Selective capture and release of rare mammalian cells using photodegradable hydrogels in a microfluidic platform
US-2016153999-A1 · Jun 2, 2016 · US
Photodegradable sample collection system and method
US10598577B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10598577-B2 |
| Application number | US-201715639511-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 30, 2017 |
| Priority date | Jun 30, 2017 |
| Publication date | Mar 24, 2020 |
| Grant date | Mar 24, 2020 |
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- Title
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Abstract
Official abstract text for this publication.
A method includes providing a biological sample, providing a sample collection device, wherein the sample collection device includes a sample binding surface including a photodegradable polymer configured to bind the biological sample, contacting the biological sample with the sample binding surface of the sample collection device, and irradiating the sample binding surface and the bound biological sample using light emitted from a light source to initiate degradation of the photodegradable polymer of the sample binding surface to cause release of the biological sample.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method, comprising: providing a biological sample; providing a sample collection device, wherein the sample collection device comprises a sample binding surface comprising a photodegradable polymer configured to bind the biological sample, wherein the sample binding surface or a coating of the sample collection device comprises fibers comprising the photodegradable polymer wherein the fibers are between 1 nanometer and 20 micrometers in thickness; contacting the biological sample with the sample binding surface of the sample collection device; irradiating the sample binding surface and the bound biological sample using light emitted from a light source to initiate degradation of the photodegradable polymer of the sample binding surface to cause release of the biological sample, wherein the light comprises light of a wavelength between 300 nanometers and 700 nanometers. 2. The method of claim 1 , wherein the photodegradable polymer comprises one or more hydrophobic polymers. 3. The method of claim 1 , wherein the photodegradable polymer is water insoluble in polymer form. 4. The method of claim 1 , wherein the degradation of the photodegradable polymer comprises cleaving one or more photocleavable moieties of the photodegradable polymer to break the photodegradable polymer into a plurality of polymers, monomers, oligomers, or a combination thereof, wherein the plurality of polymers, monomers, oligomers, or a combination thereof is water soluble. 5. The method of claim 4 , further comprising: contacting the sample binding surface and the bound biological sample with a solution before initiating the degradation, wherein the plurality of polymers, monomers, oligomers, or a combination thereof are released into the solution; and isolating the biological sample from the solution. 6. The method of claim 1 , wherein the sample binding surface or a coating of the sample collection device comprises fibers comprising the photodegradable polymer, wherein the fibers are created by electrospinning. 7. The method of claim 1 , wherein the light is of a wavelength between 350 nm and 380 nm. 8. The method of claim 1 , wherein the sample collection device comprises one of a swab, a pad, a brush, or a piece of paper.
Assignees
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Classifications
by ultraviolet or visible light · CPC title
Processes for the isolation, preparation or purification of DNA or RNA (chemical preparation of DNA or RNA C07H21/00; preparation of non-structural polynucleotides from microorganisms or with enzymes C12P19/34) · CPC title
by means of a solid support carrier, e.g. particles, polymers · CPC title
Apparatus specially adapted for solid-phase testing · CPC title
for biomedical use · CPC title
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- What does patent US10598577B2 cover?
- A method includes providing a biological sample, providing a sample collection device, wherein the sample collection device includes a sample binding surface including a photodegradable polymer configured to bind the biological sample, contacting the biological sample with the sample binding surface of the sample collection device, and irradiating the sample binding surface and the bound biolog…
- Who is the assignee on this patent?
- Gen Electric, Univ Akron
- What technology area does this patent fall under?
- Primary CPC classification G01N1/44. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Mar 24 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).