Device and method for disruption detection

Patent metadata

Field	Value
Publication number	US-10569005-B2
Application number	US-201615569222-A
Country	US
Kind code	B2
Filing date	Jun 3, 2016
Priority date	Jun 25, 2015
Publication date	Feb 25, 2020
Grant date	Feb 25, 2020

Abstract

A monitoring device detects a disruption of a fluid connection between first and second fluid containing systems using one or more pressure sensors arranged in the first fluid containing system to detect first pulses from the first fluid containing system and second pulses from the second fluid containing system. The monitoring device receives (501) pressure signal(s) from the pressure sensor(s), populates (504) signal vectors by signal segments in the pressure signal(s) and computes (505) one or more eigenvectors and/or one or more eigenvalues for the signal vectors by a source separation algorithm. The monitoring device detects (506) the disruption based on a monitoring parameter, which is computed as a function of the eigenvector(s) and/or eigenvalue(s) to be responsive to the second pulses in the pressure signal(s). The monitoring device may be associated with or included in an apparatus for extracorporeal blood processing, such as a dialysis machine.

First claim

The invention claimed is:

1. A monitoring device for detecting a disruption of a fluid connection between a first fluid containing system comprising a first pulse generator and a second fluid containing system comprising a second pulse generator, said monitoring device comprising:
an input for receiving at least one pressure signal from a set of pressure sensors arranged in the first fluid containing system to detect first pulses originating from the first pulse generator and second pulses originating from the second pulse generator; and
a signal processor connected to the input and being configured to:
populate a plurality of signal vectors of identical length such that each of the signal vectors corresponds to a respective signal segment of signal values in the at least one pressure signal;
process the signal vectors by a source separation algorithm so as to compute one or more eigenvector and/or one or more eigenvalue associated with the signal vectors; and
detect the disruption based on a monitoring parameter, which is computed as a function of the one or more eigenvector and/or the one or more eigenvalue to be responsive to the second pulses in the at least one pressure signal.

2. The monitoring device of claim 1 , wherein the signal processor is configured, when processing the signal vectors by the source separation algorithm, to compute the one or more eigenvector and/or the one or more eigenvalue for an estimated covariance matrix comprising estimated covariance values for the signal vectors.

3. The monitoring device of claim 2 , wherein the estimated covariance matrix is given by ƒ(X T X), wherein X is a matrix with the signal vectors arranged as rows or columns, X T is a transpose of the matrix X, and ƒ is a linear function.

4. The monitoring device of claim 2 , wherein the signal processor is further configured, when processing the signal vectors, to:
compute the estimated covariance values,
populate the estimated covariance matrix by the estimated covariance values, and
process the estimated covariance matrix for computation of the one or more eigenvector and/or the one or more eigenvalue.

5. The monitoring device of claim 1 , wherein the source separation algorithm comprises one of Principal Component Analysis, PCA, and Independent Component Analysis, ICA.

6. The monitoring device of claim 1 , wherein the signal processor is configured to populate the signal vectors such that at least a subset of the signal vectors corresponds to mutually time-shifted signal segments in a dedicated pressure signal included among the at least one pressure signal, or in an intermediate signal generated based on the at least one pressure signal.

7. The monitoring device of claim 6 , wherein the signal processor is configured to populate the signal vectors such that said at least a subset of the signal vectors corresponds to partly overlapping and mutually time-shifted signal segments in the dedicated pressure signal or the intermediate signal.

8. The monitoring device of claim 6 , wherein the signal processor is configured to populate the signal vectors exclusively based on the mutually timeshifted signal segments in the dedicated pressure signal or the intermediate signal.

9. The monitoring device of claim 1 , wherein the at least one pressure signal comprises a plurality of pressure signals from a plurality of pressure sensors, and wherein the signal processor is configured to populate the signal vectors such that each signal vector corresponds to a respective signal segment from a respective one of the plurality of pressure signals.

10. The monitoring device of claim 1 , wherein the signal processor is further configured, when detecting the disruption, to identify a change to the monitoring parameter over time or compare the monitoring parameter to a threshold value.

11. The monitoring device of claim 1 , wherein the signal processor is configured, when processing the signal vectors, to compute a plurality of eigenvalues, and
wherein the signal processor is further configured to compute the monitoring parameter to represent one of:
a magnitude of at least a subset of the plurality of eigenvalues,
a difference between pairs of eigenvalues for at least a subset of the plurality of eigenvalues when ordered by magnitude, and
a distribution of at least a subset of the plurality of eigenvalues when ordered by magnitude.

12. The monitoring device of claim 1 , wherein the signal processor is configured, when processing the signal vectors, to compute a plurality of eigenvalues and/or a plurality of eigenvectors, and wherein the signal processor is further configured, when computing the monitoring parameter, to order the eigenvectors and/or the eigenvalues by order of magnitude of the eigenvalues.

13. The monitoring device of claim 12 , wherein the signal processor is configured to compute the monitoring parameter based on at least one selected eigenvector among the plurality of eigenvectors and/or at least one selected eigenvalue among the plurality of eigenvalues, and wherein the signal processor is configured to derive each selected eigenvalue by selecting an eigenvalue having a predefined order number among the plurality of eigenvalues when ordered by magnitude, and/or to derive each selected eigenvector by selecting an eigenvector having a predefined order number among the plurality of eigenvectors when ordered by magnitude of their associated eigenvalues.

14. The monitoring device of claim 13 , wherein the signal processor is configured to compute the monitoring parameter to represent a magnitude of the at least one selected eigenvalue.

15. The monitoring device of claim 13 , wherein the signal processor is configured to compute the monitoring parameter to represent one of:
a frequency of the at least one selected eigenvector, and
a shape of the at least one selected eigenvector.

16. The monitoring device of claim 1 , wherein the signal processor is configured to receive, via the input, a reference pressure signal from a reference pressure sensor in the set of pressure sensors in the first fluid containing system, the reference pressure sensor being arranged to detect the second pulses irrespective of the disruption of the fluid connection,
wherein the signal processor is further configured to:
populate a plurality of reference signal vectors of identical length such that each of the reference signal vectors corresponds to a respective signal segment of signal values in the reference pressure signal, and
process the reference signal vectors by the source separation algorithm so as to compute at least one of: one or more reference eigenvector and one or more reference eigenvalue associated with the reference signal vectors,
wherein the signal processor is configured, when detecting the disruption, to compare the one or more eigenvector to the one or more reference eigenvector and/or compare the one or more eigenvalue to the one or more reference eigenvalue.

17. The monitoring device of claim 16 , wherein the signal processor is configured to compute the monitoring parameter as a function of a correlation value resulting from a cross-correlation of at least one selected eigenvector and the one or more reference eigenvector.

18. The monitoring device of claim 1 , wherein the signal processor is further configured, before populating the plurality of signal vectors to filter the at least one pressure signal so as to decrease a magnitude of the first pulses below a magnitude of the second pulses.

19. The monitoring device of claim 1 ,

Assignees

• Gambro Lundia Ab

Inventors

• Solem Kristian
• Olde Bo

Classifications

• A61B5/0215

  by means inserted into the body · CPC title

• A61B5/02152

  specially adapted for venous pressure · CPC title

• A61M2205/18

  with alarm · CPC title

• A61M2205/3331

  Pressure; Flow · CPC title

• A61M2230/30

  Blood pressure (A61M2230/04 takes precedence) · CPC title