Hyperpolarized noble gas production systems with nanocluster suppression, detection and/or filtering and related methods and devices

Patent metadata

Field	Value
Publication number	US-10583205-B2
Application number	US-201916653082-A
Country	US
Kind code	B2
Filing date	Oct 15, 2019
Priority date	Feb 21, 2014
Publication date	Mar 10, 2020
Grant date	Mar 10, 2020

Abstract

Systems, methods and related devices used to produce and collect polarized noble gas to inhibit, suppress, detect or filter alkali metal nanoclusters to preserve or increase a polarization level thereof. The systems can include a pre-sat chamber that has an Area Ratio between 20 and 500.

First claim

That which is claimed is:

1. A flow-through optical spin exchange hyperpolarized gas production system for producing hyperpolarized gas comprising:
a pre-saturation chamber comprising an Area Ratio (AR) of between 20 and 500, wherein the pre-saturation chamber comprises alkali metal therein;
a heat source in communication with the pre-saturation chamber configured to heat the pre-saturation chamber to between 140 Celsius and 300 Celsius;
a flow-through optical pumping cell in fluid communication with the pre-saturation chamber;
a gas mixture comprising 129 Xe gas in the optical pumping cell; and
a heat source in communication with the optical pumping cell, wherein the heat source is configured to heat the optical pumping cell to a temperature that is less than the pre-saturation chamber,
wherein the system hyperpolarizes the 129 Xe gas in the optical pumping cell and provides at least one bolus amount of the hyperpolarized 129 Xe gas for inhalation delivery to a patient.

2. The system of claim 1 , further comprising an accumulator in fluid communication with the optical pumping and located downstream of the optical pumping cell, wherein the accumulator collects the at least one bolus amount of the hyperpolarized 129 Xe gas.

3. The system of claim 2 , further comprising a bag that is releasably coupled to the accumulator and that holds the at least one bolus amount of the hyperpolarized gas for inhalation delivery to the patient.

4. The system of claim 3 , wherein the at least one bolus amount of hyperpolarized 129 Xe gas in the bag has sufficient hyperpolarization level when dispensed to the patient in an MRI scanner to obtain MR spectroscopy data and/or MRI image data of at least one of pulmonary ventilation or gas exchange in one or more lungs of the patient.

5. The system of claim 1 , wherein the AR of the pre-saturation chamber is between 20 and 200.

6. The system of claim 1 , wherein a new and/or previously unused pre-saturation chamber comprises rubidium (Rb) in an amount between 0.5 and 5 grams.

7. The system of claim 1 , wherein the pre-saturation chamber is a first pre-saturation chamber and has axially spaced apart first and second end portions that releasably and sealably engage a flow manifold that resides upstream of the optical pumping cell, wherein the first and second end portions are detachable from the flow manifold of the hyperpolarized gas production system, wherein the flow manifold releasably and sealably engages first and second end portions of a second pre-saturation chamber having a common size and shape as the first pre-saturation chamber, wherein the second pre-saturation chamber is filled with alkali metal to thereby allow for a plurality of pre-saturation chambers to be used with the same optical pumping cell over production cycles to provide at least one bolus amount of the hyperpolarized 129 Xe gas.

8. The system of claim 1 , further comprising a pressurized flow manifold that resides upstream of the optical pumping cell and maintains a gas flow path into the optical pumping cell at a defined pressure, wherein the pre-saturation chamber is a detachable pre-saturation chamber that, in operation, is interchangeably, sealably attached to the pressurized flow manifold with at least one quick connect and/or valve.

9. The system of claim 1 , further comprising a voltage source that is configured to generate an electrical field between about 2 kV/cm to about 20 kV/cm in or about the optical pumping cell, wherein the electrical field is configured to attract charged nanoclusters.

10. The system of claim 1 , further comprising:
a control circuit in communication with the optical pumping cell;
a probe laser configured to project an off-resonance probe beam across the optical pumping cell; and
a detector in communication with the probe laser and control circuit, positioned across from the probe laser on an opposing side of the optical pumping cell, wherein the control circuit is configured to identify attenuation of a signal from the probe beam that is associated with production of nanoclusters in the gas flow stream in the optical pumping cell.

11. The system of claim 1 , wherein the pre-saturation chamber is external to the optical pumping cell and is upstream of an inlet port of the optical pumping cell.

12. The system of claim 8 , wherein the pre-saturation chamber comprises threads, a valve and/or a nozzle and is detachably, sealably attached to the flow manifold.

13. The system of claim 1 , further comprising an accumulator in fluid communication with and downstream of the optical pumping cell, wherein, in operation, the hyperpolarized 129 Xe gas is exposed to temperatures below its freezing point and collected as a frozen product at the accumulator.

14. The system of claim 13 , further comprising a magnetic yoke of permanent magnets surrounding a portion of a cold finger of the accumulator.

15. The system of claim 1 , wherein the system further comprises a probe laser positioned along one long side of the optical pumping cell, wherein the probe laser directs a probe beam across the optical cell in a direction that is orthogonal to a direction of a spin-exchange optical pumping laser beam.

16. The system of claim 15 , further comprising regional heat sources for defining an optical window on each side of the optical pumping cell for the probe laser to project across without attenuation due to alkali metal deposited onto an inner surface of the cell under the optical window.

17. A flow-through optical spin exchange hyperpolarized gas production system for producing hyperpolarized gas comprising:
a pre-saturation chamber comprising an Area Ratio (AR) of between 20 and 500, wherein the pre-saturation chamber comprises alkali metal therein;
a heat source in communication with the pre-saturation chamber configured to heat the pre-saturation chamber to between 140 Celsius and 300 Celsius;
a flow-through optical pumping cell in fluid communication with the pre-saturation chamber;
a gas mixture comprising 129 Xe gas in the optical pumping cell;
a heat source in communication with the optical pumping cell, wherein the heat source is configured to heat the optical pumping cell to a temperature that is less than the pre-saturation chamber;
a control circuit in communication with the optical pumping cell;
a probe laser configured to project an off-resonance probe beam across the optical pumping cell, wherein the probe laser has a wavelength that generates a blue laser beam; and
a detector in communication with the probe laser and control circuit, positioned across from the probe laser on an opposing side of the optical pumping cell, wherein attenuation of a signal from the probe beam is associated with production of nanoclusters in the gas flow stream in the optical pumping cell,
wherein the system hyperpolarizes the 129 Xe gas in the optical pumping cell and provides at least one bolus amount of the hyperpolarized 129 Xe gas for inhalation delivery to a patient.

18. The system of claim 17 , wherein the probe laser has a wavelength of about 450 nm.

19. The system of claim 17 , wherein the pre-saturation chamber is external to the optical pumping cell and is upstream of an inlet port of the optical pumping cell.

20. The system of claim 17 , wherein the at least one bolus amount of hyperpolarized 129 Xe gas has sufficient hyperpolarization level when dispensed to the patient in an MRI scanner to obtain MR spectroscopy data and/or MRI image data of at least one of pulmonary ventilatio

Assignees

• Univ Duke

Inventors

• Freeman Matthew S
• Driehuys Bastiaan

Classifications

• G01R33/282

  Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent · CPC title

• C01B23/00

  Noble gases; Compounds thereof (liquefying F25J {; noble gases obtained by rectification F25J3/028}) · CPC title

• C01B23/0036

  Physical processing only · CPC title

• A61K49/18 Primary

  characterised by a special physical form, e.g. emulsions, microcapsules, liposomes · CPC title

• A61K49/06 Primary

  Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations · CPC title