Methods and systems for optothermal particle control

Patent metadata

Field	Value
Publication number	US-10620121-B2
Application number	US-201716094705-A
Country	US
Kind code	B2
Filing date	Apr 19, 2017
Priority date	Apr 19, 2016
Publication date	Apr 14, 2020
Grant date	Apr 14, 2020

Abstract

Disclosed herein are methods comprising illuminating a first location of a plasmonic substrate with electromagnetic radiation, wherein the electromagnetic radiation comprises a wavelength that overlaps with at least a portion of the plasmon resonance energy of the plasmonic substrate. The plasmonic substrate can be in thermal contact with a liquid sample comprising a plurality of particles, the liquid sample having a first temperature. The methods can further comprise generating a confinement region at a location in the liquid sample proximate to the first location of the plasmonic substrate, wherein at least a portion of the confinement region has a second temperature that is greater than the first temperature such that the confinement region is bound by a temperature gradient. The methods can further comprise trapping at least a portion of the plurality of particles within the confinement region.

First claim

What is claimed is:

1. A method comprising:
illuminating a first location of a plasmonic substrate with electromagnetic radiation at a power density of 1 mW/μm 2 or less;
wherein the electromagnetic radiation comprises a wavelength that overlaps with at least a portion of the plasmon resonance energy of the plasmonic substrate; and
wherein the plasmonic substrate is in thermal contact with a liquid sample comprising a plurality of particles, the liquid sample having a first temperature;

thereby:
generating a first confinement region at a location in the liquid sample proximate to the first location of the plasmonic substrate by plasmon-enhanced photothermal effects, wherein at least a portion of the first confinement region has a second temperature that is greater than the first temperature such that the first confinement region is bound by a temperature gradient; and
trapping at least a first portion of the plurality of particles within the first confinement region, said first portion of the plurality of particles trapped within the first confinement region being a first trapped portion of the plurality of particles;

subsequently, illuminating a second location of the plasmonic substrate thereby:
generating a second confinement region at a location in the liquid sample proximate to the second location of the plasmonic substrate by plasmon-enhanced photothermal effects, wherein at least a portion of the second confinement region has a third temperature that is greater than the first temperature such that the second confinement region is bound by a temperature gradient; and
translocating at least a portion of the first trapped portion of the plurality of particles from the first confinement region to the second confinement region, trapping at least a second portion of the plurality of particles within the second confinement region to form a second trapped portion of the plurality of particles, or a combination thereof.

2. The method of claim 1 , wherein the electromagnetic radiation is provided by a light source and the light source is a laser.

3. The method of claim 2 , wherein the light source is configured to illuminate a mirror and the mirror is configured to reflect the electromagnetic radiation from the light source to illuminate the first location and/or the second location of the plasmonic substrate.

4. The method of claim 2 , wherein the light source is configured to illuminate a digital micromirror device, the digital micromirror device comprising a plurality of mirrors, and wherein the digital micromirror device is configured to reflect the electromagnetic radiation from the light source to illuminate the first location and/or the second location of the plasmonic substrate.

5. The method of claim 1 , wherein the plasmonic substrate comprises a plurality of plasmonic particles and the plurality of plasmonic particles comprise a metal selected from the group consisting of Au, Ag, Pd, Cu, Cr, Al, and combinations thereof.

6. The method of claim 5 , wherein the plurality of plasmonic particles have an average particle size of from 10 nm to 500 nm.

7. The method of claim 5 , wherein each plasmonic particle within the plurality of plasmonic particles of the plasmonic substrate is separated from its neighboring plasmonic particles by an average distance of from 3 nm to 1500 nm.

8. The method of claim 1 , wherein the plurality of particles in the liquid sample comprise a plurality of polymer particles, a plurality of metal particles, a plurality of semiconductor particles, a plurality of biological cells, or a combination thereof.

9. The method of claim 1 , wherein the first trapped portion of the plurality of particles, the second trapped portion of the plurality of particles, or a combination thereof are trapped at a trapping speed of from 200 nm/s to 50 μm/s.

10. The method of claim 1 , wherein the first trapped portion of the plurality of particles, the second trapped portion of the plurality of particles, or a combination thereof are not damaged during the trapping.

11. The method of claim 1 , wherein the first confinement region and/or the second confinement region has a diameter of from 500 nm to 100 μm.

12. The method of claim 1 , wherein the first trapped portion of the plurality of particles is one particle, the second trapped portion of the plurality of particles is one particle, or a combination thereof.

13. The method of claim 1 , wherein the first temperature is from 273 K to 343 K.

14. The method of claim 1 , wherein the second temperature is greater than the first temperature by from 3 K to 20 K.

15. The method of claim 1 , wherein the first trapped portion of the plurality of particles, the second trapped portion of the plurality of particles, or a combination thereof are trapped by convection, a thermophoretic force, an optical force, or combinations thereof.

16. The method of claim 1 , wherein the plasmonic substrate is translocated to illuminate the second location; wherein the electromagnetic radiation is provided by a light source, and the light source is translocated to illuminate the second location; wherein the electromagnetic radiation is provided by a light source, the light source being configured to illuminate a mirror and the mirror is configured to reflect the electromagnetic radiation from the artificial light source to illuminate the plasmonic substrate, and the mirror is translocated to illuminate the second location; or a combination thereof.

17. A patterned sample made using the methods of claim 1 .

18. A method of use of the patterned sample of claim 17 , wherein the patterned sample is used for single-particle sensing, single-cell analysis, tissue engineering, functional optical devices, intercellular communication, cell differentiation, immunological interaction, disease diagnosis, or combinations thereof.

19. A system comprising:
a plasmonic substrate in thermal contact with a liquid sample comprising a plurality of particles, the liquid sample having a first temperature;
a light source configured to illuminate the plasmonic substrate at a first location with electromagnetic radiation at a power density of 1 mW/μm 2 or less and at a wavelength that overlaps with at least a portion of the plasmon resonance energy of the plasmonic substrate;
thereby:
generating a first confinement region at a location in the liquid sample proximate to the first location of the plasmonic substrate by plasmon-enhanced photothermal effects, wherein at least a portion of the first confinement region has a second temperature that is greater than the first temperature such that the first confinement region is bound by a temperature gradient; and
trapping at least a first portion of the plurality of particles within the first confinement region, said first portion of the plurality of particles trapped within the first confinement region being a first trapped portion of the plurality of particles; and

a means for translocating the plasmonic substrate and/or the light source, such that the light source is subsequently configured to illuminate the plasmonic substrate at a second location,
thereby:
generating a second confinement region at a location in the liquid sample proximate to the second location of the plasmonic substrate by plasmon-enhanced photothermal effects, wherein at least a portion of the second confinement region has a third temperature that is greater than the first temperature such that the second confinement region is bound by a temperature gradient; and
translocating at least a portion of the

Assignees

• Univ Texas

Inventors

• Zheng Yuebing
• Lin Linhan
• Peng Xiaolei

Classifications

• G02B5/00

  Optical elements other than lenses (light guides G02B6/00; optical logic elements G02F3/00) · CPC title

• B01L2400/0454

  radiation pressure, optical tweezers · CPC title

• G01N21/554 Primary

  detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance · CPC title

• G02B21/32

  Micromanipulators structurally combined with microscopes · CPC title

• G02B5/008

  Surface plasmon devices (diffractive gratings with a pitch less than or comparable to the wavelength G02B5/1809; surface plasmons in integrated optics G02B6/1226; optical analysis of materials by means of surface plasmons G01N21/553) · CPC title