Methods of treating RSV infections

Patent metadata

Field	Value
Publication number	US-10561805-B2
Application number	US-201515517693-A
Country	US
Kind code	B2
Filing date	Oct 9, 2015
Priority date	Oct 10, 2014
Publication date	Feb 18, 2020
Grant date	Feb 18, 2020

Abstract

Methods are provided for the treatment of RSV infections in young children. More specifically, methods are provided wherein polypeptides that bind F protein of hRSV and that neutralize RSV infection are administered to the lungs of young children at specific dose regimens.

First claim

The invention claimed is:

1. A method for treating a respiratory syncytial virus (RSV) infection in a young child, the method comprising the following step:
administering to a subject a polypeptide that binds a protein of human RSV (hRSV), wherein the protein is glycoprotein F (F-protein), wherein the polypeptide has the amino acid sequence of SEQ ID NO: 71, wherein the polypeptide is administered by inhalation with a vibrating mesh nebulizer at a deposited dose of 0.020-0.040 mg/kg daily and wherein the subject is a young child.

2. The method of claim 1 , wherein the polypeptide is administered at an inhaled dose of 0.20-0.40 mg/kg daily.

3. The method of claim 1 , wherein the polypeptide is administered at a nominal dose of 1.00-2.00 mg/kg daily.

4. The method of claim 1 , wherein the step of administering is performed daily for 2 to 5 consecutive days.

5. The method of claim 1 , wherein the step of administering is performed daily for 3 consecutive days.

6. The method of claim 1 , wherein the young child is less than 2 years old.

7. The method of claim 1 , wherein the step of administering is performed by use of a nebulizer.

8. The method of claim 1 , wherein the polypeptide is the only therapeutic agent administered to the young child.

9. The method of claim 1 , further comprising the step of administering to the young child an additional therapeutic agent.

10. The method of claim 9 , wherein the additional therapeutic agent is a bronchodilator.

Assignees

• Ablynx Nv
• Vectura Gmbh

Inventors

• Allosery Koen
• Depla Erik
• Huber Martin
• Kolb Tobias
• Müllinger Bernhard
• Germani Massimiliano
• Schick Juliane
• Sargentini Maria-Laura

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P31/14

  for RNA viruses · CPC title

• A61P11/00

  Drugs for disorders of the respiratory system · CPC title

• A61M15/0013

  with inhalation check valves · CPC title

• A61M16/205

  used for exhalation control · CPC title