Compounds, compositions, and methods for the treatment of inflammatory, degenerative, and neurodegenerative diseases
US-2024409487-A1 · Dec 12, 2024 · US
US10596138B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10596138-B2 |
| Application number | US-201615760471-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 13, 2016 |
| Priority date | Sep 16, 2015 |
| Publication date | Mar 24, 2020 |
| Grant date | Mar 24, 2020 |
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Liquid nutritional compositions that include functional ingredients such as beta-hydroxy-beta-methylbutyrate, docosahexaenoic acid, and lutein are disclosed. The nutritional compositions are useful to promote at least one of physical performance (e.g., body composition, muscle mass, muscle strength) and cognitive function (e.g., focus, attention, alertness, executive function) in an individual. The functional ingredients are incorporated into the nutritional composition in such a way that they do not adversely affect the desirable properties of the nutritional composition such as, for example, nutritional value, stability, solubility, taste, and mouthfeel.
Opening claim text (preview).
What is claimed is: 1. A liquid nutritional composition comprising, per 237 ml serving: beta-hydroxy-beta-methylbutyrate (HMB) in an amount of 0.25 g to 3 g; fat comprising docosahexaenoic acid (DHA), wherein the DHA is in an amount of 32 mg to 2500 mg; lutein in an amount of 0.3 mg to 35 mg; and 10 g to 20 g of protein; wherein a weight ratio of the fat to the protein is from 0.55 to less than 0.8; and wherein the liquid nutritional composition comprises an oil-in-water emulsion. 2. The liquid nutritional composition of claim 1 , wherein the protein comprises milk protein isolate, milk protein concentrate, casein protein isolate, extensively hydrolyzed casein, sodium or calcium caseinate, whey protein, whey protein concentrate, whey protein isolate, whey protein hydrosylate, whole cow milk, partially or completely defatted milk, soy protein isolate, soy protein concentrate, or a combination thereof. 3. The liquid nutritional composition of claim 1 , wherein the fat further comprises coconut oil, fractionated coconut oil, soy oil, corn oil, olive oil, safflower oil, high oleic safflower oil, MCT (medium chain triglycerides) oil, sunflower oil, high oleic sunflower oil, palm oil, palm kernel oil, palm olein, canola oil, high oleic canola oil, marine oil, fish oil, fungal oil, algae oil, cottonseed oil, or a combination thereof. 4. The liquid nutritional composition of claim 1 , further comprising copper, wherein the copper is present in an amount of less than 0.0004 mg per mL of the liquid nutritional composition. 5. The liquid nutritional composition of claim 4 , wherein the copper is present in an amount of less than 0.0002 mg per mL of the liquid nutritional composition. 6. The liquid nutritional composition of claim 1 , further comprising iron, wherein the iron is present in an amount of less than 0.004 mg per mL of the liquid nutritional composition. 7. The liquid nutritional composition of claim 6 , wherein the iron is present in an amount of less than 0.002 mg per mL of the liquid nutritional composition. 8. The liquid nutritional composition of claim 1 , further comprising zinc, wherein the zinc is present in an amount of less than 0.025 mg/mL. 9. The liquid nutritional composition of claim 8 , wherein the zinc is present in an amount of less than 0.019 mg/m L. 10. The liquid nutritional composition of claim 1 , wherein the liquid nutritional composition has a caloric density of less than 1.4 kcal/mL. 11. The liquid nutritional composition of claim 1 , wherein the liquid nutritional composition has a caloric density of from 1.05 to 1.4 kcal/m L. 12. The liquid nutritional composition of claim 1 , further comprising carbohydrate in an amount of less than 60 g in the serving of the liquid nutritional composition. 13. A liquid nutritional composition comprising, per 237 ml serving: beta-hydroxy beta-methylbutyrate (HMB) in an amount of 0.25 g to 3 g; fat comprising docosahexaenoic acid (DHA), wherein the DHA is in an amount of 32 mg to 2500 mg; lutein in an amount of 0.3 mg to 20 mg; and 10 g to 20 g of protein; wherein a weight ratio of the fat to the protein is from 0.55 to less than 0.8; and wherein the liquid nutritional composition comprises an oil-in-water emulsion. 14. The liquid nutritional composition of claim 13 , wherein the HMB is present in an amount of 1 g to 3 g in the serving of the liquid nutritional composition. 15. The liquid nutritional composition of claim 13 , wherein the HMB is present in an amount of about 1.5 g in the serving of the liquid nutritional composition. 16. The liquid nutritional composition of claim 13 , wherein the HMB is calcium HMB. 17. The liquid nutritional composition of claim 13 , wherein the DHA is present in an amount of 50 mg to 1000 mg in the serving of the liquid nutritional composition. 18. The liquid nutritional composition of claim 13 , wherein the DHA is present in an amount of about 125 mg in the serving of the liquid nutritional composition. 19. The liquid nutritional composition of claim 13 , wherein the lutein is present in an amount of 0.3 mg to 10 mg in the serving of the liquid nutritional composition. 20. The liquid nutritional composition of claim 13 , wherein the lutein is present in an amount of about 6 mg in the serving of the liquid nutritional composition. 21. A liquid nutritional composition comprising, per 237 ml serving: beta-hydroxy-beta-methylbutyrate (HMB) in an amount of 1 g to 2.5 g; fat comprising docosahexaenoic acid (DHA), wherein the DHA is in an amount of 50 mg to 150 mg; lutein in an amount of 5 mg to 8 mg; 10 g to 15 g of protein; and 6 g to 9 g of the fat; and wherein a weight ratio of the fat to the protein is from 0.55 to less than 0.8; and wherein the liquid nutritional composition comprises an oil-in-water emulsion. 22. The liquid nutritional composition of claim 1 , wherein the weight ratio of the fat to the protein is from 0.55 to less than 0.7.
Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula · CPC title
Fatty acids or derivatives thereof · CPC title
using additives (addition of substantially indigestible substances A23L33/21) · CPC title
having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557) · CPC title
Zinc; Compounds thereof · CPC title
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