Blood purification device and priming method

Patent metadata

Field	Value
Publication number	US-10576197-B2
Application number	US-201615571250-A
Country	US
Kind code	B2
Filing date	May 11, 2016
Priority date	May 12, 2015
Publication date	Mar 3, 2020
Grant date	Mar 3, 2020

Abstract

A blood purification device for purifying blood drawn from a body and then returning the blood into the body, including: a pump provided midway along a fluid path through which blood or a dialysis fluid flows; a valve that is provided midway along the fluid path and closes or opens a part of the fluid path; and a control unit that causes a blood purification process of passing the blood or the dialysis fluid through the fluid path for blood purification, a priming process of driving the pump and the valve to supply a priming fluid to the fluid path before the blood purification processing, and a pressure reduction process of reducing pressure in a gap in the fluid path to a negative pressure state before supply of the priming fluid.

First claim

The invention claimed is:

1. A blood purification device for purifying blood drawn from a body and then returning the blood into the body, the blood purification device comprising:
at least one pump arrangement disposed in a fluid path through which blood or a dialysis fluid flows;
at least one valve disposed in the fluid path and closes or opens a part of the fluid path;
a dialysis fluid supply device supplying dialysis fluid to the fluid path, the fluid path including (i) at least a dialyzer for purifying the blood, (ii) a blood line through which the blood flows, and (iii) a dialysis fluid line through which the dialysis fluid flows; and
a controller connected to the at least one pump arrangement and the at least one valve, the controller being configured to control operation of the at least one pump arrangement and the at least one valve, the controller, the at least one pump arrangement, and the at least one valve being configured to cause the blood purification device to perform:
a pressure reduction process of reducing a pressure in a gap in the fluid path to a negative pressure state by controlling the at least one pump arrangement and the at least one valve,
after performing the pressure reduction process, a priming process of controlling driving of the at least one pump arrangement and the at least one valve to operate to cause a priming fluid to be output from the dialysis fluid supply device such that the dialysis fluid introduced from the dialysis fluid supply device is back-filtered into the dialyzer through the dialysis fluid line, and then flows toward the blood line, and
after performing the pressure reduction process and the priming process, a blood purification process of controlling the at least one pump arrangement and the at least one valve to supply the blood or the dialysis fluid through the fluid path to perform blood purification.

2. The blood purification device according to claim 1 , wherein the fluid path further includes an air trap chamber.

3. The blood purification device according to claim 1 , wherein the dialyzer includes a blood purification membrane and purifies blood with the blood purification membrane.

4. The blood purification device according to claim 1 , wherein the at least one pump arrangement includes a blood pump that feeds the blood to the dialyzer, a feeding pump that feeds the dialysis fluid to the dialyzer, and a discharge pump that discharges the dialysis fluid from the dialyzer, and
the controller is configured to drive the at least one valve to close off the fluid path from outside air, and then perform at least one of three functions: reverse driving of the blood pump, driving of the discharge pump, and reverse driving of the feeding pump to reduce pressure in the gap.

5. The blood purification device according to claim 1 , further comprising a dialysis fluid regeneration column that reproduces the dialysis fluid having passed through the dialyzer and returns the dialysis fluid to the dialyzer to circulate the dialysis fluid.

6. The blood purification device according to claim 1 , wherein the at least one pump arrangement includes a vacuum pump located along the fluid path, the vacuum pump being configured to suction air in the fluid path, and the vacuum pump is configured to not feed the dialysis fluid or the blood into the dialyzer, and
the controller is configured to drive the at least one valve to close off the fluid path from outside air, and then drive the vacuum pump to reduce pressure in the gap.

7. A priming method comprising:
providing at least one pump arrangement disposed in a fluid path through which blood or a dialysis fluid flows, and at least one valve disposed in the fluid path that closes or opens a part of the fluid path;
supplying dialysis fluid to the fluid path by a dialysis fluid supply device, the fluid path including (i) at least a dialyzer for purifying the blood, (ii) a blood line through which the blood flows, and (iii) a dialysis fluid line through which the dialysis fluid flows;
reducing, by a controller connected to and controlling operation of the at least one pump arrangement and the at least one valve, a pressure in a gap in the fluid path to a negative pressure state by controlling the at least one pump arrangement and the at least one valve;
after reducing the pressure in the gap, controlling driving of the at least one pump arrangement and the at least one valve to operate to cause a priming fluid to be output from the dialysis fluid supply device such that the dialysis fluid introduced from the dialysis fluid supply device is back-filtered into the dialyzer through the dialysis fluid line, and then flows toward the blood line; and
after both reducing the pressure in the gap and causing the priming fluid to be output from the dialysis fluid supply device, controlling the at least one pump arrangement and the at least one valve to supply the blood or the dialysis fluid through the fluid path to perform blood purification.

Assignees

• Nikkiso Co Ltd

Inventors

• Fujiwara Masato
• Masuda Yoshimichi
• Nimura Hiroshi
• Jimbo Yoichi

Classifications

• B01D61/30

  Accessories; Auxiliary operation · CPC title

• A61M1/36

  Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation {; Extra-corporeal blood circuits} · CPC title

• A61M1/3649 Primary

  using dialysate as priming or rinsing liquid · CPC title

• A61M2205/3331

  Pressure; Flow · CPC title

• A61M2205/3337

  Controlling, regulating pressure or flow by means of a valve by-passing a pump · CPC title