IRAK4 inhibiting agents

Patent metadata

Field	Value
Publication number	US-10577367-B2
Application number	US-201916271497-A
Country	US
Kind code	B2
Filing date	Feb 8, 2019
Priority date	Jul 18, 2014
Publication date	Mar 3, 2020
Grant date	Mar 3, 2020

Abstract

Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.

First claim

What is claimed is:

1. A compound represented by the formula

or a pharmaceutically acceptable salt thereof, wherein:
one of W and X is N, and the other of W and X is C;
R 1 is C 1-6 alkyl optionally substituted with N(R 10 ) 2 ;
R 10 is H or C 1-4 alkyl;
R 2 is H, F or —OR 2a ;
R 2a is H or C 1-4 alkyl;
R 3 is C(O)N(R 3a ) 2 or C 1-4 alkyl, wherein said C 1-4 alkyl is optionally substituted with one to three halo or —OR 3a ; and
R 3a in each occurrence is independently selected from H and C 1-4 alkyl.

2. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

3. A method for treating rheumatoid arthritis or ischemic kidney injury in a subject, comprising administering to the patient a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof, thereby treating rheumatoid arthritis or ischemic kidney injury.

4. The method of claim 3 , wherein the method is for treating rheumatoid arthritis.

5. The compound of claim 1 , wherein the compound is represented by the following structural formula:

or a pharmaceutically acceptable salt thereof.

6. The compound of claim 1 , wherein the compound is represented by the following structural formula:

or a pharmaceutically acceptable salt thereof.

Assignees

• Biogen Ma Inc

Inventors

• Chan Timothy
• Guckian Kevin
• Jenkins Tracy
• Thomas Jermaine
• Vessels Jeffery
• Kumaravel Gnanasambandam
• Meissner Robert
• Lyssikatos Joseph
• Lucas Brian
• Leaf Irina
• Duffield Jeremy

Classifications

• A61P37/00

  Drugs for immunological or allergic disorders · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P19/02

  for joint disorders, e.g. arthritis, arthrosis · CPC title

• A61P13/12

  of the kidneys · CPC title

• C07D413/14

  containing three or more hetero rings · CPC title