, the fibers including at least one of an antimicrobially effective substance and an antibiotic, wherein the fibers are produced by rotational spinning.

First claim

The invention claimed is:

1. A nonwoven fabric, comprising:
fibers of a fiber raw material consisting essentially of at least one gelatin or derivative of gelatin,
wherein the fibers comprise an antimicrobially effective substance, an antibiotic, or a mixture of two or more of any of these,
wherein the fibers have a diameter from 0.3 to 500 μm,
wherein the fibers are produced by rotational spinning of the fiber raw material, then drawing spun fiber raw material through circular, oval, or rectangular passages, then guiding discharged fibers from the passages in a directed and non-contacting manner,
wherein at least some of the fibers are twisted with one another, interlaced with one another, or have a twisted structure, so as to bond to one another as laid without further bonding measures,
wherein the fabric has an open pore structure and an air permeability of at least 0.5 L/min·cm 2 .

2. The nonwoven fabric as recited in claim 1 , wherein at least some of the fibers are interlaced with one another and form at least one fiber bundle.

3. The nonwoven fabric as recited in claim 1 , wherein the fibers consist of:
the at least one gelatin or derivative of gelatin; and
the antimicrobial substance, the antibiotic, or the mixture.

4. The nonwoven fabric as recited in claim 1 , wherein the antimicrobially effective substance, the antibiotic, or the mixture
is homogenously distributed in the fibers, and/or
present in the fibers at a nanoscale level, and/or
distributed on the fibers.

5. The nonwoven fabric as recited in claim 1 , wherein the antimicrobially effective substance is present and comprises silver.

6. The nonwoven fabric as recited in claim 1 , further comprising:
nanofibers, comprising gelatin and/or a gelatin derivative, having a diameter of not more than 100 nm, which nanofibers are not electrically spun.

7. The nonwoven fabric as recited in claim 1 , wherein the fabric has a tensile strength of at least 0.15 N/mm 2 at a specific weight per unit area from 140 to 180 g/m 2 in a dry state, and
wherein the fabric has an elongation at break in a hydrated state of 150% to 200%.

8. A method for producing the nonwoven fabric of claim 1 , the method comprising:
introducing the fiber raw material into a container;
introducing the antimicrobially effective substance, the antibiotic, or the mixture into the container;
rotating the container so as to fluidize the fiber raw material and discharge the fluidized fiber raw material from the container by centripetal forces so as to form the fibers; and
joining the fibers together in a nonwoven manner to provide the nonwoven fabric.

9. The method as recited in claim 8 , further comprising:
guiding the fibers being discharged from the container in a directed and non-contacting manner.

10. The method as recited in claim 9 , wherein the guiding is performed using a suction device.

11. The method as recited in claim 8 , wherein the fluidized fiber raw material is discharged through passages having a diameter of up to 500 μm.

12. The method as recited in claim 8 , wherein the rotating is carried out at a speed of up to 25,000 revolutions per minute.

13. The method as recited in claim 8 , wherein the container can be heated to a temperature of 300° C.

14. The method as recited in claim 8 , further comprising:
laying the fibers on a laying device,
wherein an electrical potential difference exists between the laying device and the container.

15. The method as recited in claim 8 , further comprising:
contacting the nonwoven fabric with a drug suitable for wound healing.

16. The method as recited in claim 8 , further comprising:
disposing the nonwoven fabric onto an end of a rod element so as to form a swab.

17. A method for producing the nonwoven fabric of claim 1 , the method comprising:
rotating a container comprising the fiber raw material in fluidized form, thereby discharging the fluidized fiber raw material from the container by centripetal forces so as to form the fibers;
joining the fibers together to provide the nonwoven fabric; and
disposing the antimicrobially effective substance, the antibiotic, or the mixture on the fibers.

18. A swab, comprising:
a rod element; and
the nonwoven fabric of claim 1 ,
wherein the nonwoven fabric is disposed onto an end of the rod element.

19. The nonwoven fabric as recited in claim 1 , wherein the fibers are made by a process that comprises fluidizing gelatin in a solution comprising water.

20. The nonwoven fabric as recited in claim 5 , wherein the antimicrobially effective substance further comprises gold.

21. A nonwoven fabric, comprising:
fibers substantially comprising gelatin; and
an antimicrobially effective substance, an antibiotic, or a mixture of two or more of any of these,
wherein the fibers have a diameter from 0.3 to 500 μm,
wherein at least some of the fibers are twisted or interlaced so as to bond to one another as laid without further bonding measures, and wherein the fabric has an air permeability of at least 0.5 L/min·cm 2 .

22. The nonwoven fabric as recited in claim 21 , further comprising:
nanofibers, substantially comprising gelatin, having a diameter of not more than 100 nm, which nanofibers are not electrically spun.

23. The nonwoven fabric as recited in claim 21 , wherein the fabric has a tensile strength of at least 0.15 N/mm 2 at a specific weight per unit area from 140 to 180 g/m 2 in a dry state, and
wherein the fabric has an elongation at break in a hydrated state of 150% to 200%.

24. A nonwoven fabric, comprising:
fibers substantially comprising gelatin, a gelatin derivative, or a mixture of two or more of these; and
an antimicrobially effective substance, an antibiotic, or a mixture of two or more of any of these,
wherein the fibers have a diameter up to 500 μm, and
wherein the fibers are rotationally spun, and some of the fibers are twisted or interlaced so as to bond to one another without further bonding measures, and wherein the fabric has an air permeability of at least 0.5 L/min·cm 2 .

25. The nonwoven fabric as recited in claim 1 , wherein the fabric has a tensile strength of at least 0.15 N/mm 2 at a specific weight per unit area from 140 to 180 g/m 2 in a dry state, and
wherein the fabric has an elongation at break in a hydrated state of 150% to 200%.

26. The nonwoven fabric as recited in claim 24 , wherein the fibers comprising nanofibers having a diameter of not more than 100 nm, which nanofibers are not electrically spun.

Assignees

• Reibel Denis
• Walter Claudio
• Altmueller Bernd
• Freudenberg Carl Kg

Inventors

• Reibel Denis
• Walter Claudio
• Altmueller Bernd

Classifications

• D01D5/18

  by means of rotating spinnerets · CPC title

• A61L15/32

  Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin {(A61L15/225 takes precedence)} · CPC title

• A61L2300/404

  Biocides, antimicrobial agents, antiseptic agents · CPC title

• D04H1/02

  Cotton wool; Wadding · CPC title

• A61L2300/104

  Silver, e.g. silver sulfadiazine · CPC title