Ceramide production-accelerating agent

Patent metadata

Field	Value
Publication number	US-10610561-B2
Application number	US-201514600701-A
Country	US
Kind code	B2
Filing date	Jan 20, 2015
Priority date	Aug 18, 2008
Publication date	Apr 7, 2020
Grant date	Apr 7, 2020

Abstract

The present invention provides a pharmaceutical composition or a cosmetic product which can accelerate production of ceramide in cells. The ceramide production-accelerating agent contains a plant selected from the group consisting of Radix Heraclei Scabridi, Rhizoma Dioscoreae, Radix Rehmanniae, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Pseudobulbus Bletillae, Radix Polygoni Multiflori, Radix Platycodi, and Herba Leonuri, or an extract thereof as an active ingredient. Further, the present invention provides a moisturizing agent containing a plant selected from the group consisting of Herba Leonuri and Rhizoma Dioscoreae, or an extract thereof as an active ingredient.

First claim

What is claimed is:

1. A method for accelerating ceramide production in a normal human keratinocyte comprising
administering an extract of a plant selected from the group consisting of Angelicae Dahuricae Radix, Atractylodis Rhizoma, Bletilla Tuber, Polygoni Multiflori Radix, Platycodi Radix, Leonuri herba , and Dioscoreae Rhizoma , as an active ingredient to the normal human keratinocyte,
wherein the extract is a petroleum ether extract prepared by using petroleum ether as an extraction solvent, and
wherein, as a result of the administering, ceramide production in the keratinocyte is accelerated.

2. The method according to claim 1 , wherein the plant is Leonuri herba.

3. A method of moisturizing skin, comprising
administering an extract of the plant Leonuri herba , as an active ingredient to the skin,
wherein the extract is a petroleum ether extract prepared by using petroleum ether as an extraction solvent, and
wherein, as a result of the administering, the skin is moisturized.

4. The method according to claim 1 , wherein 0.001 to 1000 mg per day of the extract is administered.

5. The method according to claim 3 , wherein 0.001 to 1000 mg per day of the extract is administered.

6. A method for accelerating ceramide production in a normal human keratinocyte, said method comprising
administering, to the keratinocyte, 0.001 to 1000 mg per day of a Leonuri herba extract,
wherein said extract is administered as an external preparation for skin that comprises 0.001% to 10% by mass of said extract (dry solid content) as an active ingredient, and
wherein said extract is a petroleum ether extract prepared by using petroleum ether as an extraction solvent, and
wherein, as a result of the administering, ceramide production in the keratinocyte is accelerated.

7. A method for moisturizing skin, said method comprising
administering, to the skin, 0.001 to 1000 mg per day of a Leonuri herba extract,
wherein said extract is administered as an external preparation for skin that comprises 0.001% to 10% by mass (dry solid content) of said extract as an active ingredient, and
wherein said extract is a petroleum ether extract prepared by using petroleum ether as an extraction solvent, and
wherein, as a result of the administering, the skin is moisturized.

8. The method of claim 1 , wherein the extract is administered as an external preparation for skin.

9. The method of claim 3 , wherein the extract is administered as an external preparation for skin.

Assignees

• Zhongshan Hospital Of Fudan Univ
• Kao Corp

Inventors

• Qin Wan Zhang
• Yang Chun Xin
• Kong Fan Qi
• Nojiri Hiroshi
• Ito Shotaro

Classifications

• A61K36/484

  Glycyrrhiza (licorice) · CPC title

• A61K8/9794

  Liliopsida [monocotyledons] · CPC title

• A61P17/16

  Emollients or protectives, e.g. against radiation · CPC title

• A61P19/00

  Drugs for skeletal disorders · CPC title

• A61K36/284

  Atractylodes · CPC title