Temozolomide compounds, polymers prepared therefrom, and method of treating a disease

Patent metadata

Field	Value
Publication number	US-10562901-B2
Application number	US-201715709862-A
Country	US
Kind code	B2
Filing date	Sep 20, 2017
Priority date	Sep 22, 2016
Publication date	Feb 18, 2020
Grant date	Feb 18, 2020

Abstract

A temozolomide compound according to formula (I)

is described, wherein R 1 , L 1 , and X are defined herein. The temozolomide compound can be used to prepare polymers comprising temozolomide. Additionally, the polymers comprising temozolomide can be particularly useful in the treatment of certain diseases.

First claim

The invention claimed is:

1. A temozolomide compound of structure (I)

wherein
X is —O— or —NH—;
n is 1;
L 1 is a divalent C 1-6 alkylene group; and
R 1 is a methacrylate group, a methacrylamide group, an acrylate group, or an acrylamide group.

2. A temozolomide compound of structure (I)

wherein
X is —O— or —NH—;
n is 1;
L 1 is a divalent di(C 2-6 alkylene) disulfide group; and
R 1 is a methacrylate group.

3. A temozolomide compound of structure (I)

wherein
X is —O— or —NH—;
n is 1;
L 1 is a divalent C 1-6 alkylene group; and
R 1 is a methacrylamide group.

Assignees

• Univ Massachusetts

Inventors

• Emrick Todd
• Skinner Matthew
• Ward Sarah M
• Saha Banishree

Classifications

• C08G65/3317

  phenolic · CPC title

• C08F22/10

  Esters · CPC title

• A61K47/545

  Heterocyclic compounds (A61K47/558 takes precedence) · CPC title

• C08G65/32

  Polymers modified by chemical after-treatment · CPC title

• A61K47/58

  obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin · CPC title