Compositions useful in the prevention and/or treatment of osteoarticular inflammation and pain and cartilage damage

Patent metadata

Field	Value
Publication number	US-10583162-B2
Application number	US-201716313202-A
Country	US
Kind code	B2
Filing date	Jun 28, 2017
Priority date	Jun 29, 2016
Publication date	Mar 10, 2020
Grant date	Mar 10, 2020

Abstract

The present invention relates to compositions comprising: a) a Vitis vinifera extract in free form or in the form of a complex with phospholipids, or a Punica granatum extract; and b) a lipophilic extract of Zingiber officinale; and c) a lipophilic extract obtained from plants containing polyunsaturated fatty acid isobutylamides selected from the group consisting of Echinacea spp. extract or Zanthoxylum spp. extract or Acmella oleracea (or Spilanthes oleracea) extract; and d) an unsaponifiable fraction of olive oil and/or corn oil; or e) N-acetyl glucosamine; or f) diacerein; and their use in the prevention and/or treatment of osteoarticular inflammation and pain, and cartilage damage.

First claim

The invention claimed is:

1. A composition comprising:
a) an extract of Vitis vinifera in free form or in the form of a complex with phospholipids, or an extract of Punica granatum in amounts ranging from 50 to 1000 mg;
b) a lipophilic extract of Zingiber officinale in amounts ranging from 10 to 80 mg;
c) a lipophilic extract of Zanthoxylum spp. in amounts ranging from 1 to 50 mg or, alternatively, a lipophilic extract of Echinacea spp. or of Acmella oleracea in amounts ranging from 5 to 50 mg;
and
d) an unsaponifiable fraction of olive oil and/or corn oil in amounts ranging from 50 to 500 mg; or
e) N-acetylglucosamine in amounts ranging from 50 to 500 mg; or
f) diacerein in amounts ranging from 20 to 200 mg.

2. The composition according to claim 1 , comprising:
a) an extract of Vitis vinifera seeds in free form or in the form of a complex with phospholipids, or an extract of Punica granatum in amounts ranging from 50 to 1000 mg; and
b) a lipophilic extract of Zingiber officinale in amounts ranging from 10 to 80 mg; and
c) a lipophilic extract of Zanthoxylum spp. in amounts ranging from 1 to 50 mg or, alternatively, a lipophilic extract of Echinacea spp. or of Acmella oleracea in amounts ranging from 5 to 50 mg; and
d) an unsaponifiable fraction of olive oil in amounts ranging from 50 to 500 mg.

3. The composition according to claim 1 , for oral administration comprising per dosage unit:
a) an extract of Vitis vinifera in free form or in the form of a complex with phospholipids, or an extract of Punica granatum , in amounts ranging from 50 to 1000 mg;
b) a lipophilic extract of Zingiber officinale in amounts ranging from 10 to 80 mg;
c) a lipophilic extract of Zanthoxylum spp. in amounts ranging from 1 to 50 mg or, alternatively, a lipophilic extract of Echinacea spp. or of Acmella oleracea in amounts ranging from 5 to 50 mg;
d) an unsaponifiable fraction of olive oil in amounts ranging from 50 to 500 mg.

4. The composition according to claim 3 , comprising:
a) an extract of Vitis vinifera in free form or in the form of a complex with phospholipids, or an extract of Punica granatum , in the amount of 200 mg;
b) a lipophilic extract of Zingiber officinale in the amount of 50 mg;
c) a lipophilic extract of Zanthoxylum spp. in the amount of 20 mg or, alternatively, a lipophilic extract of Echinacea spp. or of Acmella oleracea in the amount of 10 mg;
d) an unsaponifiable fraction of olive oil in the amount of 150 mg.

5. The composition according to claim 1 comprising:
a) an extract of Vitis vinifera in free form or in the form of a complex with phospholipids, or an extract of Punica granatum in amounts ranging from 50 to 1000 mg;
b) a lipophilic extract of Zingiber officinale in amounts ranging from 10 to 80 mg; and
c) a lipophilic extract obtained from plants containing polyunsaturated fatty acid isobutylamides selected from the group consisting of Echinacea spp. extract, Zanthoxylum spp. extract and Acmella oleracea extract in amounts ranging from 5 to 50 mg;
d) N-acetylglucosamine in amounts ranging from 50 to 500 mg; or
e) diacerein in amounts ranging from 20 to 200 mg.

