Methods for preventing or mitigating acute allergic responses using human milk oligosaccharides

Patent metadata

Field	Value
Publication number	US-10568896-B2
Application number	US-201415037743-A
Country	US
Kind code	B2
Filing date	Nov 18, 2014
Priority date	Nov 19, 2013
Publication date	Feb 25, 2020
Grant date	Feb 25, 2020

Abstract

A method for preventing or mitigating an acute allergic response in a subject is disclosed. The method includes a step of administering a nutritional composition to the subject. The nutritional composition includes at least one of an acidic or a neutral HMO, but does not include an N-acetyl-lactosamine.

First claim

We claim:

1. A method for mitigating an acute allergic response in a subject in need thereof, the method comprising administering a nutritional composition to the subject, wherein the nutritional composition comprises at least one human milk oligosaccharide (HMO) selected from the group consisting of 2′-fucosyllactose (2′-FL), 6′-sialyllactose (6′-SL), and combinations thereof, wherein the nutritional composition does not contain an N-acetyl-lactosamine; and wherein the nutritional composition comprises lactose in an amount of 0% to 55% relative to total carbohydrate in the nutritional composition.

2. The method of claim 1 , wherein the acute allergic response comprises one or more mast cell mediated immediate allergic response.

3. The method of claim 2 , wherein the one or more mast cell mediated immediate allergic response is selected from the group consisting of a skin mast cell response, a gastrointestinal mast cell response, and a respiratory mast cell response.

4. The method of claim 2 , wherein the nutritional composition comprises either 2′-FL or 6′-SL, but not both.

5. The method of claim 2 , wherein a nutritional composition comprising either 2′-FL or 6′-SL, or both, is administered to the subject to mitigate an acute allergic response comprising more than one mast cell mediated immediate allergic response.

6. The method of claim 4 , wherein a nutritional composition comprising 2′-FL is administered to the subject to mitigate one mast cell mediated immediate allergic response.

7. The method of claim 4 , wherein a nutritional composition comprising either 2′-FL or 6′-SL is administered to the subject to mitigate a skin mast cell response.

8. The method of claim 4 , wherein a nutritional composition comprising 2′-FL is administered to the subject to mitigate a gastrointestinal mast cell response.

9. The method of claim 5 , wherein a nutritional composition comprising both 2′-FL and 6′-SL is administered to the subject to mitigate an acute allergic response comprising more than one mast cell mediated immediate allergic response.

10. The method of claim 1 , wherein the nutritional composition further comprises at least one of a protein source, a carbohydrate source, and a fat source.

11. The method of claim 1 , wherein the nutritional composition is administered orally.

12. The method of claim 1 , wherein the nutritional composition is administered topically.

13. The method of claim 1 , further comprising administering an antihistamine to the subject.

14. The method of claim 13 , wherein the antihistamine comprises a compound selected from the group consisting of loratadine, fexofenadine, and cetirizine.

15. The method of claim 1 , further comprising administering an eicosanoid inhibitor to the subject.

16. The method of claim 15 , wherein the eicosanoid inhibitor comprises a compound selected from the group consisting of inhibitors of thromboxanes, prostaglandins, and leukotrienes.

17. The method of claim 1 , wherein the nutritional composition further comprises a carbohydrate selected from the group consisting of maltodextrin, com syrup solids, and sucrose.

18. The method of claim 1 , wherein the nutritional composition further comprises a hypoallergenic form of galacto-oligosaccharide.

Assignees

• Abbott Lab

Inventors

• Buck Rachael
• Davis Steven
• Forsythe Paul

Classifications

• A23V2250/00

  Food ingredients · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A23V2200/00

  Function of food ingredients · CPC title

• A23L29/04

  Fatty acids or derivatives · CPC title

• A23L21/00

  Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof · CPC title