Methods and therapeutic combinations for treating tumors
US-9980956-B2 · May 29, 2018 · US
Methods and therapeutic combinations for treating tumors
US10583134B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10583134-B2 |
| Application number | US-201815964604-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 27, 2018 |
| Priority date | Aug 1, 2014 |
| Publication date | Mar 10, 2020 |
| Grant date | Mar 10, 2020 |
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- Title
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Abstract
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Methods and therapeutic combinations useful for increasing cell-mediated anti-tumor responses are described. The methods include administering to a subject a therapeutically effective amount of an Immune Response Modifier Compound and a therapeutically effective amount of one or more immune checkpoint inhibitor compounds.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of treating a tumor in a subject in need thereof, comprising administering a therapeutically effective amount of a PD-L1 antibody to the subject; and administering a therapeutically effective amount of an IRM compound to the subject; wherein the IRM compound is N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide, or a pharmaceutically acceptable salt thereof. 2. A method of treating a tumor in a subject in need thereof, comprising administering a therapeutically effective amount of a CTLA-4 antibody to the subject; and administering a therapeutically effective amount of an IRM compound to the subject; wherein the IRM compound is N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide, or a pharmaceutically acceptable salt thereof. 3. A method of treating a tumor in a subject in need thereof, comprising administering a therapeutically effective amount of a PD-L1 antibody to the subject; and administering a therapeutically effective amount of a CTLA-4 antibody to the subject; and administering a therapeutically effective amount of an IRM compound to the subject; wherein the IRM compound is N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide, or a pharmaceutically acceptable salt thereof. 4. The method of any one of claims 1 - 3 , wherein N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide is injected directly into the tumor. 5. The method of claim 4 , wherein the tumor is a breast cancer tumor, a bladder cancer tumor, a head and neck cancer tumor, a non-small cell lung cancer tumor, a small cell lung cancer tumor, a colorectal cancer tumor, a gastrointestinal stromal tumor, a gastroesophageal carcinoma, a renal cell cancer tumor, a prostate cancer tumor, a liver cancer tumor, a colon cancer tumor, a pancreatic cancer tumor, an ovarian cancer tumor, a lymphoma, or a cutaneous T-cell lymphoma, or a melanoma.
Assignees
Inventors
Classifications
against CD28 or CD152 · CPC title
against tumor tissues, cells, antigens · CPC title
Solutions {(composition of solutions A61K47/00)} · CPC title
Antineoplastic agents · CPC title
comprising antibodies · CPC title
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Frequently asked questions
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- What does patent US10583134B2 cover?
- Methods and therapeutic combinations useful for increasing cell-mediated anti-tumor responses are described. The methods include administering to a subject a therapeutically effective amount of an Immune Response Modifier Compound and a therapeutically effective amount of one or more immune checkpoint inhibitor compounds.
- Who is the assignee on this patent?
- 3M Innovative Properties Co, Univ Texas, Board Of Regents The Univ Of Texas
- What technology area does this patent fall under?
- Primary CPC classification A61K31/4745. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 10 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).