Nutritional compositions containing phosphatidylethanolamine, sphingomyelin and docosahexaenoic acid

Patent metadata

Field	Value
Publication number	US-10617701-B2
Application number	US-201514796372-A
Country	US
Kind code	B2
Filing date	Jul 10, 2015
Priority date	Jul 10, 2015
Publication date	Apr 14, 2020
Grant date	Apr 14, 2020

Abstract

The present disclosure provides a composition and method for promoting functional neuronal development in pediatric subjects. The composition comprises in some embodiments up to about 7 g/100 Kcal of a fat or lipid source; up to about 5 g/100 Kcal of a protein source; about 3 mg/100 Kcal to about 50 mg/100 Kcal of phosphatidylethanolamine; about 0.15 mg/100 Kcal to about 75 mg/100 Kcal of sphingomyelin; and about 5 mg/100 Kcal to about 75 mg/100 Kcal of docosahexaenoic acid. The methods comprise, in some embodiments, administering the aforementioned composition to a pediatric subject.

First claim

What is claimed is:

1. A method for promoting neuronal maturation in a fetus comprising:
administering to a female subject pregnant with the fetus a maternal nutritional supplement comprising:
about 3 mg/100 Kcal to about 50 mg/100 Kcal of phosphatidylethanolamine;
about 0.15 mg/100 Kcal to about 75 mg/100 Kcal of sphingomyelin;
about 10 mg/100 Kcal to about 200 mg/100 Kcal of lactoferrin;
about 0.015 g/100 Kcal to about 0.15 g/100 Kcal of a prebiotic composition, wherein the prebiotic composition comprises polydextrose, galactooligosaccharide or a combination thereof; and
about 5 mg/100 Kcal to about 75 mg/100 Kcal of docosahexaenoic acid.

2. The method of claim 1 , wherein the maternal nutritional supplement further comprises up to about 7 g/100 Kcal of a fat or lipid source; and up to about 5 g/100 Kcal of a protein source.

3. The method of claim 1 , wherein polydextrose and galactooligosaccharide comprise at least about 20% of the prebiotic composition.

4. The method of claim 1 , wherein the maternal nutritional supplement further comprises Lactobacillus rhamnosus GG.

5. The method of claim 1 , wherein the maternal nutritional supplement further comprises arachidonic acid, wherein arachidonic acid and docosahexaenoic acid are present in a weight ratio ranging from about 1:3 to 9:1.

6. The method of claim 1 , wherein the maternal nutritional supplement further comprises human milk oligosaccharides.

7. The method of claim 1 , wherein the phosphatidylethanolamine and sphingomyelin are provided by a milk fat globular membrane-enriched ingredient.

8. The method of claim 1 , wherein the maternal nutritional supplement further comprises a carbohydrate source comprising lactose.

9. A method for promoting neuronal maturation in an infant comprising:
a) administering to a lactating female subject a nutritional supplement comprising:
about 3 mg/100 Kcal to about 50 mg/100 Kcal of phosphatidylethanolamine;
about 0.15 mg/100 Kcal to about 75 mg/100 Kcal of sphingomyelin;
about 10 mg/100 Kcal to about 200 mg/100 Kcal of lactoferrin;
about 0.015 mg/100 Kcal to about 0.15 g/100 Kcal of a prebiotic composition, wherein the prebiotic composition comprises polydextrose, galactooligosaccharide or a combination thereof; and
about 5 mg/100 Kcal to about 75 mg/100 Kcal of docosahexaenoic acid; and
b) administering breast milk from the lactating female to the infant.

10. The method of claim 9 , wherein the nutritional supplement further comprises up to about 7 g/100 Kcal of a fat or lipid source; and up to about 5 g/100 Kcal of a protein source.

11. The method of claim 9 , wherein polydextrose and galactooligosaccharide comprise at least about 20% of the prebiotic composition.

12. The method of claim 9 , wherein the nutritional supplement further comprises Lactobacillus rhamnosus GG.

13. The method of claim 9 , wherein the nutritional supplement further comprises arachidonic acid, wherein arachidonic acid and docosahexaenoic acid are present in a weight ratio ranging from about 1:3 to 9:1.

14. The method of claim 9 , wherein the nutritional supplement further comprises human milk oligosaccharides.

15. The method of claim 9 , wherein the phosphatidylethanolamine and sphingomyelin are provided by a milk fat globular membrane-enriched ingredient.

16. The method of claim 9 , wherein the nutritional supplement further comprises a carbohydrate source comprising lactose.

Assignees

• Mead Johnson Nutrition Co

Inventors

• Kuang Chenzhong
• Hondmann Dirk
• Mcmahon Robert J
• Xiao Yan

Classifications

• A23L33/10

  using additives (addition of substantially indigestible substances A23L33/21) · CPC title

• A23L33/00

  Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof · CPC title

• A23V2250/1862

  Arachidonic acid · CPC title

• A23L33/12

  Fatty acids or derivatives thereof · CPC title

• A23L33/40

  Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula · CPC title