Oral care product for sensitive enamel care

Patent metadata

Field	Value
Publication number	US-10610707-B2
Application number	US-201113574205-A
Country	US
Kind code	B2
Filing date	Jan 28, 2011
Priority date	Jan 29, 2010
Publication date	Apr 7, 2020
Grant date	Apr 7, 2020

Abstract

Disclosed are anti-erosion oral care formulations and methods that provide erosion protection while maintaining adequate cleaning performance. The anti-erosion oral care formulations include a copolymer of a methylvinyl ether and a maleic anhydride and a metal compound or salt that becomes more soluble at acidic pH.

First claim

What is claimed is:

1. An oral care composition comprising:
(a) an orally acceptable vehicle;
(b) 0.05-3% by weight of a mucoadhesive polymer, wherein said mucoadhesive polymer is a copolymer of a methylvinyl ether and a maleic anhydride;
(c) a calcium compound or salt that becomes more soluble at acidic pH in an effective amount to provide protection against erosion of tooth enamel; and
(d) 5-40% by weight of a siliceous abrasive,
wherein the calcium compound or salt is precipitated calcium carbonate having a pH of about 8.75, which, when solubilized, reacts with the tooth enamel to shift the solubility equilibrium away from dissolution of the tooth enamel, wherein the mucoadhesive polymer confines some of the calcium compound or salt at the surface of a tooth, wherein the calcium compound or salt has a longer residence time in proximity to the tooth, where the residence time is longer compared to a composition which does not contain the mucoadhesive polymer, and
wherein the composition does not include triclosan; and
wherein the composition has less enamel loss, when measured against a reference standard, upon challenge in an aqueous solution with about 5% by wt. of citric acid.

2. A method of reducing acid based erosion of teeth comprising:
1) providing an effective amount of the oral care composition of claim 1 ; and
2) delivering the composition to the oral cavity of a subject, wherein delivering the composition deposits a layer of the copolymer of a methylvinyl ether and a maleic anhydride and metal compound or salt on tooth enamel.

3. The oral care composition of claim 1 , wherein the composition comprises more precipitated calcium carbonate than siliceous abrasive.

4. The oral care composition of claim 1 , wherein the composition is in the form of a single homogeneous phase.

Assignees

• Pilch Shira
• Masters James Gerald
• Lu Zhi
• Miksa Davide
• Colgate Palmolive Co

Inventors

• Pilch Shira
• Masters James Gerald
• Lu Zhi
• Miksa Davide

Classifications

• A61K8/8164

  Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride) · CPC title

• A61K8/27

  Zinc; Compounds thereof · CPC title

• A61Q11/00 Primary

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K8/19 Primary

  containing inorganic ingredients · CPC title

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title