Process for producing Gallium-68 through the irradiation of a solution target

Patent metadata

Field	Value
Publication number	US-10600528-B2
Application number	US-201815998846-A
Country	US
Kind code	B2
Filing date	Aug 17, 2018
Priority date	Jun 5, 2015
Publication date	Mar 24, 2020
Grant date	Mar 24, 2020

Abstract

The present disclosure relates to a process for purifying and concentrating 68 Ga isotope produced by irradiation with an accelerated particle beam of a 68 Zn target in solution. The process according to the present disclosure allows for the production of pure and concentrated 68 Ga isotope in hydrochloric acid solution. The present disclosure also relates to a disposable cassette for performing the steps of purification and concentration of the process.

First claim

What is claimed is:

1. A process for producing and purifying 68 Gallium radioisotope, the process comprising:
irradiating a target containing a target solution comprising zinc using an accelerated particle beam;
diluting the irradiated target solution with water;
feeding the diluted target solution into a strong cation exchanger;
washing the strong cation exchanger;
eluting zinc isotopes from the strong cation exchanger with a zinc elution solution including acetone;
washing the strong cation exchanger;
eluting 68 Gallium isotope from the strong cation exchanger with hydrochloric acid solution to obtain an eluted solution;
feeding the eluted solution into a strong anion exchanger,
washing the strong anion exchanger; and
eluting 68 Gallium isotope from the strong anion exchanger with hydrochloric acid solution to obtain a final solution
wherein the irradiated target solution is diluted between 5 and 15 volume times with water.

2. The process according to claim 1 , wherein the irradiated target solution is diluted from 10 to 15 volume times with water.

3. The process according to claim 1 , further comprising:
complementing the eluted solution with another hydrochloric acid solution to obtain a complemented solution, wherein the complementing is performed before feeding the eluted solution into the strong anion exchanger.

4. The process according to claim 3 , wherein the complemented solution includes a molarity in hydrochloric acid between 7 M and 10 M.

5. The process according to claim 1 , wherein the accelerated particle beam is a proton beam produced by a cyclotron.

6. The process according to claim 1 , wherein the strong cation exchanger is preconditioned with water before feeding the diluted target solution into the strong cation exchanger.

7. The process according to claim 1 , wherein eluting zinc isotopes from the strong cation exchanger is performed with a solution of acetone 80%/HBr 0.5 M.

8. The process according to claim 1 , wherein the final solution includes 68 Gallium in a hydrochloric acid solution of molarity between 0.08 M and 1.2 M.

9. The process according to claim 1 , wherein the strong anion exchanger is preconditioned with hydrochloric acid solution before feeding the eluted solution into the strong anion exchanger.

10. The process according to claim 1 , wherein the target solution comprising zinc further includes a zinc salt diluted in nitric acid or hydrochloric acid, wherein the zinc salt is selected from the group consisting of zinc nitrate, zinc chloride, zinc chlorate, zinc bromide, zinc iodide or zinc sulfate.

11. The process according to claim 1 further comprising:
reacting the final solution including 68 Gallium isotope with a peptide dissolved in a buffer at a pH between 3.5 and 3.9 to obtain a radiolabelled-peptide;
cooling the radiolabelled-peptide to a temperature below 40° C.; and
purifying the radiolabelled-peptide on a C18 column.

12. The process according to claim 2 , further comprising:
complementing the eluted solution with another hydrochloric acid solution to obtain a complemented solution, wherein the complementing is performed before feeding the eluted solution into the strong anion exchanger.

13. The process according to claim 2 , wherein the final solution includes 68 Gallium in a hydrochloric acid solution of molarity between 0.08 M and 1.2 M.

14. The process according to claim 3 , wherein the strong cation exchanger is preconditioned with water before feeding the diluted target solution into the strong cation exchanger.

15. The process according to claim 3 further comprising:
reacting the final solution including 68 Gallium isotope with a peptide dissolved in a buffer at a pH between 3.5 and 3.9 to obtain a radiolabelled-peptide;
cooling the radiolabelled-peptide to a temperature below 40° C.; and
purifying the radiolabelled-peptide on a C18 column.

16. The process according to claim 4 , wherein the strong cation exchanger is preconditioned with water before feeding the diluted target solution into the strong cation exchanger.

17. The process according to claim 4 , wherein the accelerated particle beam is a proton beam produced by a cyclotron.

18. The process according to claim 6 further comprising:
reacting the final solution including 68 Gallium isotope with a peptide dissolved in a buffer at a pH between 3.5 and 3.9 to obtain a radiolabelled-peptide;
cooling the radiolabelled-peptide to a temperature below 40° C.; and
purifying the radiolabelled-peptide on a C18 column.

19. The process according to claim 7 , wherein the strong anion exchanger is preconditioned with hydrochloric acid solution before feeding the eluted solution into the strong anion exchanger.

20. The process according to claim 9 , wherein the target solution comprising zinc further includes a zinc salt diluted in nitric acid or hydrochloric acid, wherein the zinc salt is selected from the group consisting of zinc nitrate, zinc chloride, zinc chlorate, zinc bromide, zinc iodide or zinc sulfate.

Assignees

• Ion Beam Appl Sa

Inventors

• Abrunhosa Antero
• Alves Vitor
• Alves Francisco

Classifications

• G21G2001/0021

  Gallium · CPC title

• B01J39/18

  Macromolecular compounds (B01J39/17 takes precedence) · CPC title

• B01J47/00

  Ion-exchange processes in general; Apparatus therefor (ion-exchange chromatography processes or apparatus B01D15/08) · CPC title

• B01J39/05

  in the strongly acidic form · CPC title

• C07B2200/05

  Isotopically modified compounds, e.g. labelled · CPC title