System and method for mass spectrometry imaging
US-2024389905-A1 · Nov 28, 2024 · US
US10575903B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10575903-B2 |
| Application number | US-201715408167-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 17, 2017 |
| Priority date | Jul 16, 2014 |
| Publication date | Mar 3, 2020 |
| Grant date | Mar 3, 2020 |
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A treatment device is disclosed for treatment of a living body lumen. The treatment device can include an optical fiber having an emitting part that emits laser light from a side circumferential surface. Two or more grooves are provided in the emitting part at places different in a longitudinal direction of the emitting part. The two or more grooves have two or more kinds of shapes and intensities of the laser light emitted from the grooves adjacent to each other are different. A maximum region of intensity of the laser light emitted from the emitting part is located on one end side relative to a center position in the longitudinal direction of the emitting part. The intensity of the laser light emitted from the emitting part on the other end side of the emitting part relative to a position of the maximum region decreases toward the other end side.
Opening claim text (preview).
What is claimed is: 1. An optical fiber for treatment of a living body lumen, the optical fiber comprising: an emitting part configured to emit laser light from a side circumferential surface; and two or more annular grooves, the two or more annular grooves being provided in the emitting part at places different in a longitudinal direction of the emitting part, each of the two or more annular grooves having groove forming surfaces having an angle with respect to an axial direction of the optical fiber, and wherein each of the groove forming surfaces in a groove depth direction has at least two surfaces, and wherein the at least two surfaces being different from each other in the angle with respect to the axial direction of the optical fiber. 2. The optical fiber according to claim 1 , wherein the two or more annular grooves extend in a circumferential direction of the optical fiber. 3. The optical fiber according to claim 1 , wherein a groove surface closer to a center axis line of the optical fiber in the at least two surfaces is smaller than a groove surface farther from the center axis line in the angle with respect to the axial direction of the optical fiber. 4. The optical fiber according to claim 3 , wherein a ratio of groove depth of the groove surface closer to the center axis line of the optical fiber in the at least two surfaces to groove depth of the groove surface farther from the center axis line decreases from a proximal side of the optical fiber toward a distal side. 5. The optical fiber according to claim 1 , wherein the optical fiber includes a core, and a cladding covering the core, and wherein cladding has a lower refractive index than the core, and wherein the core forms a higher refractive index region and the cladding forms a lower refractive index region; and a blocking member on a distal end of the core of the optical fiber. 6. The optical fiber according to claim 1 , wherein a width of each of the two or more annular grooves along the axial direction decreases towards a distal end of the optical fiber. 7. A treatment device for treatment of a living body lumen, comprising: a laser light source configured to output a laser light; and an optical fiber having an emitting part configured to emit the laser light from a side circumferential surface, the optical fiber comprising: two or more annular grooves, the two or more annular grooves being provided in the emitting part at places different in a longitudinal direction of the emitting part, each of the two or more annular grooves having groove forming surfaces having an angle with respect to an axial direction of the optical fiber, and wherein each of the groove forming surfaces in a groove depth direction has at least two surfaces, and wherein the at least two surfaces being different from each other in the angle with respect to the axial direction of the optical fiber; a maximum region of intensity of the laser light emitted from the emitting part is located on a first end side relative to a center position in the longitudinal direction of the emitting part; and an intensity of the laser light emitted from the emitting part on a second end side of the emitting part relative to a position of the maximum region decreases toward the second end side. 8. The treatment device according to claim 7 , wherein a groove surface closer to a center axis line of the optical fiber in the at least two surfaces is larger than a groove surface farther from the center axis line in the angle with respect to the axial direction of the optical fiber. 9. The treatment device according to claim 8 , wherein a ratio of groove depth of the groove surface closer to the center axis line of the optical fiber in the at least two surfaces to groove depth of the groove surface farther from the center axis line decreases from a proximal side of the optical fiber toward a distal side. 10. The treatment device according to claim 7 , wherein the optical fiber includes a core, and a cladding covering the core. 11. The treatment device according to claim 10 , wherein cladding has a lower refractive index than the core, and wherein the core forms a higher refractive index region and the cladding forms a lower refractive index region. 12. The treatment device according to claim 11 , comprising: a blocking member on a distal end of the core of the optical fiber. 13. The treatment device according to claim 7 , wherein the two or more annular grooves extend in a circumferential direction of the optical fiber. 14. The treatment device according to claim 7 , wherein a width of each of the two or more annular grooves along the axial direction decreases towards a distal end of the optical fiber. 15. A living body lumen treatment method comprising: inserting an elongated-shaped treatment device having a laser light source configured to output a laser light and an optical fiber an emitting part configured to emit laser light from a side circumferential surface into a living body lumen, the elongated-shaped treatment device including an emitting part configured to emit the laser light from a side circumferential surface, and two or more annular grooves, the two or more annular grooves being provided in the emitting part at places different in a longitudinal direction of the emitting part, each of the two or more annular grooves having groove forming surfaces having an angle with respect to an axial direction of the optical fiber, and wherein each of the groove forming surfaces in a groove depth direction has at least two surfaces, and wherein the at least two surfaces being different from each other in the angle with respect to the axial direction of the optical fiber; and irradiating a wall of the living body lumen with the laser light while the treatment device is moved in a longitudinal direction in the living body lumen, wherein in the irradiating, irradiation with the laser light is carried out in such a manner that a temperature rise rate at each position on the wall of the living body lumen irradiated with the laser light decreases along with elapse of a procedure time. 16. The method according to claim 15 , wherein the elongated-shaped treatment device comprises: different intensities of the laser light being emitted from the two or more annular grooves adjacent to each other. 17. The method according to claim 15 , wherein the elongated-shaped treatment device comprises: a maximum region of intensity of the laser light emitted from the emitting part is located on a first end side relative to a center position in the longitudinal direction of the emitting part; and an intensity of the laser light emitted from the emitting part on a second end side of the emitting part relative to a position of the maximum region decreases toward the second end side. 18. A living body lumen treatment method comprising: inserting an elongated-shaped treatment device having a laser light source configured to output a laser light and an optical fiber having an emitting part configured to emit laser light from a side circumferential surface into a living body lumen, the elongated-shaped treatment device including an emitting part configured to emit the laser light from a side circumferential surface, and two or more annular grooves, the two or more annular grooves being provided in the emitting part at places different in a longitudinal direction of the emitting part, each of the two or more annular grooves having groove forming surfaces having an angle with respect to an axial direction of the optical fiber, and wherein each of the groove f
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