6. The composition according to claim 5 comprising
a) an extract of Vitis Vinifera in a free form or in the form of a complex with phospholipids, or an extract of Punica granatum in the amount of 200 mg;
b) a lipophilic extract of Zingiber officinale in the amount of 50 mg;
c) a lipophilic extract of Zanthoxylum spp. in the amount of 20 mg or, alternatively, a lipophilic extract of Echinacea spp. or of Acmella oleracea in the amount of 10 mg;
d) N-acetylglucosamine in the amount of 150 mg; or
e) diacerein in the amount of 50 mg.

7. The composition according to claim 5 , comprising:
a) an extract of Vitis vinifera complexed with phospholipids in the amount of 200 mg;
b) a lipophilic extract of Zingiber officinale , containing 30% w/w of gingerols and shogaols, in the amount of 50 mg;
c) a lipophilic extract of Zanthoxylum spp. in the amount of 10 mg;
d) an unsaponifiable fraction of olive oil in the amount of 100 mg; or
e) N-acetylglucosamine in the amount of 150 mg; or
f) diacerein in the amount of 50 mg.

8. The composition according to claim 1 , for topical administration comprising:
a) an extract of Vitis vinifera complexed with phospholipids in amounts ranging from 0.1 to 2.5% w/w;
b) a lipophilic extract of Zingiber officinale in amounts ranging from 0.1 to 1% w/w;
c) a lipophilic extract of Zanthoxylum spp. in amounts ranging from 0.1 to 1% w/w;
d) an unsaponifiable fraction of olive oil in amounts ranging from 0.1 to 1% w/w.

9. The composition according to claim 7 , comprising:
a) the extract of Vitis vinifera complexed with phospholipids in the amount of 1% w/w;
b) the lipophilic extract of Zingiber officinale in the amount of 0.5% w/w;
c) the lipophilic extract of Zanthoxylum spp. in the amount of 0.5% w/w;
d) the unsaponifiable fraction of olive oil in the amount of 0.5% w/w.

10. The composition according to claim 1 , wherein Punica granatum extract is characterised by a 40% w/w content of punicalagins.

11. The composition according to claim 1 , wherein the lipophilic extract of Zingiber officinale is characterised by a 30% w/w content of gingerols and shogaols.

12. The composition according to claim 1 , wherein the unsaponifiable fraction of olive oil is characterized by a content in terpenes and polyalcohols ranging from 40 to 90% w/w.

13. The composition according to claim 1 for use in the prevention and/or treatment of inflammation and pain.

14. The composition for use according to claim 13 , wherein said inflammation and said pain comprise osteoarticular inflammation, pain, and cartilage damage.

15. The composition for use according to claim 13 , wherein said pain is systematic pain or peripheral pain in small and large joints, said joints comprising knee and femoral sockets.

16. The composition for use according to claim 15 , wherein said peripheral pain is due to diabetic neuropathy, neuropathy induced by chemotherapy, muscle pains and inflammatory states comprising cutaneous inflammations.

17. A composition comprising:
a) an extract of Vitis vinifera in free form or in the form of a complex with phospholipids, or an extract of Punica granatum in amounts ranging from 200 to 250 mg;
b) a lipophilic extract of Zingiber officinale in the amount of 50 mg;
c) a lipophilic extract obtained from plants containing polyunsaturated fatty acid isobutylamides selected from the group consisting of Echinacea spp. extract, Zanthoxylum spp. extract and Acmella oleracea extract in amounts ranging from 15 to 20 mg;
d) an unsaponifiable fraction of olive oil and/or corn oil in the amount of 150 mg; or
e) N-acetylglucosamine in the amount of 150 mg; or
f) diacerein in the amount of 50 mg.

Assignees

• Indena Spa

Inventors

• Bombardelli Ezio

Classifications

• A61K36/63

  Oleaceae (Olive family), e.g. jasmine, lilac or ash tree · CPC title

• A61K36/899

  Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane · CPC title

• A61K31/194

  having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid · CPC title

• A61K9/4875

  Compounds of unknown constitution, e.g. material from plants or animals (oils, fats, waxes, shellac A61K9/4858) · CPC title

• A61K31/16 Primary

  Amides, e.g. hydroxamic acids · CPC title